Protein Alignment CG5188 and METAP1

DIOPT Version :10

• Sequence 1: NP_609401.2
• Gene: CG5188 / 34428
• FlyBaseID: FBgn0032247
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_055958.2
• Gene: METAP1 / 23173
• HGNCID: 15789
• Length: 386
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 134/327 - (40%)
• Similarity: 186/327 - (56%)
• Gaps: 20/327 - (6%)

  Fly     6 LLNSLMRQKTTARNLFQFGKVKGD--TGKYEQIVSTGQVSPE------RFVPEEIKKPAYYFKNM 62
            ||:...:.:...|.:..: .|:||  |..:.....||::.|.      |.||..|::|.|  .:.
Human    50 LLHKKAKDEKAKREVSSW-TVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDY--ADH 111

  Fly    63 PPGNT------LGSPEIK--SQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILE 119
            |.|.:      .|:.:||  |...|:.|||..|||..:|.....:...|.||::||...|...:.
Human   112 PLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIA 176

  Fly   120 SKAYPSPLRYAGFPKSICTSINNIACHGIPDDRQLADGDIINIDVTVFLNGYHGDCSETFRVGNV 184
            ...|||||.|..||||.|||:|.:.||||||.|.|.:|||:|:|:|::.||||||.:|||.||.|
Human   177 RNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEV 241

  Fly   185 DERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHGIGSYFHGPPEI 249
            |:....||:.|..||.|.|....|||.:.|:|..|.::...:..:.:.::.||||...||..|.:
Human   242 DDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNV 306

  Fly   250 LHY-YNEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGTEIL 313
            .|| .|:..|.|:.|..|||||::..||.:.....|||||::.||.||||||||:|:|:||.|||
Human   307 PHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEIL 371

  Fly   314 TR 315
            ||
Human   372 TR 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5188	NP_609401.2	MetAP1	79..315	CDD:238519	110/236 (47%)
METAP1	NP_055958.2	APP_MetAP	14..382	CDD:469704	134/327 (41%)