DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp31E and KIF20B

DIOPT Version :10

Sequence 1:NP_609398.2 Gene:Klp31E / 34422 FlyBaseID:FBgn0032243 Length:1048 Species:Drosophila melanogaster
Sequence 2:NP_001271188.1 Gene:KIF20B / 9585 HGNCID:7212 Length:1820 Species:Homo sapiens


Alignment Length:1352 Identity:305/1352 - (22%)
Similarity:526/1352 - (38%) Gaps:362/1352 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SEVDSINKDSSVRVAVRIRP--QNSREL--------IDMCRICTTVTLGEPQIFLG--SDKA--- 52
            :|.:|......::|.:||||  |:.:||        :|    ..||.|.|||..||  |:|:   
Human    48 TEANSFESKDYLQVCLRIRPFTQSEKELESEGCVHILD----SQTVVLKEPQCILGRLSEKSSGQ 108

  Fly    53 ----FTFDYVFDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESS 113
                |:|..||...:.|.:.:..|:.:.|...|.|.:..:..||.|.||||||    |....|: 
Human   109 MAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYT----FQGTEEN- 168

  Fly   114 DSVQLGIIPRAVRHIFSGIEQ-------------------------------------------- 134
                :||:||.:..:|..:::                                            
Human   169 ----IGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVH 229

  Fly   135 ------LEGSSTS------------EHPAA----GGSPQFSLAVQYIELYNEDIFDLLDP----F 173
                  |.||.|:            ::..|    ..|.:||:.|.:.|:|||.|:||..|    |
Human   230 NDSDDTLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKF 294

  Fly   174 NKNSNFKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFV 238
            .|....::.:|..|...|.......:....:|.:.|:.|...::.|.||:|:.|||||::||:.:
Human   295 QKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKI 359

  Fly   239 RRQRLLTPSDNVPDNDLETL--TSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCIS 301
            .:         :.|:::..:  .|:....|||||||..:||..|||.||..:||..||.||.||:
Human   360 LQ---------IEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCIN 415

  Fly   302 AL--GDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNI- 363
            .|  .:|||...|||:|:||||...|....|..:..||..:|.....:.||||.||::..|:.: 
Human   416 VLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480

  Fly   364 --------KNK----VKINQD-----QSSRTISQLRREIAALQLELLEYKQGK-LIVDCEG---- 406
                    :.|    ||.:||     .|:..|..::|...:.:..|.:..:.: |:.:.|.    
Human   481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEET 545

  Fly   407 ---NTTISD-----TFNENKLLLSE---------IKRLQQRLKSLQSTIATL------------- 441
               .|.:.|     |..|||..:|.         |:.|:::|.:.:....||             
Human   546 QNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFT 610

  Fly   442 ---TQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSP 503
               .||.||.|..|...:...::|::..:|        ..::|..|....||..|.:......:.
Human   611 QYWAQREADFKETLLQEREILEENAERRLA--------IFKDLVGKCDTREEAAKDICATKVETE 667

  Fly   504 RNAKPVYDSDIITKAK---KDLEREREL--LMSRSLPGIQNQNVSSE------ETEVASSDSEAE 557
            .....|...|||...:   .|::::.|:  |...|||..|......|      :.|:|.:..|..
Human   668 ETHNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELI 732

  Fly   558 EVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANM--- 619
            :..::|:..:|:.:   .||::||.:|.:........:|.::::..| |:|..|..::.::|   
Human   733 KTKEELKKRENESD---SLIQELETSNKKIITQNQRIKELINIIDQK-EDTINEFQNLKSHMENT 793

  Fly   620 --------TTSVSTPSK---DSLKKVKTDYESKISHMQTEIRKLQNAQRE--------HIRS--- 662
                    |:|:...:|   :...:|..|.:|||...:..:.:.:..|.|        |:.|   
Human   794 FKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAIT 858

  Fly   663 KQQLKSHEVR----------------------IGTLRNELNELKFAKVKLMKKMSQQSNRHKQEE 705
            :.|.||.|||                      :.|:.|||...|..|.:|.|    |....:||.
Human   859 EDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNK----QIVHFQQEL 919

  Fly   706 SRKSKEIAQLLKE-QRRQKN---AVLTLEAKVS----AKEQILKRKTEEVIALR---------KS 753
            |...|:...|.|| |:.|.|   |:..|..:.|    .:|:|:|...|...|.|         |.
Human   920 SLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKL 984

  Fly   754 QRGKSGQRAPAHLTSKIATLDGFSTR--------------------------------------- 779
            ...|..:.......|:|:.:|..:.|                                       
Human   985 MHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNR 1049

  Fly   780 ------SARHRWENLYRNILHAARNRQLITQLEKELERLILEREDLSRELNIMENGQTADRQTDE 838
                  |....||.....:..:::....|.:||:::|:|..|.:....|.|.:       ::.:.
Human  1050 ENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRL-------KEKEH 1107

  Fly   839 FNEVDNLKTNISYIQE--------------NIEHV---QQAIMEFEDTKDTVQSHVNKIQSLLD- 885
            .|:.|.||...:.||:              .|:||   ::|:.|........::.:.:::::|: 
Human  1108 KNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET 1172

  Fly   886 -EVSTVAEAKF---ILQKFSDTAIVMSCNLAIAESHLQE-----KESLLKEVKQESGIQQ----- 936
             :|.....||.   ||:|.| ..:.:..||...:.|||:     |:..:||:|.:..|.|     
Human  1173 QKVECSHSAKLEQDILEKES-IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNL 1236

  Fly   937 QILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLISNATYDIPQ-----DDKNSEFHQ 996
            |.::|.|.........:..::..||....|||....:.|:.:.....|...     .|...:..|
Human  1237 QDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQ 1301

  Fly   997 VEMRRTTSRSPSPLGNSDPFDKSPKVR-RRTAKRQDLLFGDTELSEQTFNKM 1047
            |:...:..|..         ||..::: ....|:::....:.::.::|..::
Human  1302 VQKEVSVMRDE---------DKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp31ENP_609398.2 KISc_KIF4 12..364 CDD:276823 128/453 (28%)
Mplasa_alph_rch <372..>748 CDD:275316 104/484 (21%)
SMC_prok_B 622..>899 CDD:274008 79/396 (20%)
Rcc_KIF21 798..870 CDD:410202 19/88 (22%)
KIF20BNP_001271188.1 KISc_KIF23_like 57..477 CDD:276819 127/441 (29%)
RBD_KIF20B 600..654 CDD:409644 10/61 (16%)
Mplasa_alph_rch 740..1350 CDD:275316 123/630 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..866 7/36 (19%)
Necessary and sufficient for interaction with SHTN1. /evidence=ECO:0000250|UniProtKB:Q80WE4 1050..1107 11/63 (17%)
SMC_prok_B <1077..1381 CDD:274008 56/285 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1247..1275 5/27 (19%)
Smc <1280..>1583 CDD:440809 9/74 (12%)
PTZ00108 <1501..1792 CDD:240271
Interaction with PIN1. /evidence=ECO:0000269|PubMed:11470801 1560..1820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1760..1781
Blue background indicates that the domain is not in the aligned region.

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