DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and MRH2

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001326426.1	Gene:	MRH2 / 824652	AraportID:	AT3G54870	Length:	1051	Species:	Arabidopsis thaliana

Alignment Length:	1081	Identity:	281/1081 - (25%)
Similarity:	482/1081 - (44%)	Gaps:	236/1081 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVDSINKDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFL-------GSDKAFTFDYVFDT 61
            :.|..|....|||:||:||:|..|||........|.| :|:|..       .:.:::.||.||..
plant    95 DFDDDNDPGRVRVSVRVRPRNGEELISDADFADLVEL-QPEIKRLKLRKNNWNSESYKFDEVFTD 158

  Fly    62 NSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMG-TGFDHESESSDSVQLGIIPRAV 125
            .::|..:|....:.:|:..|.|||.|::||||||:|||||:| .|.|      |:.:.||:.||:
plant   159 TASQKRVYEGVAKPVVEGVLSGYNGTIMAYGQTGTGKTYTVGKIGKD------DAAERGIMVRAL 217

  Fly   126 RHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDA-SGQI 189
            ..|.     |..||.|          .|:.:.|::||.|.|.|||.|  :.:|..|:||| :|::
plant   218 EDIL-----LNASSAS----------ISVEISYLQLYMETIQDLLAP--EKNNISINEDAKTGEV 265

  Fly   190 TISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRR----QRLLTPSDNV 250
            ::.||::..|......|:.||.|...|..|:||||.:||||||:.|::|||    :......:::
plant   266 SVPGATVVNIQDLDHFLQVLQVGETNRHAANTKMNTESSRSHAILTVYVRRAMNEKTEKAKPESL 330

  Fly   251 PDNDLETL-TSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVP 314
            .|..:..: .||...||||||||:.::...|....|...||..|.:||.||:||.:.|.   |:|
plant   331 GDKAIPRVRKSKLLIVDLAGSERINKSGTDGHMIEEAKFINLSLTSLGKCINALAEGSS---HIP 392

  Fly   315 YRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTIS 379
            .|||||||||:||.||:::|.:|..:.||.|...||.:|:.:..||..|.|.||:.::....::.
plant   393 TRDSKLTRLLRDSFGGSARTSLIITIGPSARYHAETTSTIMFGQRAMKIVNMVKLKEEFDYESLC 457

  Fly   380 QLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQR 444
            :           .||.:...|..:.|         .:|||..||...|::||:..:::.|. .::
plant   458 R-----------KLETQVDHLTAEVE---------RQNKLRNSEKHELEKRLRECENSFAE-AEK 501

  Fly   445 NADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPV 509
            ||     :..:|:...:|:.:|::.......|::::.|..|:..:..:.:|::|.|...:.....
plant   502 NA-----VTRSKFLEKENTRLELSMKELLKDLQLQKDQCDLMHDKAIQLEMKLKNTKQQQLENSA 561

  Fly   510 YDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMRT 574
            |::.:...::...::..||:          |.|..|:....:::.:..|       :.|.:..:.
plant   562 YEAKLADTSQVYEKKIAELV----------QRVEDEQARSTNAEHQLTE-------MKNILSKQQ 609

  Fly   575 KLIEQLELTNSRYEQ---MRTH-YEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVK 635
            |.|.:.|..|.:|::   ..|| ||.|::.|..|:|.....            |..::|.|:::|
plant   610 KSIHEQEKGNYQYQRELAETTHTYESKIAELQKKLEGENAR------------SNAAEDQLRQMK 662

  Fly   636 TDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIG---TLRNELNELKFAKVKLMKKMSQQ 697
                ..||..|...::.:.|....|:.::..:.:|..:.   |::.:.::|...|.||.:::...
plant   663 ----RLISDRQVISQENEEANELKIKLEELSQMYESTVDELQTVKLDYDDLLQQKEKLGEEVRDM 723

  Fly   698 SNRHKQEESRKSK---EIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQRGK-- 757
            ..|...||.::.:   |:::|.|..|..:|.|   |.|...||.:.|...|.. |...|||.:
plant   724 KERLLLEEKQRKQMESELSKLKKNLRESENVV---EEKRYMKEDLSKGSAESG-AQTGSQRSQGL 784

  Fly   758 ----SGQRAP-AHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKELERLILERE 817
                |||||. |.|..::.                                 ::|.|:  :::.|
plant   785 KKSLSGQRATMARLCEEVG---------------------------------IQKILQ--LIKSE 814

  Fly   818 DLSRELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQS 882
            ||  |:.|......|:...:|.|:|       ..::|.  .|:..:|       .|||..|   |
plant   815 DL--EVQIQAVKVVANLAAEEANQV-------KIVEEG--GVEALLM-------LVQSSQN---S 858

  Fly   883 LLDEVSTVAEAKFILQKFSDTAIVMSCN-------------------LAIAESHLQEKESLLKEV 928
            .:..|::.|.|...:.:.|...|:....                   :|.|.::|...|..||.:
plant   859 TILRVASGAIANLAMNEKSQDLIMNKGGAQLLAKMVTKTDDPQTLRMVAGALANLCGNEKFLKLL 923

  Fly   929 KQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNIAS----SVNPGSQKS------------L 977
            |:|.||:..:.   ::|:.|:   ||...:....:|.|.    .:..|.:|.            |
plant   924 KEEEGIKGLLT---MAQSGNI---DIIAQVARGMANFAKCETREIMQGRRKGRSLLLEEGVLEWL 982

  Fly   978 ISNATYD--------------IPQDDKNSEFHQVEMRRTTS 1004
            .||:..|              :.|:::|:.    :.:||.|
plant   983 TSNSHIDSASTQRHIELALCHLAQNEENAN----DFKRTGS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	138/365 (38%)
		KISc	13..370	CDD:214526	142/370 (38%)
		KASH_CCD	409..589	CDD:291334	33/179 (18%)
		RasGAP	<685..750	CDD:295371	18/67 (27%)
MRH2	NP_001326426.1	KISc	121..439	CDD:276812	126/344 (37%)
		Smc	472..>757	CDD:224117	66/335 (20%)
		COG4372	647..>869	CDD:226809	62/297 (21%)
		armadillo repeat	804..829	CDD:293788	8/28 (29%)
		armadillo repeat	836..873	CDD:293788	12/55 (22%)
		armadillo repeat	878..913	CDD:293788	3/34 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910