Protein Alignment Klp31E and Kif3c

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_445938.1
• Gene: Kif3c / 85248
• RGDID: 621538
• Length: 796
• Species: Rattus norvegicus
• Alignment Length: 871
• Identity: 240/871 - (27%)
• Similarity: 384/871 - (44%)
• Gaps: 174/871 - (19%)

  Fly    13 SVRVAVRIRPQNSRE-------LIDMCRICTTVTLGEPQIFLGS-DKAFTFDYVFDTNSNQCDIY 69
            :::|..|.||.:.:|       ::.|......|||..|:...|. .|.||||.|:|.:|.|.|:|
  Rat    10 ALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLY 74

  Fly    70 SDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTM-GTGFDHESESSDSVQLGIIPRAVRHIFSGIE 133
            .:.|..|:||.|.|:|.||.||||||:|||||| ||..:.|..       |:||.|..|||:
  Rat    75 DETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELR-------GVIPNAFEHIFT--- 129

  Fly   134 QLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLL--DP-----FNKNSNFKIH-EDASGQIT 190
                     |.:...:.|:.:...|:|:|.|:|.|||  :|     ..:|....:: :|.|..:|
  Rat   130 ---------HISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVT 185

  Fly   191 ISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDL 255
            .:...|:.:         :..|..||...||.||:.||||||:|.|.|.      .|:...|...
  Rat   186 KNVKEIEHV---------MNLGNQARAVGSTHMNEVSSRSHAIFVITVE------CSERGSDGQD 235

  Fly   256 ETLTSKFHFVDLAGSERLKR----------TQAT----------------GERAREGISINCGLL 294
            .....|.:.||||||||..:          ||:|                |||.:|...||..|.
  Rat   236 HIRVGKLNLVDLAGSERQNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLS 300

  Fly   295 ALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANR 359
            ||||.|:||.  ..|:.|:||||||||||||||||||::|:|:|.:.|:...:.|:|:||::|||
  Rat   301 ALGNVIAALA--GNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANR 363

  Fly   360 ARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEI 424
            |:|||||.::|:|.....:.:.:.|||.|:.:|                       |.|.:|.:.
  Rat   364 AKNIKNKPRVNEDPKDTLLREFQEEIARLKAQL-----------------------EKKGMLGKR 405

  Fly   425 KRLQ--QRLKSLQSTIATLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLE--IEELQTKL 485
            .|.:  :|.|::.:.        |.......:..|.:::..|........|..||  :|:.....
  Rat   406 PRRKSSRRKKAVSAP--------AGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAALEKNMENY 462

  Fly   486 IESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVA 550
            ::.::.|.:.|..|...        |..::::.|:.|..|:|    :.|..::.:..::|.....
  Rat   463 LQEQKERLEEEKAAIQD--------DRSLVSEEKQKLLEEKE----KMLEDLKREQQATELLAAK 515

  Fly   551 SSDSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDV 615
            ....|::.::.....:|:..|.:    :.|||......:.:....|....:..:.|.|.:
  Rat   516 YKAMESKLLIGGRNIMDHTNEQQ----KMLELKRQEIAEQKRREREMQQEMLLRDEETME----- 571

  Fly   616 LANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNEL 680
            |....:|:....:...||:|..| :|:..::.||   |:...|:||.:|.|:..:      ..:.
  Rat   572 LRGTYSSLQQEVEVKTKKLKKLY-AKLQAVKAEI---QDQHEEYIRVRQDLEEAQ------NEQT 626

  Fly   681 NELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTE 745
            .|||...:.:       .|....||..|......|..|:.:.|...| :.|.|: ..|:.||.|.
  Rat   627 RELKLKYLII-------ENFIPPEEKNKIMNRLFLDCEEEQWKFQPL-VPAGVN-NSQMKKRPTS 682

  Fly   746 EVIALRKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLE---- 806
            .|           |.:.|....:::|...|   ...|:|.||:.  .|....:...|.::|
  Rat   683 AV-----------GYKRPISQYARVAMAMG---SHPRYRAENIM--FLELDVSPPAIFEMEFSHD 731

  Fly   807 KELERLILEREDLSRELNIMENGQTA 832
            :|.:..:|..|.|.|..:.:|...|:
  Rat   732 QEQDPRVLHMERLMRLDSFLERPSTS 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	146/393 (37%)
		Mplasa_alph_rch	<372..>748	CDD:275316	70/379 (18%)
		SMC_prok_B	622..>899	CDD:274008	50/215 (23%)
		Rcc_KIF21	798..870	CDD:410202	9/39 (23%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	145/392 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..292		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421		6/31 (19%)
		Smc	<452..>637	CDD:440809	39/222 (18%)
		Globular. /evidence=ECO:0000255	633..793		33/150 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..796		1/4 (25%)