Protein Alignment KdelR and erd-2.2

DIOPT Version :10

• Sequence 1: NP_477296.1
• Gene: KdelR / 34427
• FlyBaseID: FBgn0267330
• Length: 212
• Species: Drosophila melanogaster
• Sequence 2: NP_498282.1
• Gene: erd-2.2 / 175833
• WormBaseID: WBGene00016195
• Length: 213
• Species: Caenorhabditis elegans
• Alignment Length: 643
• Identity: 133/643 - (20%)
• Similarity: 212/643 - (32%)
• Gaps: 217/643 - (33%)

  Fly    17 ISFHLVLDRYKIDKVFNFNRNLTEQIDSSLDRIRVNVEKEFQKKNKRKKAKKAPAGQATEDGGAE 81
            |..||..||....:..|.||:|.:||..::.:|...:...|..|.:........|...:.....:
 Worm    43 IFHHLNRDRKASLQRRNHNRSLKQQIMPNVSQISTVLRLAFSCKRRLSNGLHFVARSYSTSDPPK 107

  Fly    82 EPPERLTNMTIADMLAKLTTHPNVQLTVMDADFQIAYNSPEVHAVKLPTSILADFYVSPSRLELH 146
            :|...|||.:......:| .|...|..|:.| |:..:...| |..|.    :.|::|..:.
 Worm   108 QPSGPLTNYSKLVEQGRL-QHDPYQEKVVSA-FENLFGRLE-HFEKQ----MEDYHVRLAE---- 161

  Fly   147 FATPECSAYCWSRGRMPE-------------------SGNAQ-------------QIEWEP-VGS 178
                      |.:.|..|                   |.|.|             |:..|| ||.
 Worm   162 ----------WEKKREEERRKLMVEEAEKKEDDGMWASVNKQGQKLLGRWVLGRRQMNVEPGVGK 216

  Fly   179 ELSYL---------------VQKGDVGLHLKFSCTPMDETGRAGPLTEIISPQPVQAGPGLCPFE 228
            .:|||               |.....||::         .|..|....::......|..|:....
 Worm   217 WVSYLNRERKLDSIVGSRPAVPPAPKGLYI---------YGNVGCGKTMLMDMFYGATDGIIRHR 272

  Fly   229 VRHLFTQQKLR-----------DGQFRVVSYNI---LADLYTDSEYSRTVLFGYTAPYALEIDYR 279
            .|..|.:..|:           :|..:.:.|:|   :.:|..|.:....:        |.|..|:
 Worm   273 QRFHFHEAMLKINEQMHKYWKENGAEKPMQYSISSWIMNLPVDEKVKEWL--------AGEEFYK 329

  Fly   280 KQLFVKEILGYRAD--------------LICLQEVDTKVFSLDLVPIFSRKNLAGHYQAKGKVAE 330
            :||.:|.||...||              ::|..|:.|    :|:..|.:...:.......|.|.
 Worm   330 QQLQMKHILPAVADKFLVDQQSSKKGASILCFDEIQT----VDVFAIVALSGIMSRLLTTGTVL- 389

  Fly   331 GLATFYDLNKF-ELLEKDGVILSEILERYPLLWDRIRDNQPLVERIANRSTALQLTLLRSKHDPR 394
             :||   .|:. ..|.:|| :..||.:::                |:......::..:.|:.|.|
 Worm   390 -VAT---SNRAPRELNQDG-MQKEIFDKF----------------ISKLEKHCEIISIGSEVDYR 433

  Fly   395 KHLLVA------NTHLYFAP--DADHVRLLQMGYAMQYVCEQHER----IRQQY--ELSEATDLA 445
            :   ||      |.| |..|  ||              |.|:.|:    :..||  |::.|| |.
 Worm   434 R---VAAKNSAENVH-YLWPLNDA--------------VLEEFEKMWRQVTDQYGGEITSAT-LP 479

  Fly   446 LVFCGDFNSTPECGIYQLMTQQAVGPDVPDWVSNVDEAVKGVSLSQPFQMGSACGCPEYTNYTVG 510
            ::|                     |..|     .|.|:..||:   .|.....||.|      ||
 Worm   480 VMF---------------------GRTV-----EVPESCSGVA---RFTFEYLCGRP------VG 509

  Fly   511 FKACIDYIFFMRG--ALNVNDVIPMPSEEELSLYQAIPSLV--FPSDHIALVANFEWA 564
               ..|||...:.  .:.::| ||..|.|.....:...:||  ..:.|..||::.|.|
 Worm   510 ---AADYIAVAKNYHTIFISD-IPAMSMEIRDKARRFITLVDELYNHHCCLVSSAETA 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KdelR	NP_477296.1	ER_lumen_recept	28..169	CDD:459945	30/159 (19%)
erd-2.2	NP_498282.1	ER_lumen_recept	28..169	CDD:459945	32/146 (22%)