Protein Alignment TBC1D16 and tbc1d2b

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_002666912.2
• Gene: tbc1d2b / 100330777
• ZFINID: ZDB-GENE-100922-148
• Length: 946
• Species: Danio rerio
• Alignment Length: 706
• Identity: 124/706 - (17%)
• Similarity: 235/706 - (33%)
• Gaps: 200/706 - (28%)

  Fly     4 GSIIKKASSFILGDERLDRKIDIAY----EDNEILFCKNNVCIHPPTIARDESDILHNPGYLTCT 64
            ||.|:.:.|.:......:.:..:.|    ||.|:        :.|||         .:|....|.
Zfish   213 GSEIRNSMSHLRPGRAGENRRSVFYTGGSEDWEM--------VDPPT---------KDPAPSDCQ 260

  Fly    65 TKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQE 129
            .:.....:|.:...:.......|.|..|....:     |...|...:..|...|....|.: :|.
Zfish   261 HRESSSHFNRSSIGSAFTFDFRNPSKIKRPFHS-----GSGKPNHSAESSPVEYNETKISK-LQL 319

  Fly   130 RDIREEDENAADMQELKNELQPLLGGQ------------------AASIDDLTALLKNNPI---- 172
            | |:.:.|..:.:||.:|:|:..||.|                  .:::......|:.|.:
Zfish   320 R-IQSQQEEISQLQEQENKLREELGSQKELVRLLQKTLRSAQCDWPSTVGPHNHYLEENEVDKAL 383

  Fly   173 ----TSVNITISNPQ---IENSNISQSFNCI----------------TIRPDSNNCSDCTNGSGV 214
                |.:....|:.:   :|..::.|....:                ||:.........:..||.
Zfish   384 TERDTQIKDLCSHMEKLALEKESLQQELKGLKIKVGEINEQLGMLMETIQAKDEVIMKLSQPSGE 448

  Fly   215 GDGPATDNPKWTTP-------ELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRL 272
            |:   |.:.:..:|       ||...|.:|:...|.|             :..:.::.::..||
Zfish   449 GE---TQSAECNSPSVTREQQELNTLKDSLQGYKSQN-------------KFLNKEIIELTVLR- 496

  Fly   273 FFNDDNCTSGQLVIASRESQYKILHFHYGGLD-HLAQVLHQWHCFLHNITS-------------- 322
                          .:.||:.|:|...|..|: .|.||..::...|..:.|
Zfish   497 --------------RNAESREKLLEAKYNSLEAKLCQVESKYLVLLQEVKSPVCSSSEQTHSGDV 547

  Fly   323 -----------------------------------------ETGQDKFDLPYRHFMVCRPEVKKS 346
                                                     |..::|.:...|..     ::|..
Zfish   548 ITRLLEDALQVESTDQQEHPVLKPNAVSEYDIYGFKTVPEEEDEEEKLEAKKRAL-----DLKSL 607

  Fly   347 EMHPDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTF 411
            .:...|..|:....|:...|:..|..:..|    .|.:..||:....|..||.:   |.||..
Zfish   608 SLTDQETSVRVKWDNYLAITMNREMVRSPD----LKALMRGGVPHIHRSKVWSW---CVSFHV-- 663

  Fly   412 EDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEV 476
               ..:.|.:.::|..    .|..|:.::.....|.:::    |::||...|..:...|:...:.
Zfish   664 ---KKMRDCQPKDYYH----NLLCMANDKPNPACKQIEL----DLLRTLPNNKHYSSPDSDGIQK 717

  Fly   477 MKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGL----MQRAFFVCTPTDRDVD 537
            ::|:||.|:..|..:.|.||::.|.|..|..:..| :.|||.|.:    |...::..|.....||
Zfish   718 LRNVLLAFSWRNPDIGYCQGLNRLAAIALLYLDQE-DAFWCLVAIVEVFMPHDYYTKTLLGSQVD 781

  Fly   538 HNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEA 593
            ..:  .::|:...||..:.|.|.:.....|: ...|.|:.|.......::.::|::
Zfish   782 QRV--FKDLMYEKLPRLHAHFEHYKVDFSLI-TFNWFLVVFVDSVVSDILFKIWDS 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	48/211 (23%)
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457	19/109 (17%)
		TPR_MLP1_2	313..434	CDD:285204	20/122 (16%)
		USP8_interact	317..>359	CDD:286082	11/42 (26%)
		TBC	643..859	CDD:214540	48/212 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810