DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RfC3 and RFC4

DIOPT Version :9

Sequence 1:	NP_609399.1	Gene:	RfC3 / 34423	FlyBaseID:	FBgn0032244	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_002907.1	Gene:	RFC4 / 5984	HGNCID:	9972	Length:	363	Species:	Homo sapiens

Alignment Length:	319	Identity:	131/319 - (41%)
Similarity:	191/319 - (59%)	Gaps:	13/319 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MPWVEKYRPSGLDDLISHEEIISTITRFISRKQLPHLLFYGPPGTGKTSTILACARQLYSPQQFK 75
            :||||||||..:|::...||:::.:.:.:....||:|||||||||||||||||.||:|:.|:.|:
Human    38 VPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFR 102

  Fly    76 SMVLELNASDDRGIGIVRGQILNFASTRTIF--------CDTFKLIILDEADAMTNDAQNALRRI 132
            ..||||||||:|||.:||.::.|||.. |:.        |..||::||||||:||:.||.||||.
Human   103 LRVLELNASDERGIQVVREKVKNFAQL-TVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRT 166

  Fly   133 IEKYTDNVRFCVICNYLSKIIPALQSRCTRFRFAPLSQDQMMPRLEKIIEAEAVQITEDGKRALL 197
            :||.:...|||:||||:|:||..|.|||::|||.|||......||..|.:.|.|:|:::|...|:
Human   167 MEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLV 231

  Fly   198 TLAKGDMRKVLNVLQST--VMAFDTVNEDNVYMCVGYPLRQDIEQILKALLSGSSLEDSFKTVES 260
            .:::||:||.:..|||.  :.....:.|..:....|....:.|:.:..|..|||.  |..:.|..
Human   232 KVSEGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGSF--DKLEAVVK 294

  Fly   261 AKYARGLALEDIITELHLFVMRLELPMSVMNKLIVKLAQIEERLAKGCTEVAQTAALVA 319
            .....|.|...::.:||..|:...|.....:.:..|||::::.||.|..|..|..:|.|
Human   295 DLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCA 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RfC3	NP_609399.1	rfc	12..321	CDD:234763	131/318 (41%)
RFC4	NP_002907.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
RFC4	NP_002907.1	Rad17	39..353	CDD:330523	130/316 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53599
OrthoDB	1	1.010	-	-		D1071197at2759
OrthoFinder	1	1.000	-	-		FOG0000505
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830