DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIB and BRF2

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_060780.2	Gene:	BRF2 / 55290	HGNCID:	17298	Length:	419	Species:	Homo sapiens

Alignment Length:	299	Identity:	64/299 - (21%)
Similarity:	111/299 - (37%)	Gaps:	69/299 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LIED--YRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSGGDLSTI-I 83
            |:||  |....::||:||.||.:.|:..     |||:|                   |:|..: .
Human    15 LVEDSHYSQSQLVCSDCGCVVTEGVLTT-----TFSDE-------------------GNLREVTY 55

  Fly    84 GPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDGK 148
            ...||            :|.:...|..|.|    :.:..:...:.||.|..|.|...::|.:...
Human    56 SRSTG------------ENEQVSRSQQRGL----RRVRDLCRVLQLPPTFEDTAVAYYQQAYRHS 104

  Fly   149 NLKG---RSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLITT 210
            .::.   :..:.....|:.|.|||...|.|...||.:...........:...:|.|...|..:..
Human   105 GIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCL 169

  Fly   211 ADFMCRFCANL---------------DLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMA 260
            |:.:..:|::.               |...|:.| ...:.:.|.|..:|.||.|:.|..||.::|
Human   170 AELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSR-TMQLVELANETWLVTGRHPLPVITAATFLA 233

  Fly   261 SQASE-HKRSQKEIGDIAGVADVTIRQSYKLMYPHAAKL 298
            .|:.: ..|....:.....:|:|      .|.||.:::|
Human   234 WQSLQPADRLSCSLARFCKLANV------DLPYPASSRL 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	60/288 (21%)
BRF2	NP_060780.2	SUA7	5..233	CDD:224323	55/258 (21%)
		Repetitive region	72..157		16/88 (18%)
		Interaction with target DNA. /evidence=ECO:0000269\|PubMed:26638071, ECO:0007744\|PDB:4ROC, ECO:0007744\|PDB:4ROD, ECO:0007744\|PDB:4ROE	108..114		0/5 (0%)
		Repetitive region	173..249		16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..351
		Required for the formation of a ternary complex with DNA and TBP, not required for interaction with TBP in the absence of DNA. /evidence=ECO:0000269\|PubMed:26638071	357..363
		Required for interaction with TBP and formation of a ternary complex with DNA and TBP. /evidence=ECO:0000269\|PubMed:26638071	365..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11618
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910