DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIB and brf1a

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_956192.1	Gene:	brf1a / 334402	ZFINID:	ZDB-GENE-030131-6334	Length:	661	Species:	Danio rerio

Alignment Length:	294	Identity:	67/294 - (22%)
Similarity:	130/294 - (44%)	Gaps:	30/294 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DYRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSGGDLSTIIG---PG 86
            |...|..:|..||.|:.|.:|         .:|.:.|:            |||..|:.:|   .|
Zfish    15 DQARGVAVCMGCGSVLEDNII---------VSEVTFVE------------SGGGGSSAVGQFVAG 58

  Fly    87 TGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDGKNLK 151
            ..|.:..:.|. .:|......|...:|.:|.::|:.:..::.:.:..:|.|.|.:|........|
Zfish    59 DASGNVPSLGG-NFQTSVGRESRAATLQNAKRQINHLGHQLQMNQHCLDTAFNFYKMALSKHLTK 122

  Fly   152 GRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLITTADFMCR 216
            ||.:....:||||:.||.||.|....::..:.:::...:|:.|.:..:.|..:...|....::.|
Zfish   123 GRKSTHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLVLARELCINAPAIDPCLYIPR 187

  Fly   217 FCANLDL---PNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMASQASEHKRSQKEIGDIAG 278
            |...|:.   .:.|...|..:.::.....:..||.|..:..||:.:|::..|.:|:.||:..:..
Zfish   188 FAQLLEFGEKSHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHEFRRTIKEVISVVK 252

  Fly   279 VADVTIRQS-YKLMYPHAAKLFPEDFKFTTPIDQ 311
            |.:.|:|:. |:......::|..|:| ..|.::|
Zfish   253 VCEATLRKRLYEFEDTPTSELTIEEF-MKTDLEQ 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	61/270 (23%)
brf1a	NP_956192.1	SUA7	1..277	CDD:224323	63/283 (22%)
		TF_Zn_Ribbon	3..41	CDD:285471	9/34 (26%)
		CYCLIN	83..156	CDD:238003	19/72 (26%)
		CYCLIN	185..258	CDD:294043	16/72 (22%)
		BRF1	439..531	CDD:285040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810