DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RfC3 and rfc5

DIOPT Version :9

Sequence 1:	NP_609399.1	Gene:	RfC3 / 34423	FlyBaseID:	FBgn0032244	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001003862.1	Gene:	rfc5 / 445385	ZFINID:	ZDB-GENE-040907-1	Length:	334	Species:	Danio rerio

Alignment Length:	327	Identity:	206/327 - (62%)
Similarity:	255/327 - (77%)	Gaps:	1/327 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SETSGPAVRMPWVEKYRPSGLDDLISHEEIISTITRFISRKQLPHLLFYGPPGTGKTSTILACAR 66
            |:|...|..:||||||||..|||||||::|:|||.:|||..:|||||||||||||||||||||||
Zfish     5 SKTQPQARNLPWVEKYRPQTLDDLISHQDILSTIQKFISEDRLPHLLFYGPPGTGKTSTILACAR 69

  Fly    67 QLYSPQQFKSMVLELNASDDRGIGIVRGQILNFASTRTIFCDTFKLIILDEADAMTNDAQNALRR 131
            |||..::|.||||||||||||||.:|||.||:||||||||...|||:|||||||||.||||||||
Zfish    70 QLYKDKEFNSMVLELNASDDRGIDVVRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRR 134

  Fly   132 IIEKYTDNVRFCVICNYLSKIIPALQSRCTRFRFAPLSQDQMMPRLEKIIEAEAVQITEDGKRAL 196
            :|||:|:|.|||:|||||||||||||||||||||.||||:||:||||.:|:.|::.||.||.:|:
Zfish   135 VIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLSQNQMIPRLEHVIQQESIDITPDGMKAI 199

  Fly   197 LTLAKGDMRKVLNVLQSTVMAFDTVNEDNVYMCVGYPLRQDIEQILKALLSGSSLEDSFKTVESA 261
            :||:.||||:.||:||||.||:..|.|:.||.|.|:|||.||..||...|: .....::..:...
Zfish   200 VTLSTGDMRRSLNILQSTHMAYGKVTEETVYTCTGHPLRSDIANILDWALN-KDFTTAYNQILEL 263

  Fly   262 KYARGLALEDIITELHLFVMRLELPMSVMNKLIVKLAQIEERLAKGCTEVAQTAALVAAFFICRD 326
            |..:||||.||:||:||.:.|::.|.|:...|::|||.||.|||.|.:|..|.:::||||...||
Zfish   264 KTLKGLALHDILTEVHLLIHRVDFPPSIRMGLLIKLADIEYRLASGTSEKIQLSSMVAAFQAVRD 328

  Fly   327 MV 328
            :|
Zfish   329 IV 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RfC3	NP_609399.1	rfc	12..321	CDD:234763	198/308 (64%)
rfc5	NP_001003862.1	rfc	12..323	CDD:234763	198/311 (64%)
		AAA	29..170	CDD:99707	113/140 (81%)
		AAA_assoc_2	186..>214	CDD:292811	14/27 (52%)
		Rep_fac_C	252..321	CDD:285713	26/68 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580438
Domainoid	1	1.000	203	1.000	Domainoid score	I2927
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6730
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1822
OMA	1	1.010	-	-		QHG53599
OrthoDB	1	1.010	-	-		D1071197at2759
OrthoFinder	1	1.000	-	-		FOG0000505
OrthoInspector	1	1.000	-	-		oto40690
orthoMCL	1	0.900	-	-		OOG6_100321
Panther	1	1.100	-	-	LDO	PTHR11669
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1089
SonicParanoid	1	1.000	-	-		X3552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800