DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIB and ttb-1

DIOPT Version :9

Sequence 1:	NP_001260349.1	Gene:	TfIIB / 34430	FlyBaseID:	FBgn0004915	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_503146.1	Gene:	ttb-1 / 178544	WormBaseID:	WBGene00006648	Length:	306	Species:	Caenorhabditis elegans

Alignment Length:	302	Identity:	188/302 - (62%)
Similarity:	246/302 - (81%)	Gaps:	2/302 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VCCYAHPESPLIEDYRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSG 76
            |.|..||:..||||:||||::|..||||||||::|||:|||:||||:||.||||||.||||||||
Worm     5 VQCPIHPDVHLIEDHRAGDLVCPACGLVVGDRLVDVGTEWRSFSNERSGNDPSRVGAPENPLLSG 69

  Fly    77 GDLSTIIGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLF 141
            |||||.|..|.|.:  |:..:.....|::|:::||.:.:|...|..|::||:||:.|.|.|:.:|
Worm    70 GDLSTTIAVGFGGS--DSDNSLANAQRKSMNNTDRQMTAAMSLIREMSERIHLPRNIQDSASRIF 132

  Fly   142 KQVHDGKNLKGRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVD 206
            |.|.:.|.|:|::|:|:|:||||||||::|||||||||||||::||||||||||:.:::|||:::
Worm   133 KDVLESKALRGKNNEAQAAACLYIACRKDGVPRTFKEICAVSRVSKKEIGRCFKIIVRSLETNLE 197

  Fly   207 LITTADFMCRFCANLDLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMASQASEHKRSQK 271
            .||:||||.|||.||.|||.:|.|||.|||.||:||:|.||:|||:||||||||||||..|||.|
Worm   198 QITSADFMSRFCGNLSLPNSIQAAATRIAKCAVDMDLVAGRTPISIAAAAIYMASQASAEKRSAK 262

  Fly   272 EIGDIAGVADVTIRQSYKLMYPHAAKLFPEDFKFTTPIDQLP 313
            ||||:||.|::|:||:|||:||.|.:|||:||:|.||||.||
Worm   263 EIGDVAGAAEITVRQTYKLLYPKALELFPKDFRFVTPIDALP 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIB	NP_001260349.1	SUA7	22..289	CDD:224323	166/266 (62%)
ttb-1	NP_503146.1	SUA7	6..285	CDD:224323	173/280 (62%)
		TF_Zn_Ribbon	6..45	CDD:285471	24/38 (63%)
		TFIIB	111..181	CDD:278794	42/69 (61%)
		TFIIB	205..275	CDD:278794	49/69 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160052
Domainoid	1	1.000	102	1.000	Domainoid score	I4301
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1158
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1123
Isobase	1	0.950	-	0	Normalized mean entropy	S704
OMA	1	1.010	-	-		QHG62181
OrthoDB	1	1.010	-	-		D381183at33208
OrthoFinder	1	1.000	-	-		FOG0002451
OrthoInspector	1	1.000	-	-		oto17672
orthoMCL	1	0.900	-	-		OOG6_101024
Panther	1	1.100	-	-	LDO	PTHR11618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1497
SonicParanoid	1	1.000	-	-		X2171
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790