Protein Alignment Wdfy2 and GGA3

DIOPT Version :10

• Sequence 1: NP_609400.1
• Gene: Wdfy2 / 34425
• FlyBaseID: FBgn0032246
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_619525.1
• Gene: GGA3 / 23163
• HGNCID: 17079
• Length: 723
• Species: Homo sapiens
• Alignment Length: 120
• Identity: 25/120 - (20%)
• Similarity: 42/120 - (35%)
• Gaps: 44/120 - (36%)

  Fly     7 PAQRTNNDRFNTSKKPELLSKLEGSS--DDVNAAILIPGENGVISVSDDKTVRVWLKRDSGQYWP 69
            |..|..|..|:..:|.:||:||..|.  ||:..|              :|.::..:|.|..:
Human   160 PPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEA--------------NKLIKSMVKEDEAR--- 207

  Fly    70 SICQYMPSGCTAIEYVSESRHLYVGQENGTVTQYALSEDCNRLSFLRDYLSHQAR 124
                        |:.|::..|             .|.|..|.:..|.:.|.|.::
Human   208 ------------IQKVTKRLH-------------TLEEVNNNVRLLSEMLLHYSQ 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_609400.1	WD40	24..279	CDD:475233	20/103 (19%)
		WD40 repeat	35..72	CDD:293791	4/36 (11%)
		WD40 repeat	80..117	CDD:293791	7/36 (19%)
		WD40 repeat	125..161	CDD:293791	25/120 (21%)
		WD40 repeat	166..205	CDD:293791
		WD40 repeat	211..248	CDD:293791
		WD40 repeat	253..283	CDD:293791
		FYVE_WDFY1_like	287..356	CDD:277258
		WD40 repeat	324..371	CDD:293791
GGA3	NP_619525.1	Binds to ARF1 (in long isoform)	1..313		25/120 (21%)
		VHS_GGA3	6..146	CDD:340805
		GGA_N-GAT	169..207	CDD:465702	13/51 (25%)
		GAT_GGA3	213..299	CDD:410587	7/38 (18%)
		Unstructured hinge	299..593
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..384
		DXXLL. /evidence=ECO:0000269|PubMed:12060753	391..395
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..464
		Alpha_adaptinC2	601..715	CDD:197886