DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdfy2 and wdfy2

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_002936770.1	Gene:	wdfy2 / 100496386	XenbaseID:	XB-GENE-961327	Length:	400	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	201/406 - (49%)
Similarity:	292/406 - (71%)	Gaps:	8/406 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAEIKPAQRTNNDRFNTSKKPELLSKLEGSSDDVNAAILIPGENGVISVSDDKTVRVWLKRDSG 65
            |||||.|...|        :||.||||:|||.|.||.|:::|.|:|:||||:|:|||||:|||||
Frog     1 MAAEIHPKPLT--------RKPVLLSKVEGSQDVVNMAVIVPKEDGLISVSEDRTVRVWMKRDSG 57

  Fly    66 QYWPSICQYMPSGCTAIEYVSESRHLYVGQENGTVTQYALSEDCNRLSFLRDYLSHQARVMAVVF 130
            |:||||...||:.|..:.:..|:|.|.||.:|||::::.||||.|:::..::|.:||.||..|:|
Frog    58 QFWPSIFHAMPAPCCCMCFNPETRRLTVGLDNGTISEFILSEDYNKMNPGKNYTAHQGRVTMVLF 122

  Fly   131 SKTHKWILSAGKDKQFAYHCTESGKRVGGYNFETPCTALQFDALAKYAFVGDHAGQITMLRCDVQ 195
            ....:|:||.|:||.||:||:|:|:|:|.|......:.||||...::|||||.:||:|:|:.:..
Frog   123 VLEMEWLLSTGQDKLFAWHCSETGERLGNYRTAACASCLQFDVETRHAFVGDQSGQVTILKLEQD 187

  Fly   196 GVQLITTFNGHSAEIRCLKWVEGPQLLFSGACDQSVLVWDVGGKRGTIYELQGHSNKVSALSYAN 260
            ...|||||.||:|.:..|.|....:|||||:.|.|:::||:||::||..|||||::||.::|||:
Frog   188 NCSLITTFKGHTAGVTSLCWDPVQRLLFSGSSDHSIIIWDIGGRKGTALELQGHNDKVQSISYAH 252

  Fly   261 HTQQLISCGEDSVVVFWEMNAMRKEVPGWVDTNNCQLCSRPFFWNFRSMMDQKQLGIRQHHCRHC 325
            ||:|||||..|..:|.|.|:..|:|.|.|:|:::||.|.:||||||:.|.|.|::|:||||||.|
Frog   253 HTRQLISCSADGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDHKKIGLRQHHCRKC 317

  Fly   326 GKAVCDNCSTNRINIPIMGFEFDVRTCDPCYKQLQTVERPSLASFNDAKHSIVYMDLDEDRKRLL 390
            |||||..||:.|..||:|||||:||.||.|::.:...:|...|:|:|:||:|:::..|..|..||
Frog   318 GKAVCGKCSSKRSTIPLMGFEFEVRVCDSCHESITDEQRAPTATFHDSKHNIIHVHYDATRVWLL 382

  Fly   391 TVGQDRLIKIWDLSNI 406
            |.|.|::||:||::.:
Frog   383 TSGSDKVIKLWDMTPV 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	198/400 (50%)
		WD40	24..279	CDD:295369	128/254 (50%)
		WD40 repeat	35..72	CDD:293791	25/36 (69%)
		WD40 repeat	80..117	CDD:293791	13/36 (36%)
		WD40 repeat	125..161	CDD:293791	17/35 (49%)
		WD40 repeat	166..205	CDD:293791	18/38 (47%)
		WD40 repeat	211..248	CDD:293791	17/36 (47%)
		WD40 repeat	253..283	CDD:293791	15/29 (52%)
		FYVE_WDFY1_like	287..356	CDD:277258	42/68 (62%)
		WD40 repeat	324..371	CDD:293791	23/46 (50%)
wdfy2	XP_002936770.1	WD40	16..272	CDD:392136	128/255 (50%)
		WD40 repeat	70..112	CDD:293791	15/41 (37%)
		WD40 repeat	117..153	CDD:293791	17/35 (49%)
		WD40 repeat	202..239	CDD:293791	16/36 (44%)
		FYVE_WDFY1_like	279..348	CDD:277258	42/68 (62%)
		WD40 repeat	321..363	CDD:293791	19/41 (46%)
		WD40 repeat	369..395	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14188
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1583
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D228338at33208
OrthoFinder	1	1.000	-	-		FOG0002613
OrthoInspector	1	1.000	-	-		otm49099
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2899
SonicParanoid	1	1.000	-	-		X2322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090