Protein Alignment Klp31E and cmet

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1179
• Identity: 282/1179 - (23%)
• Similarity: 497/1179 - (42%)
• Gaps: 277/1179 - (23%)

  Fly     7 SINKDSSVRVAVRIRP-------------QNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYV 58
            |....||::|.:::||             :.|..|.|        :..||         :.||||
  Fly     2 SAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLAD--------SHAEP---------YVFDYV 49

  Fly    59 FDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPR 123
            ||..::..:::....:.:|.:.:.|:|.|:.|||||.|||||||         ..|....|::..
  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---------MGDEQNPGVMVL 105

  Fly   124 AVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQ 188
            |.:.||..|     ||.:|.       .|.|.|.|||:|||.|:|||:  .||.:.||||..:|.
  Fly   106 AAKEIFQQI-----SSETER-------DFLLRVGYIEIYNEKIYDLLN--KKNQDLKIHESGNGI 156

  Fly   189 ITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDN 253
            :.::.... .|....|.|:.|..|...||...|.||::||||||:|.|.:..::    ||:..|:
  Fly   157 VNVNCEEC-IITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRK----SDHSDDD 216

  Fly   254 DLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDS 318
              ..:.|..:.||||||||..:|.|.|.|.:||..||..||.|.|.|.:|.:.:.... ..||||
  Fly   217 --AVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRF-TNYRDS 278

  Fly   319 KLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRT-ISQLR 382
            ||||:||.|||||:.|.:|..:.||..:  |:.:||.:|.||:.|:.|.::|:..|..| :.:|.
  Fly   279 KLTRILQASLGGNAFTSIICTIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLE 341

  Fly   383 REIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIA---TLTQR 444
            |||..|:.:|.|                .:..|||:   .:::.|::::|.....|.   :|:.:
  Fly   342 REIKVLKDKLAE----------------EERKNENQ---QKVEHLERQIKHDMHKIICGHSLSDK 387

  Fly   445 NADLKTNLDLNKW-TSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKP 508
            ....:.    ..| .:...|.:|:|:.                .:.|.|.....|.:..|   ||
  Fly   388 GQQKRR----RTWCPTASGSHLELAET----------------GTTEDRIDQFPKVSHLP---KP 429

  Fly   509 V-YDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSE--ETEVASSDSEAEEVVKDLEAID--- 567
            | :.:....|...::.:...:|.|..: |.::.::|.|  ..|.....|...:|:|.:..|.
  Fly   430 VFFHTSNAGKRWDNIPKTINILGSLDI-GTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493

  Fly   568 -------------------NDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIEN------ 607
                               .|::|.|.|.:..|:.....:.::    |||:.:..:.:|
  Fly   494 DLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLK----EKLAEVTAQRDNLEQESL 554

  Fly   608 TQKERDDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSH--- 669
            .:|||.|.|....||:...::.:..|: ::.|.|:|.::..:|.::...:..:..:.:.::|
  Fly   555 AEKERYDALEKEVTSLRADNEAANSKI-SELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKS 618

  Fly   670 ---------------EVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQEE------SRKSKEIA 713
                           |..|.:|:..|:.|....::..|:....|...:||:      ..|.:|:.
  Fly   619 SKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELE 683

  Fly   714 QLLKEQRRQKNA---------VLTLEAKVSAKEQILKRKTEEVI-----ALRKSQRGKSGQRAPA 764
            :|:.:...:||:         ::::..|:.:.|......:.|:|     ..|.|:...:.|.|..
  Fly   684 KLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFG 748

  Fly   765 HLTSKIATLD--------GFSTRSARHRWENLYRNILHAARNRQLITQLEKELERL-ILEREDLS 820
            .|..:...||        |.:|...:|.         |.....|   :|::|.|:| ...|...|
  Fly   749 QLQERYDALDQQWQAQQAGITTLHEKHE---------HVQEKYQ---KLQEEYEQLESRARSASS 801

  Fly   821 RELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLD 885
            .|...::|..|            ..:.:|:.:.|.:|..|..:.|.::::.||:    |::....
  Fly   802 AEFQRLQNDNT------------KFQADIASLNERLEEAQNMLTEVQNSESTVE----KLRIQNH 850

  Fly   886 EVSTVAEAKFILQKFSDTAIVMSC-NLAIAESHLQEKESLLKEVKQ-----------ESGI---- 934
            |::  |:.|.:...|.:......| :..:.|| :||.::|.:|:||           .|||
  Fly   851 ELT--AKIKELETNFEEMQREYDCLSNQLMES-VQENDALREEIKQRPTSHVEESMRSSGISSDF 912

  Fly   935 --QQQ---ILQHFLSQNSNVH---------IADIFDSLNLKGSNIASSVNPGSQKSLISNATYDI 985
              |:|   :|..|:..:.:|.         |:.:|.:..:|    .....|| .|..:.:|.| |
  Fly   913 DEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMK----LDQSEPG-LKLCLESAEY-I 971

  Fly   986 PQDDKNSEF------------HQVEMRRTTSRSPSPLGNSDPFDKSPKVRRRTAKRQDLLFGDTE 1038
            .:|::.|:.            |:.:::|.:.............|...::.:...::..|:    |
  Fly   972 EEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALM----E 1032

  Fly  1039 LSEQTFNKM 1047
            .:|.|.|:|
  Fly  1033 ATEATINEM 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	130/364 (36%)
		Mplasa_alph_rch	<372..>748	CDD:275316	77/444 (17%)
		SMC_prok_B	622..>899	CDD:274008	57/323 (18%)
		Rcc_KIF21	798..870	CDD:410202	15/72 (21%)
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	129/362 (36%)
		SMC_prok_B	539..1431	CDD:274008	103/545 (19%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752