DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and KICP-02

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_566931.1	Gene:	KICP-02 / 824186	AraportID:	AT3G50240	Length:	1051	Species:	Arabidopsis thaliana

Alignment Length:	1064	Identity:	339/1064 - (31%)
Similarity:	530/1064 - (49%)	Gaps:	199/1064 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEVDSINKDS-SVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQC 66
            |...|::.:| .|:|||.:||....|:...||.|.:|:...||:.:|: ..||||:|:.:|.:..
plant    14 SPPSSLSSESCCVKVAVNVRPLIGDEVTQGCRECVSVSPVTPQVQMGT-HPFTFDHVYGSNGSPS 77

  Fly    67 DI-YSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFS 130
            .: :.:||..|||...||||||||||||||||||||||||.      .|..:.|:||:.:..:|:
plant    78 SLMFEECVAPLVDGLFHGYNATVLAYGQTGSGKTYTMGTGI------KDGTKNGLIPQVMSALFN 136

  Fly   131 GIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLD---PFNKNSN------------FK 180
            .|:.:      :|...     |.|.|.:||:..|::.||||   |||:.:|            .:
plant   137 KIDSV------KHQMG-----FQLHVSFIEILKEEVLDLLDSSVPFNRLANGTPGKVVLSKSPVQ 190

  Fly   181 IHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLT 245
            |.|..:|.||:|||:..||....:....|:||:|.|.|.||.||::||||||:|||.:.:.|.::
plant   191 IRESPNGVITLSGATEVPIATKEEMASCLEQGSLTRATGSTNMNNESSRSHAIFTITLEQMRKIS 255

  Fly   246 P----SDNVPDNDL--ETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALG 304
            .    .|.| |.|:  |...:|.|.||||||||.|||.:.|.|.:|||.||.|||||||.|||||
plant   256 SISVVKDTV-DEDMGEEYCCAKLHLVDLAGSERAKRTGSGGVRLKEGIHINRGLLALGNVISALG 319

  Fly   305 DKSKR--ALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKV 367
            |:.:|  ..|||||||||||||||||||||:|:||||:||:|.:..|||||||||||||||:||.
plant   320 DEKRRKEGAHVPYRDSKLTRLLQDSLGGNSKTVMIACISPADINAEETLNTLKYANRARNIQNKP 384

  Fly   368 KINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLK 432
            ..|:|                                              |:.||:::::|.|:
plant   385 VANKD----------------------------------------------LICSEMQKMRQELQ 403

  Fly   433 SLQSTIATLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIE----SEEHRK 493
            .||   |||..|.|           ||.:               |::.::.|:::    :||..:
plant   404 YLQ---ATLCARGA-----------TSSE---------------EVQVMREKIMKLESANEELSR 439

  Fly   494 QMEI----KATTSPRNAKPVYDSDIITK---AKKDLE-RERELLMSRSLPGIQNQNV-SSEETEV 549
            ::.|    :.|....|.....|..|.:|   .|:..| .:.:..||.:..|..:::: ::||.|.
plant   440 ELHIYRSKRVTLDYCNIDAQEDGVIFSKDDGLKRGFESMDSDYEMSEATSGGISEDIGAAEEWEH 504

  Fly   550 A----SSDSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQK 610
            |    |...|..|:.|.||  :.:.|||        :.....|.:|.|:|:|:..|..:....|.
plant   505 ALRQNSMGKELNELSKRLE--EKESEMR--------VCGIGTETIRQHFEKKMMELEKEKRTVQD 559

  Fly   611 ERDDVLANMTTSVSTPSKDSLKKVKTD-YESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIG 674
            |||.:||.:....:  |.|...:|..| :..|:..::|:|..|:..|...:...:|.:..|....
plant   560 ERDMLLAEVEELAA--SSDRQAQVARDNHAHKLKALETQILNLKKKQENQVEVLKQKQKSEDAAK 622

  Fly   675 TLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQI 739
            .|:.|:..:|..||:|.:||.|::.:.:|.::.:.||:.||.||.|:.::..|.|||....::.:
plant   623 RLKTEIQCIKAQKVQLQQKMKQEAEQFRQWKASQEKELLQLKKEGRKTEHERLKLEALNRRQKMV 687

  Fly   740 LKRKTEE-VIALRKSQRGKSGQRAPAHLTSKIATLDGFSTRS---ARHRWENLYRNILHAARNRQ 800
            |:||||| .:|.::.:.....:::..|..|.||.....|.::   :..:|  |...:...|:..|
plant   688 LQRKTEEAAMATKRLKELLEARKSSPHDISVIANGQPPSRQTNEKSLRKW--LDNELEVMAKVHQ 750

  Fly   801 LITQLEKELE---RLILEREDLSRELNIMENGQTADRQTDEF-------NEVDNLKTNISYIQEN 855
            :..|.||:::   .|.:|...|.:|:....|..........|       ..:.:|::.:......
plant   751 VRFQYEKQIQVRAALAVELTSLRQEMEFPSNSHQEKNGQFRFLSPNTRLERIASLESMLDVSSNA 815

  Fly   856 IEHVQQAIMEFEDTKDTVQS--HVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHL 918
            :..:...:.|.|:.:.::.:  ..|.|||:.|       ||::||...|:.       |.|.|.:
plant   816 LTAMGSQLSEAEEREHSLHAKPRWNHIQSMTD-------AKYLLQYVFDST-------AEARSKI 866

  Fly   919 QEKESLLKEVKQE----------SGIQ-QQILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPG 972
            .||:..:||.|::          :.:| ::||:...::...|.||....|.:..||:.:||.:.|
plant   867 WEKDRDIKEKKEQLNDLLCLLQLTEVQNREILKEKKTREQTVSIALASTSSSYSGSSRSSSKHYG 931

  Fly   973 SQKSLISNATYDIPQDDKNSEFHQ 996
            .     :||:.|  ....:|.:|:
plant   932 D-----NNASDD--PSSPSSTYHR 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	183/376 (49%)
		KISc	13..370	CDD:214526	185/380 (49%)
		KASH_CCD	409..589	CDD:291334	42/196 (21%)
		RasGAP	<685..750	CDD:295371	24/65 (37%)
KICP-02	NP_566931.1	KISc_KIF4	24..381	CDD:276823	182/375 (49%)
		KISc	26..387	CDD:214526	185/379 (49%)
		iSH2_PI3K_IA_R	545..>666	CDD:304922	33/122 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	292	1.000	Domainoid score	I357
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2528
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.670