DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdfy2 and TOM1L2

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001337261.1	Gene:	TOM1L2 / 146691	HGNCID:	11984	Length:	536	Species:	Homo sapiens

Alignment Length:	151	Identity:	32/151 - (21%)
Similarity:	55/151 - (36%)	Gaps:	53/151 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAEIKPAQRTNND-----------RFNTSKKPELLSKLEGS---------SDDVNAAIL----- 40
            |..|:.|.|..::|           |....:..||:|::...         :||:|...|
Human   241 MLTEMVPGQEDSSDLELLQELNRTCRAMQQRIVELISRVSNEEVTEELLHVNDDLNNVFLRYERF 305

  Fly    41 ---------IPGENGVIS-VSDDKTVRVWLKRDSGQYWPSICQYM------PSGCTAIEYVSESR 89
                     ....|||:: |::|..:      |.|...|::...|      ||..:     |:..
Human   306 ERYRSGRSVQNASNGVLNEVTEDNLI------DLGPGSPAVVSPMVGNTAPPSSLS-----SQLA 359

  Fly    90 HLYVGQENGTVTQYALSEDCN 110
            .|.:|.|:.:.|..:| :.||
Human   360 GLDLGTESVSGTLSSL-QQCN 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	31/148 (21%)
		WD40	24..279	CDD:295369	25/117 (21%)
		WD40 repeat	35..72	CDD:293791	10/51 (20%)
		WD40 repeat	80..117	CDD:293791	8/31 (26%)
		WD40 repeat	125..161	CDD:293791
		WD40 repeat	166..205	CDD:293791
		WD40 repeat	211..248	CDD:293791
		WD40 repeat	253..283	CDD:293791
		FYVE_WDFY1_like	287..356	CDD:277258
		WD40 repeat	324..371	CDD:293791
TOM1L2	NP_001337261.1	VHS_Tom1L2	12..148	CDD:340793
TOM1L2	NP_001337261.1	GAT_TM1L2	218..309	CDD:260096	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930