Protein Alignment TBC1D16 and SGSM1

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001035037.1
• Gene: SGSM1 / 129049
• HGNCID: 29410
• Length: 1148
• Species: Homo sapiens
• Alignment Length: 977
• Identity: 183/977 - (18%)
• Similarity: 304/977 - (31%)
• Gaps: 438/977 - (44%)

  Fly    33 ILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLN 97
            :|:.||||.:.|    ||:.:.:  ||||:......|          :.|.|.||..:    |.:
Human   256 LLYGKNNVLVQP----RDDMEAV--PGYLSLHQTADV----------MTLKWTPNQLM----NGS 300

  Fly    98 ADD-------------------------------------------------------------C 101
            ..|                                                             |
Human   301 VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSC 365

  Fly   102 -------RGQCNP---------------RSKSPDSRNGYCHVTIPQTIQERDIREEDENAAD--- 141
                   .||.:|               |.:||..       :...|..::|    |:.|.|
Human   366 LENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQG-------SAESTSSDKD----DDEATDYVF 419

  Fly   142 ------MQELKNELQPLLGGQAASID------------DLTALLKNN------------------ 170
                  ||  ...:.|...|..:|:.            .:..:.:.:
Human   420 RIIYPGMQ--SEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPKE 482

  Fly   171 ----PITSVNITISN-PQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPAT---------- 220
                |...:::::|| |.:...:           |..::||.|:. ||..||.:|
Human   483 QPPMPQDLMDVSVSNLPSLWQPS-----------PRKSSCSSCSQ-SGSADGSSTNGCNHERAPL 535

  Fly   221 ----DNPKWTTPELL--AFKHNLEFPDSGNSTPADRQKSAMKCRHFS---VDLSQMRSLRLFFND 276
                ||.|:   ::|  ||...|.:                 |||.|   ..||.:.:..:...|
Human   536 KLLCDNMKY---QILSRAFYGWLAY-----------------CRHLSTVRTHLSALVNHMIVSPD 580

  Fly   277 DNCTSGQLVIASRESQYKILH-------------FHYGG-------------LDH---------- 305
            ..|.:||.:.|....||  ||             .:|||             |.|
Human   581 LPCDAGQGLTARIWEQY--LHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETER 643

  Fly   306 ----------LAQVLHQW--------------------------------HCFLH---NITSETG 325
                      .||.:.:|                                |..||   .|::|:.
Human   644 KEVDEQIHACYAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESS 708

  Fly   326 QDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKGQIED--------DLLLRK 382
            |.           |....:...:|.|.....::..:......:..:|::|:        :|:...
Human   709 QS-----------CSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGT 762

  Fly   383 CV----------FFGGL----EKSL----------RKTVWPFLL---------KCYSFSSTFEDR 414
            |.          |..||    |.||          |.|  |.:|         :..|.::|.:|.
Human   763 CSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNT--PTVLRPRDGSVDDRQSSEATTSQDE 825

  Fly   415 A--------------VLMDIKRQEYEEIT------------------------------RKRLYS 435
            |              :|.:....|:..||                              .:...|
Human   826 APREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLS 890

  Fly   436 MSPEQQIHFWKTVQIVV--------------------------------EKDVVRTDRTNPFFCG 468
            ..||.:..|.....:.|                                ||||.|.||...:|
Human   891 EEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYF-- 953

  Fly   469 DDNP-NTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVC 529
              .| |.|.::||:.::...:..:.|.|||.|||||:|..:.:|:..|.||..||:|.   |
Human   954 --TPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNF--- 1013

  Fly   530 TPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEAC 594
             |....:|.:.:.:|.||:|:....::.:.|:.|.....||:||.||.||||.....|..:||..
Human  1014 -PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETI 1077

  Fly   595 WS--NYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYR 657
            |:  :..:.::.||:.||::.||.|.::..|:...:::..|:.:|...:.:.:|:.||.|:::.:
Human  1078 WAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1142

  Fly   658 QL 659
            .|
Human  1143 TL 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	81/335 (24%)
SGSM1	NP_001035037.1	RUN	44..188	CDD:280855
		PH_RUTBC	254..425	CDD:275431	31/199 (16%)
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250|UniProtKB:Q8BPQ7	256..297		17/56 (30%)
		Required for interaction with RAP family members	301..350		1/48 (2%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..411		6/44 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..830		24/142 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..894		1/22 (5%)
		TBC	<936..1105	CDD:214540	60/176 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810