Protein Alignment Klp31E and cmet

DIOPT Version :9

• Sequence 1: NP_001162935.1
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1179
• Identity: 282/1179 - (23%)
• Similarity: 497/1179 - (42%)
• Gaps: 277/1179 - (23%)

  Fly     7 SINKDSSVRVAVRIRP-------------QNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYV 58
            |....||::|.:::||             :.|..|.|        :..||         :.||||
  Fly     2 SAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLAD--------SHAEP---------YVFDYV 49

  Fly    59 FDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPR 123
            ||..::..:::....:.:|.:.:.|:|.|:.|||||.|||||||         ..|....|::..
  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---------MGDEQNPGVMVL 105

  Fly   124 AVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQ 188
            |.:.||..|     ||.:|.       .|.|.|.|||:|||.|:|||:  .||.:.||||..:|.
  Fly   106 AAKEIFQQI-----SSETER-------DFLLRVGYIEIYNEKIYDLLN--KKNQDLKIHESGNGI 156

  Fly   189 ITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDN 253
            :.::.... .|....|.|:.|..|...||...|.||::||||||:|.|.:..::    ||:..|:
  Fly   157 VNVNCEEC-IITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRK----SDHSDDD 216

  Fly   254 DLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDS 318
              ..:.|..:.||||||||..:|.|.|.|.:||..||..||.|.|.|.:|.:.:.... ..||||
  Fly   217 --AVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRF-TNYRDS 278

  Fly   319 KLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRT-ISQLR 382
            ||||:||.|||||:.|.:|..:.||..:  |:.:||.:|.||:.|:.|.::|:..|..| :.:|.
  Fly   279 KLTRILQASLGGNAFTSIICTIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLE 341

  Fly   383 REIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIA---TLTQR 444
            |||..|:.:|.|                .:..|||:   .:::.|::::|.....|.   :|:.:
  Fly   342 REIKVLKDKLAE----------------EERKNENQ---QKVEHLERQIKHDMHKIICGHSLSDK 387

  Fly   445 NADLKTNLDLNKW-TSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKP 508
            ....:.    ..| .:...|.:|:|:.                .:.|.|.....|.:..|   ||
  Fly   388 GQQKRR----RTWCPTASGSHLELAET----------------GTTEDRIDQFPKVSHLP---KP 429

  Fly   509 V-YDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSE--ETEVASSDSEAEEVVKDLEAID--- 567
            | :.:....|...::.:...:|.|..: |.::.::|.|  ..|.....|...:|:|.:..|.
  Fly   430 VFFHTSNAGKRWDNIPKTINILGSLDI-GTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493

  Fly   568 -------------------NDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIEN------ 607
                               .|::|.|.|.:..|:.....:.::    |||:.:..:.:|
  Fly   494 DLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLK----EKLAEVTAQRDNLEQESL 554

  Fly   608 TQKERDDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSH--- 669
            .:|||.|.|....||:...::.:..|: ::.|.|:|.::..:|.::...:..:..:.:.::|
  Fly   555 AEKERYDALEKEVTSLRADNEAANSKI-SELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKS 618

  Fly   670 ---------------EVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQEE------SRKSKEIA 713
                           |..|.:|:..|:.|....::..|:....|...:||:      ..|.:|:.
  Fly   619 SKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELE 683

  Fly   714 QLLKEQRRQKNA---------VLTLEAKVSAKEQILKRKTEEVI-----ALRKSQRGKSGQRAPA 764
            :|:.:...:||:         ::::..|:.:.|......:.|:|     ..|.|:...:.|.|..
  Fly   684 KLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFG 748

  Fly   765 HLTSKIATLD--------GFSTRSARHRWENLYRNILHAARNRQLITQLEKELERL-ILEREDLS 820
            .|..:...||        |.:|...:|.         |.....|   :|::|.|:| ...|...|
  Fly   749 QLQERYDALDQQWQAQQAGITTLHEKHE---------HVQEKYQ---KLQEEYEQLESRARSASS 801

  Fly   821 RELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLD 885
            .|...::|..|            ..:.:|:.:.|.:|..|..:.|.::::.||:    |::....
  Fly   802 AEFQRLQNDNT------------KFQADIASLNERLEEAQNMLTEVQNSESTVE----KLRIQNH 850

  Fly   886 EVSTVAEAKFILQKFSDTAIVMSC-NLAIAESHLQEKESLLKEVKQ-----------ESGI---- 934
            |::  |:.|.:...|.:......| :..:.|| :||.::|.:|:||           .|||
  Fly   851 ELT--AKIKELETNFEEMQREYDCLSNQLMES-VQENDALREEIKQRPTSHVEESMRSSGISSDF 912

  Fly   935 --QQQ---ILQHFLSQNSNVH---------IADIFDSLNLKGSNIASSVNPGSQKSLISNATYDI 985
              |:|   :|..|:..:.:|.         |:.:|.:..:|    .....|| .|..:.:|.| |
  Fly   913 DEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMK----LDQSEPG-LKLCLESAEY-I 971

  Fly   986 PQDDKNSEF------------HQVEMRRTTSRSPSPLGNSDPFDKSPKVRRRTAKRQDLLFGDTE 1038
            .:|::.|:.            |:.:::|.:.............|...::.:...::..|:    |
  Fly   972 EEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALM----E 1032

  Fly  1039 LSEQTFNKM 1047
            .:|.|.|:|
  Fly  1033 ATEATINEM 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	130/364 (36%)
		KISc	13..370	CDD:214526	131/369 (36%)
		KASH_CCD	409..589	CDD:291334	34/208 (16%)
		RasGAP	<685..750	CDD:295371	13/84 (15%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/369 (36%)
		Motor_domain	8..321	CDD:277568	129/362 (36%)
		Smc	<680..1449	CDD:224117	78/403 (19%)
		TMPIT	779..>867	CDD:285135	22/108 (20%)
		Smc	1042..1910	CDD:224117	282/1179 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840