DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmB and SNRPB

DIOPT Version :9

Sequence 1:	NP_001188780.1	Gene:	SmB / 34426	FlyBaseID:	FBgn0262601	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_937859.1	Gene:	SNRPB / 6628	HGNCID:	11153	Length:	240	Species:	Homo sapiens

Alignment Length:	235	Identity:	137/235 - (58%)
Similarity:	157/235 - (66%)	Gaps:	41/235 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIGKNNKMIQHLNYRVRIVLQDSRTFIGTFKAFDKHMNLILGDCEEFRKIRSKNSKVPEREEKR 65
            ||:||::||:||::||:|.:|||.|.||||||||||||||||.||:|||||:.||||..||||||
Human     1 MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKR 65

  Fly    66 VLGFVLLRGENIVSLTVEGPPPPEEGLPRVPIPGAAPGPGIGRVAGRGMP--INLSAVPAGLQGP 128
            |||.|||||||:||:|||||||.:.|:.|||:.|||.||||||.||||:|  :.:...||||.||
Human    66 VLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGP 130

  Fly   129 VRGVGGPAQQHMAPMGRGV-------------------------PRAPM-MGAPPPGMI---PGG 164
            |||||||:||.|.|.|||.                         |..|| .|||||||:   ||.
Human   131 VRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGM 195

  Fly   165 MPSMPGNMG--------RGAPPP-MRGPPPSMIRGAPPPG 195
            .|.|...||        .|.||| ||.|||.| ||.||||
Human   196 RPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGM-RGPPPPG 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmB	NP_001188780.1	Sm_B	5..82	CDD:212464	57/76 (75%)
SNRPB	NP_937859.1	Sm_B	5..83	CDD:212464	58/77 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..240		32/73 (44%)
		Repeat-rich region	175..236		32/61 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141598
Domainoid	1	1.000	124	1.000	Domainoid score	I5531
eggNOG	1	0.900	-	-		E1_COG1958
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3228
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54849
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002776
OrthoInspector	1	1.000	-	-		otm41722
orthoMCL	1	0.900	-	-		OOG6_101868
Panther	1	1.100	-	-	LDO	PTHR10701
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1254
SonicParanoid	1	1.000	-	-		X2167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790