DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and AT5G60930

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001332385.1	Gene:	AT5G60930 / 836214	AraportID:	AT5G60930	Length:	1335	Species:	Arabidopsis thaliana

Alignment Length:	1081	Identity:	353/1081 - (32%)
Similarity:	545/1081 - (50%)	Gaps:	189/1081 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQC-DIYSDCVEKLV 77
            |||||.|||..:.||::.|..|.||...|||:.:|| ..||:|:|:......| :||:.||..||
plant     7 VRVAVNIRPLITPELLNGCTDCITVAPKEPQVHIGS-HTFTYDFVYGNGGYPCSEIYNHCVAPLV 70

  Fly    78 DSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSE 142
            |:...||||||||||||||||||||||.:     |.|....|:||..:..||..:|..:.||
plant    71 DALFKGYNATVLAYGQTGSGKTYTMGTNY-----SGDCTNGGVIPNVMEDIFRRVETTKDSS--- 127

  Fly   143 HPAAGGSPQFSLAVQYIELYNEDIFDLLDPFN----KNSN-------------FKIHEDASGQIT 190
                    :..:.|.:||::.|::|||||..:    ||.:             .:|.|.|||.||
plant   128 --------ELLIRVSFIEIFKEEVFDLLDSNSSALLKNDSGVQAKHTALSRAPIQIRETASGGIT 184

  Fly   191 ISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPS-DNVPDND 254
            ::|.:...:....:...:|.:|:|:|.|.||.||.|||||||:|||.:.::::...| ....|..
plant   185 LAGVTEAEVKTKEEMGSFLARGSLSRATGSTNMNSQSSRSHAIFTITLEQKKIAGGSCTTTEDGG 249

  Fly   255 LETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKR--ALHVPYRD 317
            .:.|.:|.|.||||||||.|||.|.|.|.:|||.||.|||||||.||||||:.||  ..||||||
plant   250 EDILCAKLHLVDLAGSERAKRTGADGMRLKEGIHINKGLLALGNVISALGDEKKRKEGGHVPYRD 314

  Fly   318 SKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLR 382
            |||||||||||||||:|:|||||||:|.:..|||||||||||||||:||..||:|.::..:.::|
plant   315 SKLTRLLQDSLGGNSKTVMIACVSPADTNAEETLNTLKYANRARNIQNKAVINRDPATAQMQRMR 379

  Fly   383 REIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIAT------- 440
            .:|..||.|||.|:         |:   |..|:|.::|..:|..|:...:.|.:.:..
plant   380 SQIEQLQTELLFYR---------GD---SGAFDELQILKHKISLLEASNRELHNELQERRVASEH 432

  Fly   441 LTQRNADLKTNLD--------------LNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEH 491
            .::|..|.:...|              |::..|..|.||.:   |.:|:.:|:||:.:|:    |
plant   433 FSKRAYDAQVEKDKLIMIIESVRNGKSLDEIESCQNEDVGL---VNKYVSKIQELEGELL----H 490

  Fly   492 RKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNV---SSEETEVASSD 553
            .|  .:|.|::.:.:...||                       .|.::.||   ||.|    |||
plant   491 IK--NLKKTSNHQYSDDSYD-----------------------VGPRSNNVLFPSSNE----SSD 526

  Fly   554 SEAE--EVVKDLEAIDNDIE---MRTKLIEQLELTNSRYEQ---------------MRTHYEEKL 598
            .|.:  :|..:||..:.:||   ::.||..:|:..:.|.|:               ::.|||:|:
plant   527 CEDKVMDVTDELEFQEKEIEHCSLQEKLDMELKELDKRLEEKEAEMKRFSSGGTSVLKQHYEKKV 591

  Fly   599 SVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEI---RKLQNAQREHI 660
            ..|..:....|:|.:.:..|:.:..|.|. |..:|:|.:|..|::.::|::   :|.|:||.:.:
plant   592 YDLEQEKRALQREIEGLRHNLASIPSGPG-DGAQKLKEEYVQKLNTLETQVSVLKKKQDAQAQLM 655

  Fly   661 RSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNA 725
            |.||  ||.:..| .|::|::.:|..||:|.:|:.|:|.:.:..::.:.||:.||.||.||.:..
plant   656 RQKQ--KSDDAAI-KLQDEIHRIKSQKVQLQQKIKQESEQFRAWKASREKEVMQLKKEGRRNEYE 717

  Fly   726 VLTLEAKVSAKEQILKRKTEEVIALRKSQRGKSGQRAPAHLTSKIATLDGFS-------TRSARH 783
            :..|.|....::.:|:|||||...:.|..:.....|.    .|...||.|.:       .::..|
plant   718 MHKLMALNQKQKLVLQRKTEEASQVTKRLKELLDNRK----ASSRETLSGANGPGTQALMQAIEH 778

  Fly   784 RWENLYRNILHAARN---RQL--ITQLEKELERLILEREDLSRELNIMENGQTAD---RQTDEFN 840
            ..|...|  :|..|:   ||.  ..::.||:.|| .|..:|.:...|..:|.|..   |.:..|.
plant   779 EIEVTVR--VHEVRSEYERQTEERARMAKEVARL-REENELLKNAKISVHGDTMSPGARNSRIFA 840

  Fly   841 EVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAI 905
            ..:.|.|:.|    .:..:...:.|.|:     :..|...:...::|.|:.:||.|:....:.|.
plant   841 LENMLATSSS----TLVSMASQLSEAEE-----RERVFGGRGRWNQVRTLGDAKSIMNYLFNLAS 896

  Fly   906 VMSCNLAIAESHLQEKESLLKEVKQE----------SGIQQQILQHFLSQNSNVHIADIFDSLNL 960
            ...|.....|:..:||:.|::::|::          ..||:..|.|.:...::. :..:....||
plant   897 TARCLARDKEADCREKDVLIRDLKEKIVKFSSYVRYMEIQKADLVHQVKAQTSA-MKKLSADENL 960

  Fly   961 KGSNIASSVNPGSQKSLISNATY---DIPQDDKNSEFHQVE 998
            |..:       ..:|....|:|.   |:...|..:..|:.|
plant   961 KNEH-------SMKKQETRNSTIVLEDMDTSDSEASDHERE 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	184/370 (50%)
		KISc	13..370	CDD:214526	187/376 (50%)
		KASH_CCD	409..589	CDD:291334	46/208 (22%)
		RasGAP	<685..750	CDD:295371	22/64 (34%)
AT5G60930	NP_001332385.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	292	1.000	Domainoid score	I357
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2528
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.670