DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIB and Brf1

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_082469.2	Gene:	Brf1 / 72308	MGIID:	1919558	Length:	676	Species:	Mus musculus

Alignment Length:	272	Identity:	67/272 - (24%)
Similarity:	113/272 - (41%)	Gaps:	36/272 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DYRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRV-------GGPENPLLSGGDLSTI 82
            |...||.:|:.||.|:.|.:|  .||.:...|  ||...|.|       |..:.|.|.||
Mouse    17 DAARGDAVCTGCGSVLEDNII--VSEVQFVEN--SGGGSSAVGQFVSLDGAGKTPTLGGG----- 72

  Fly    83 IGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDG 147
            .....|..|    .|...||.|             :.|..:..::.|.:..:|.|.|.||.....
Mouse    73 FHVNLGKES----RAQTLQNGR-------------RHIHHLGSQLQLNQHCLDTAFNFFKMAVSK 120

  Fly   148 KNLKGRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLITTAD 212
            ...:||......:||||:.||.||.|....::..:.:::...:|:.|.|..:.|..:...|....
Mouse   121 HLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCL 185

  Fly   213 FMCRFCANLDL---PNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMASQASEHKRSQKEIG 274
            ::.||...|:.   .:.|...|..:.::.....:..||.|..:..||:.:|::..:.:|:.||:.
Mouse   186 YIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVI 250

  Fly   275 DIAGVADVTIRQ 286
            .:..|.:.|:|:
Mouse   251 SVVKVCESTLRK 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	67/272 (25%)
Brf1	NP_082469.2	SUA7	4..266	CDD:224323	67/272 (25%)
		Repetitive region	91..172		21/80 (26%)
		Repetitive region	185..269		17/78 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449
		BRF1	449..546	CDD:369495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810