DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIB and SUA7

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_015411.1	Gene:	SUA7 / 856201	SGDID:	S000006290	Length:	345	Species:	Saccharomyces cerevisiae

Alignment Length:	315	Identity:	108/315 - (34%)
Similarity:	167/315 - (53%)	Gaps:	16/315 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CYAHPESPLIEDYRAGDMICSECGLVVGDRVIDVGSEWRTFSN-EKSGVDPSRVGGPENPLLSGG 77
            |..:|.. ::|.:..||::|:.||||:.|:::|..|||||||| :.:|.||||||...||||.|.
Yeast    27 CKVYPPK-IVERFSEGDVVCALCGLVLSDKLVDTRSEWRTFSNDDHNGDDPSRVGEASNPLLDGN 90

  Fly    78 DLSTIIGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFK 142
            :|||.||.|..:.........|.|.:..|...|..:.:||.:|:.:.|...|||.:.|.|...:|
Yeast    91 NLSTRIGKGETTDMRFTKELNKAQGKNVMDKKDNEVQAAFAKITMLCDAAELPKIVKDCAKEAYK 155

  Fly   143 QVHDGKNLKGRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKA------- 200
            ..||.|.|||:|.::..:|.:.|.||:..|.||||||.::..:..||.|:...:....
Yeast   156 LCHDEKTLKGKSMESIMAASILIGCRRAEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSED 220

  Fly   201 --LETSVDLITTAD---FMCRFCANLDLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMA 260
              |:...|.::.|.   ::.|||::|.||..|..:|.:.|||..|:..:.|:|||::|..:||:.
Yeast   221 GFLKIDTDNMSGAQNLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYLN 285

  Fly   261 SQASEHKRSQKEIGDIAGVADVTIRQSYKLMYPHAAKLFPEDF--KFTTPIDQLP 313
            ....:...:..::|....|.:.||:..||::|.|..||.....  .....:|.||
Yeast   286 ILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVVSLDNLP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	97/279 (35%)
SUA7	NP_015411.1	SUA7	21..333	CDD:224323	105/306 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344164
Domainoid	1	1.000	56	1.000	Domainoid score	I2697
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1158
Inparanoid	1	1.050	185	1.000	Inparanoid score	I935
Isobase	1	0.950	-	0	Normalized mean entropy	S704
OMA	1	1.010	-	-		QHG62181
OrthoFinder	1	1.000	-	-		FOG0002451
OrthoInspector	1	1.000	-	-		oto99852
orthoMCL	1	0.900	-	-		OOG6_101024
Panther	1	1.100	-	-	LDO	PTHR11618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1497
SonicParanoid	1	1.000	-	-		X2171
TreeFam	1	0.960	-	-
	16	15.740