DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdfy2 and Wdfy2

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_006252239.1	Gene:	Wdfy2 / 305956	RGDID:	1307337	Length:	400	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	205/406 - (50%)
Similarity:	298/406 - (73%)	Gaps:	8/406 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAEIKPAQRTNNDRFNTSKKPELLSKLEGSSDDVNAAILIPGENGVISVSDDKTVRVWLKRDSG 65
            |||||:|...|        :||.||.::|||.:.||.|:::|.|.||||||:|:|||||||||||
  Rat     1 MAAEIQPQPLT--------RKPILLQRVEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSG 57

  Fly    66 QYWPSICQYMPSGCTAIEYVSESRHLYVGQENGTVTQYALSEDCNRLSFLRDYLSHQARVMAVVF 130
            ||||||...|||.|:.:.:..|:|.|.:|.:|||::::.||||.|:::.:::|.:||:||..|:|
  Rat    58 QYWPSIYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMVLF 122

  Fly   131 SKTHKWILSAGKDKQFAYHCTESGKRVGGYNFETPCTALQFDALAKYAFVGDHAGQITMLRCDVQ 195
            ....:|:||.|:|||||:||:|||:|:|||......:.||||..:::.|:|||:||:|:|:.:.:
  Rat   123 VLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVESRHVFIGDHSGQVTILKLEQE 187

  Fly   196 GVQLITTFNGHSAEIRCLKWVEGPQLLFSGACDQSVLVWDVGGKRGTIYELQGHSNKVSALSYAN 260
            ...|:|:|.||:..:..|.|....::||||:.|.||::||:||::||..|||||::||.|||||.
  Rat   188 NCTLLTSFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDKVQALSYAQ 252

  Fly   261 HTQQLISCGEDSVVVFWEMNAMRKEVPGWVDTNNCQLCSRPFFWNFRSMMDQKQLGIRQHHCRHC 325
            ||:||||||.|..:|.|.|:..|:|.|.|:|:::||.|.:||||||:.|.|.|::|:||||||.|
  Rat   253 HTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKC 317

  Fly   326 GKAVCDNCSTNRINIPIMGFEFDVRTCDPCYKQLQTVERPSLASFNDAKHSIVYMDLDEDRKRLL 390
            |||||..||:.|.:||:|||||:||.||.|::.:...||...|:|:|:||:||::..|..|..||
  Rat   318 GKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLL 382

  Fly   391 TVGQDRLIKIWDLSNI 406
            |.|.|::||:||::.:
  Rat   383 TAGTDKVIKLWDMTPV 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	202/400 (51%)
		WD40	24..279	CDD:295369	130/254 (51%)
		WD40 repeat	35..72	CDD:293791	28/36 (78%)
		WD40 repeat	80..117	CDD:293791	12/36 (33%)
		WD40 repeat	125..161	CDD:293791	20/35 (57%)
		WD40 repeat	166..205	CDD:293791	15/38 (39%)
		WD40 repeat	211..248	CDD:293791	17/36 (47%)
		WD40 repeat	253..283	CDD:293791	18/29 (62%)
		FYVE_WDFY1_like	287..356	CDD:277258	42/68 (62%)
		WD40 repeat	324..371	CDD:293791	24/46 (52%)
Wdfy2	XP_006252239.1	WD40	16..272	CDD:295369	129/255 (51%)
		WD40	18..394	CDD:225201	192/375 (51%)
		WD40 repeat	27..64	CDD:293791	23/36 (64%)
		WD40 repeat	72..132	CDD:293791	23/59 (39%)
		WD40 repeat	159..197	CDD:293791	14/37 (38%)
		WD40 repeat	203..240	CDD:293791	16/36 (44%)
		WD40 repeat	245..283	CDD:293791	24/37 (65%)
		FYVE_WDFY1_like	279..348	CDD:277258	40/68 (59%)
		WD40 repeat	321..363	CDD:293791	24/41 (59%)
		WD40	358..394	CDD:197651	14/35 (40%)
		WD40 repeat	369..395	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334881
Domainoid	1	1.000	209	1.000	Domainoid score	I2747
eggNOG	1	0.900	-	-		E2759_KOG1409
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14188
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1488
OMA	1	1.010	-	-		QHG52290
OrthoDB	1	1.010	-	-		D228338at33208
OrthoFinder	1	1.000	-	-		FOG0002613
OrthoInspector	1	1.000	-	-		otm46012
orthoMCL	1	0.900	-	-		OOG6_105115
Panther	1	1.100	-	-	LDO	PTHR46189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2322
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810