DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIB and Brf2

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_079962.1	Gene:	Brf2 / 66653	MGIID:	1913903	Length:	420	Species:	Mus musculus

Alignment Length:	300	Identity:	63/300 - (21%)
Similarity:	108/300 - (36%)	Gaps:	67/300 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPLIED--YRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSGGDLSTI 82
            |.|:||  |....::||:||.||.:.|:..     |||:|                  |......
Mouse    13 SELVEDSHYSQSQLVCSDCGCVVTEGVLTT-----TFSDE------------------GNFREVT 54

  Fly    83 IGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDG 147
            ....||            :|.:......|.|    :.:..:...:.||.|..|.|.:.:::.:..
Mouse    55 YSRSTG------------ENEQVSRCQQRDL----RRVRDLCRILKLPLTFEDTAISYYQKAYQL 103

  Fly   148 KNLKG---RSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLIT 209
            ..::.   :..:.....|:.|.|||...|.|...||.:...........:...:|.|...|..:.
Mouse   104 SGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGTICTLLYADLDLFSGTYMQMVKLLGLDVPSLC 168

  Fly   210 TADFMCRFCANL---------------DLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYM 259
            .||.:..:|::.               |...|:.|... :.:.|.|..:|.||.|:.:..||.::
Mouse   169 LADLVKSYCSSFKLFQASPSVPAKYVEDKDKMLSRTLL-LVELADETWLVTGRHPLPIITAATFL 232

  Fly   260 ASQA-SEHKRSQKEIGDIAGVADVTIRQSYKLMYPHAAKL 298
            |.|: ....|....:.....:|:|      .|.||.|::|
Mouse   233 AWQSLRPSDRLTCSLAQFCKLANV------DLPYPAASRL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	57/287 (20%)
Brf2	NP_079962.1	SUA7	6..244	CDD:224323	56/270 (21%)
		TF_Zn_Ribbon	6..>37	CDD:285471	11/23 (48%)
		Repetitive region	72..157		15/88 (17%)
		Interaction with target DNA. /evidence=ECO:0000250\|UniProtKB:Q9HAW0	108..114		0/5 (0%)
		Repetitive region	173..249		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..387
		Required for the formation of a ternary complex with DNA and TBP, not required for interaction with TBP in the absence of DNA. /evidence=ECO:0000250\|UniProtKB:Q9HAW0	358..364
		Required for interaction with TBP and formation of a ternary complex with DNA and TBP. /evidence=ECO:0000250\|UniProtKB:Q9HAW0	366..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11618
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910