Protein Alignment Klp31E and kif14

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_005170522.2
• Gene: kif14 / 562052
• ZFINID: ZDB-GENE-030131-5759
• Length: 1506
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 296/1179 - (25%)
• Similarity: 505/1179 - (42%)
• Gaps: 313/1179 - (26%)

  Fly    10 KDSSVRVAVRIRPQNSRELID-MCRICTTVTLGEPQIFLGSDKA------------FTFDYVFDT 61
            ::|:|.||||:||.:|||..: .|::          ||:.:...            ||||:.| .
Zfish   232 ENSAVTVAVRVRPFSSREKNEKACQV----------IFMENQDTLVQHPDTKQTHKFTFDFSF-C 285

  Fly    62 NSNQCD--------IYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQL 118
            :.|:.|        ||......|::....|:|..:.|||||||||:||| .||..|:
Zfish   286 SINEADASFSSQQLIYEKLARPLLERAFDGFNTCLFAYGQTGSGKSYTM-MGFGEET-------- 341

  Fly   119 GIIPRAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLL---DPFN-KNSNF 179
            |:|||....:||.:.:.|....|.|          |.:.|.|:|||.|.|||   |..| |....
Zfish   342 GVIPRFCEELFSRLARSETKEMSCH----------LEMSYFEVYNEKIHDLLVAKDEQNQKKMPL 396

  Fly   180 KIHEDASGQITISGASIKPIYQPH-------------DALKYLQQGALARTTASTKMNDQSSRSH 231
            ::.|             .|:|.|:             |...:|:.|...|.||:|.|||:|||||
Zfish   397 RVRE-------------HPVYGPYVADLSTNVVSSYSDIKTWLELGNKQRATAATGMNDKSSRSH 448

  Fly   232 ALFTIFVRRQRLLTPSDNVPDNDLE-TLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLA 295
            ::||:.:.:    |.::.|.:.:.: .:||:.:.||||||||....|.:|:|.|||.|||..||.
Zfish   449 SVFTLVMTQ----TKTEFVEEEEHDHCITSRINLVDLAGSERCTSAQTSGDRLREGASINKSLLT 509

  Fly   296 LGNCISALGD--KSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYAN 358
            ||..||:|.:  :|::.:..|||:|.||.||::||||||:|.|||.:||:..:..|:|:||:||.
Zfish   510 LGKVISSLSEQSQSRKKVFTPYRESVLTWLLKESLGGNSKTAMIATLSPAASNMEESLSTLRYAQ 574

  Fly   359 RARNIKNKVKINQDQSSRTISQLRREIAAL------------------QLELLEYKQGKLIVDCE 405
            :||.|.|..|:|:|.:::.|..|:.|:..|                  |.|:...| .||   |:
Zfish   575 QARMIINIAKVNEDTNAKLIRDLKAEVEKLRAAQMSSQGVEPEKMRLFQQEIAALK-NKL---CQ 635

  Fly   406 GNTTISDTFNENKLLLSEI-KRLQQRLKSLQSTIATLTQRNADLKTNLDLNKWTSDDNSDVEIAK 469
            ....:::.....|..|.|. :|.::..|.||....|....|. |...::||:       |.::::
Zfish   636 QEHEMAEAHRTWKEKLEEAERRKREEAKELQRAGVTFKVDNR-LPNLVNLNE-------DPQLSE 692

  Fly   470 VVGQYMLEIEELQTKL--IESE--------------EHRKQMEIKATTSPR---NAKPVYDSDII 515
            :: .||  |:|.|||:  ::||              :|.....:|.|.|.:   |||...:..::
Zfish   693 ML-LYM--IKEGQTKVGKLKSESAHDIQLSGALIADQHCVISSVKGTVSIKPMPNAKTFVNGHLV 754

  Fly   516 TKAKKDLERERELLMSRSLPGIQNQNVSSEETEVAS-------SDSEAEEVVKDLEAIDNDI--- 570
            ::.......:|.:|      |..:....:...||.|       |..:..   ||.|...|::
Zfish   755 SECTVLHHGDRVIL------GGDHYFRFNHPAEVQSGKRASCWSSGDGH---KDFEFAKNELLSA 810

  Fly   571 ----------EMRTKLIEQL--------ELTNSRYEQMRTHYEEKLSVLYCKI-ENTQKERDDVL 616
                      |.|.|..|::        |:......:.::.||.|:..|..:: |.::::|:..|
Zfish   811 QRAQLEAEIQEARLKAKEEMMQGIQVAKEMAQKELSEQKSLYEIKIRALERELKEESERKREQEL 875

  Fly   617 ANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVR----IGTLR 677
            .....:...   :.|:.|||..|.::|   :..|:|   |.|...::|.:..|:||    :..|.
Zfish   876 HKQRAASQI---EQLQSVKTLLEKEVS---SHKRRL---QMEAQATRQAMADHDVRHAKIVAALE 931

  Fly   678 NELN---------ELKFA-----------------KVKLM----KKMSQQSNRH----KQEESRK 708
            .|..         |:|.|                 |:.||    .|:|.:..:|    :.|.:.|
Zfish   932 AEKRKIAEDLAQIEMKRALKVTQTPKMAIPQWDAMKLSLMIEEANKISGKLRKHTVFSRHEAADK 996

  Fly   709 SKE--IAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQRGKSGQRA--------- 762
            ..|  .|||..:.:..|..:.|..:        |::....:.|:|:.::|:|..:.
Zfish   997 EVEGGDAQLQVQVQNTKLGISTFWS--------LEKFQSNLAAMREIEQGESASKDDDVFYDPND 1053

  Fly   763 --PAHLTSKIATLDGFSTRSAR-----------------HRWENLYRN------------ILHAA 796
              ...|::..:| ..||.|.:|                 |..::|:..            .||::
Zfish  1054 EWEPDLSASSST-SSFSRRRSRSLLKSRRISGRLYEIRVHPIQSLHCTPSQSTGLMNKPPSLHSS 1117

  Fly   797 RNRQLITQLEKELERLILEREDLSRELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQ 861
            .:...:..:.|:|....:.|  |....:..|:...||:.|.:...|.....:|:.:.|:::
Zfish  1118 TSDSALPGICKDLIGSAVAR--LRSCQSADESESLADKLTLDLLSVHRAVRSITDLYEDLD---- 1176

  Fly   862 AIMEFEDTKDTVQSHVNKIQS-LLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHLQEKESLL 925
                 :|:::.:.:...:.|: |:...|.|..|.||...:..:....|..::      |..|.|.
Zfish  1177 -----DDSEENLFACSTEAQTHLVKATSAVERAVFITMHWVSSITFGSITVS------QRAEELK 1230

  Fly   926 KEVKQESGIQQQILQHFLSQNSNV------HIADIFDSLNLKGSNIASSVNPGSQKSLISNATYD 984
            .|||:..|..|.::|...|:.|::      .:|:..::: .|.....::|| |:          |
Zfish  1231 MEVKKIGGYLQLLIQGCDSEISSMVTEARKRVAECINAV-FKTIGFLAAVN-GT----------D 1283

  Fly   985 IPQDDKNSE 993
            :..:::|||
Zfish  1284 LHLNEQNSE 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	141/392 (36%)
		Mplasa_alph_rch	<372..>748	CDD:275316	97/482 (20%)
		SMC_prok_B	622..>899	CDD:274008	67/357 (19%)
		Rcc_KIF21	798..870	CDD:410202	12/71 (17%)
kif14	XP_005170522.2	None