DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and Klp54D

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	201/762 - (26%)
Similarity:	313/762 - (41%)	Gaps:	199/762 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSSVRVAVRIRPQNSRELIDMCRICTTVTL-GEPQIFL-GSD------------KAFTFDYVFDT 61
            :.::.|.||:||.|.:|..|  |..:|:.. |..|:.| |:|            :.||::.||:.
  Fly   164 EDNINVVVRVRPLNDKEKRD--RHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTYNVVFEP 226

  Fly    62 NSNQCDI--YSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTG----FDHESESSDSVQLGI 120
            .:.|.||  ||. ::::::..:.|::.|...|||||||||:|: ||    |..:....|. :.|:
  Fly   227 GATQEDILDYSG-IKRIIEMGIEGFSCTAFCYGQTGSGKTHTL-TGPPDLFVGKPNPKDP-RHGL 288

  Fly   121 IPRAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIH-ED 184
            |.|:..::|..|:..:            ...:.|...::|:|||.:.|||:|.:......:. ..
  Fly   289 IFRSFLYLFQLIKNRK------------DVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSK 341

  Fly   185 ASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDN 249
            .||...:.........:..|.|..|::|...|...|..|||.|||||.:.|:.:.       ||.
  Fly   342 KSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHIL-------SDQ 399

  Fly   250 VPDNDL-ETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHV 313
            ..|..: .:...|.:||||||||..|:|.:.|:...|..:||..|:.||.|||:|.|..||..|:
  Fly   400 QTDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHI 464

  Fly   314 PYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTI 378
            |||||:||:||.|||.||..|||||||||:..:..||||||:||:||:.|:.|..|..|.....|
  Fly   465 PYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALI 529

  Fly   379 SQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQ 443
            ..|:|:|.|||:|
  Fly   530 LSLKRDIHALQME---------------------------------------------------- 542

  Fly   444 RNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKP 508
             |..||..|:|:...:.:...||          .:.|||...:.|               ....|
  Fly   543 -NDHLKAALNLHHQAAPNGGPVE----------NLLELQLDRVSS---------------GGGVP 581

  Fly   509 VYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMR 573
            |        .|.||:|..||                       ..||..|:|| |..::|
  Fly   582 V--------PKVDLQRLPEL-----------------------DGSELAELVK-LYMVEN----- 609

  Fly   574 TKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTDY 638
                |.|...|:....:|........::..:.|...|:.:||......|...|::.::... |..
  Fly   610 ----ESLRQENNHLFTVRETILRDQEIVCRENERLLKKLEDVNKVCVRSPLIPARPAISPT-TGK 669

  Fly   639 ESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQ 703
            |:..:.:.|....||:.....:..:|                            :||:.:||...
  Fly   670 ETPGTEIWTNPEPLQSPPGPDLPIEQ----------------------------RMSENANRRTD 706

  Fly   704 EESRK--SKEIAQ---LLKEQRRQKNAVLTLEAKVSAKEQILKRKTE 745
            ...::  .|.||:   ::....|:.::.:|.|..::.:|...|:.||
  Fly   707 TAQKRIDQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAKQSTE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	133/373 (36%)
		KISc	13..370	CDD:214526	135/378 (36%)
		KASH_CCD	409..589	CDD:291334	29/179 (16%)
		RasGAP	<685..750	CDD:295371	14/66 (21%)
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	135/377 (36%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	132/369 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940