Protein Alignment Klp31E and KIF27

DIOPT Version :9

• Sequence 1: NP_001162935.1
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_011517150.1
• Gene: KIF27 / 55582
• HGNCID: 18632
• Length: 1427
• Species: Homo sapiens
• Alignment Length: 1244
• Identity: 330/1244 - (26%)
• Similarity: 534/1244 - (42%)
• Gaps: 342/1244 - (27%)

  Fly    14 VRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEKLVD 78
            |:|||||||...:|.:...::|..|.....|:.:|.|:.||||:||..||.|.::|:.|::.||.
Human     6 VKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVL 70

  Fly    79 STLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEH 143
            |.:.||||||.||||||||||||:|.|  |.:...:. |.||||||::.||..|        |||
Human    71 SLIEGYNATVFAYGQTGSGKTYTIGGG--HIASVVEG-QKGIIPRAIQEIFQSI--------SEH 124

  Fly   144 PAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQPHDALKY 208
            |    |..|::.|.|||:|.||:.|||:......:..|.||..|...|.||....:....:.:..
Human   125 P----SIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAGEVMSL 185

  Fly   209 LQQGALARTTASTKMNDQSSRSHALFTIFV-RRQRLLTPSDNVPDNDLETLTSKFHFVDLAGSER 272
            |:.|..||.|.:|:||:.||||||:|||.: :..:.:..:::........:.|||||||||||||
Human   186 LEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKFHFVDLAGSER 250

  Fly   273 LKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMI 337
            :.:|..||||.:|.|.||.|||||||.||||||..:::.|:||||:|:||||:|||||:::|:||
Human   251 VTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMI 315

  Fly   338 ACVSPSDRDFMETLNTLKYANRARNIKNK------------------------------------ 366
            .|||||..:|.|:||:||||||||||:||
Human   316 TCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQT 380

  Fly   367 VKINQDQSSRT--ISQLRREIAALQLELLEY-----KQGKLIVDCEGNTTISD------------ 412
            .:||::.|..|  |..|..::|.||.|.|.|     :....:||.:....:::
Human   381 TQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNM 445

  Fly   413 -------------------------------------------------TFNENKLLLSEIKRLQ 428
                                                             .||:.:|.:.|:|...
Human   446 IQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQV 510

  Fly   429 Q--------------------RLKSLQSTIATLTQRNADLK-TNLDLNKWTSDDNSDVEIAKVVG 472
            |                    ||:.|..|  ||...:.||. .|:..| |...:...:|...:|.
Human   511 QMMVQENKGHAVSLKEAQKVNRLQPLAKT--TLLSTSMDLPILNISYN-WNHTNEKIIEQQLLVD 572

  Fly   473 QYMLEIEELQTKLIESEEHR-------------------------------KQMEIKATTSPRNA 506
            |...|:.:|...:..|.:..                               :|...|..|||
Human   573 QLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSP--- 634

  Fly   507 KPVYDSDII-----TKAKK---DLERERELL---------------------MSRSLPGIQNQN- 541
             |:|..|.|     |:::.   .:|.:.::|                     ..||...||..:
Human   635 -PMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDS 698

  Fly   542 ------VSSEETEVASSDSEAEEVVKD---------LEAIDN-----------------DIEMRT 574
                  :|..:.|...||.|.|::..|         |:.:.|                 :|:|:.
Human   699 VCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKE 763

  Fly   575 KLIEQLELTNSRYEQMRTHYEEKLSVL-----YCKIE--NTQKERDDVLANMTTSVSTPSKDSLK 632
            .||::|..|.:..:.:...|..|::.|     ..|:|  .|||:..: |.|...|      |...
Human   764 DLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQE-LENKDLS------DVAM 821

  Fly   633 KVK--TDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMS 695
            |||  .::..|:...:..::.||..|::..:.......:|.|...|...::.:|:.|::|.:|:
Human   822 KVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKL- 885

  Fly   696 QQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALR-KSQRGKSG 759
                   :||:.|.|::..::|   |.:..:..::.| :.:|:.||.|.|::.|.. |.::|..|
Human   886 -------REENEKRKQLDAVIK---RDQQKIKEIQLK-TGQEEGLKPKAEDLDACNLKRRKGSFG 939

  Fly   760 QRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKEL---ERLILEREDLSR 821
                        ::|.......:.:|  |...:......||.:.:||.:|   |.::.::|.|.:
Human   940 ------------SIDHLQKLDEQKKW--LDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQ 990

  Fly   822 ELNIMENGQTADRQTDEFNEVDNLK--TNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLL 884
            |.:.:||.:.  |.:...| .|:||  |.::.:::.:.                :.:|....|..
Human   991 EKSHLENKKL--RSSQALN-TDSLKISTRLNLLEQELS----------------EKNVQLQTSTA 1036

  Fly   885 DEVSTVAEAKFILQKFSDTAIVMSCN----------LAIAESH----LQEKESLLK---EVKQES 932
            :|.:.::|...:|||..|.......|          |:..|.|    |:|....|:   |.:.||
Human  1037 EEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNES 1101

  Fly   933 GIQQQILQHFLSQNSNVHIADIFDSLNLKGSNI---ASSVNPGSQKSLI---SNATYDIPQDDKN 991
                       .||....:...|.:|:...:|:   .:.::|...::::   .|...::.:.::.
Human  1102 -----------IQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERK 1155

  Fly   992 SEFHQVEMR 1000
            .:.:..||:
Human  1156 QQLYNEEMK 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	170/350 (49%)
		KISc	13..370	CDD:214526	173/392 (44%)
		KASH_CCD	409..589	CDD:291334	54/354 (15%)
		RasGAP	<685..750	CDD:295371	15/64 (23%)
KIF27	XP_011517150.1	KISc_KIF4	4..342	CDD:276823	170/350 (49%)
		KISc	5..348	CDD:214526	173/356 (49%)
		COG1340	820..1077	CDD:224259	60/301 (20%)
		DUF4200	826..>910	CDD:290574	17/94 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820