Protein Alignment Klp31E and kif4a

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_001006741.1
• Gene: kif4a / 448410
• XenbaseID: XB-GENE-5932310
• Length: 1231
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 339/1150 - (29%)
• Similarity: 557/1150 - (48%)
• Gaps: 208/1150 - (18%)

  Fly     8 INKDSS--VRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYS 70
            :.||..  ||||:|.||...:||.:.|:.|.|...||||:.:|::|:||:|||||.::.|.::|:
 Frog     1 MGKDEGIPVRVALRCRPLVPKELNEGCKTCLTFVPGEPQVIVGTEKSFTYDYVFDPSTEQEEVYN 65

  Fly    71 DCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQL 135
            ..|..|:.....||||||||||||||||||:||..:.|:.|:..:|  |:|||.|:.:|..|||
 Frog    66 SAVGPLIKGLFKGYNATVLAYGQTGSGKTYSMGGAYTHDQENEPTV--GVIPRVVKALFREIEQ- 127

  Fly   136 EGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSN-FKIHEDASGQITISGASIKPI 199
                .||.       :|.|.|.|:|:|||:|.|||......:| ..|.||....|.|.|.:.:.:
 Frog   128 ----RSEW-------EFHLKVSYLEIYNEEILDLLYAARDKTNAISIREDPKEGIKICGLTERDV 181

  Fly   200 YQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDL-ETLTSKFH 263
            ....|.:..|:||..:||.|||.||.|||||||:|||.:         |...:.|. .:..||.|
 Frog   182 KTALDTVSCLEQGNSSRTVASTAMNSQSSRSHAIFTISI---------DQRKEGDKNNSFRSKLH 237

  Fly   264 FVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSL 328
            .||||||||.|:|:|.|:|.:||||||.|||.|||.||||||::|:...||||||||||||||||
 Frog   238 LVDLAGSERQKKTKAEGDRLKEGISINRGLLCLGNVISALGDENKKGSFVPYRDSKLTRLLQDSL 302

  Fly   329 GGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELL 393
            ||||.|||||||||:|.:..||||||:||:|||.||||..:|.|..:..:.:|::::..||:.||
 Frog   303 GGNSHTLMIACVSPADSNMEETLNTLRYADRARKIKNKPIVNTDPQAAELQRLKQQVQELQVLLL 367

  Fly   394 EYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRNADLKTNLDLNKWT 458
            :...|.|.|                            |.|::.        :.:|::.|:.||..
 Frog   368 QAHGGTLPV----------------------------LNSMEP--------SDNLQSLLERNKNL 396

  Fly   459 SDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLE 523
            .::|.  ::::.:.:..::..:...|:|.:|:..:::..|.....::|          ..|.||:
 Frog   397 EEENG--KLSRELSEAAVQTAQFLEKIILTEQQNEKLASKIEELKQHA----------ACKVDLQ 449

  Fly   524 RERELLMSRSLP---GI---------QNQNVSS-------EETEVASSDSEAEE----------- 558
            |..|.|..:.|.   |:         |.|:.||       ..|||.:|..|:||
 Frog   450 RLVETLEDQELKENVGVILDLQQVIMQLQDESSGIAASIEAMTEVVASSPESEEPRDSGEKRSSD 514

  Fly   559 ------------VVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKE 611
                        :.|:|..::..:.::..|..::...:|:.|.:::.|...:..|..::...|||
 Frog   515 AFTTDHALRQAQLSKELIELNKALLLKEALARKMAQNDSQLEPIQSEYLNNIKQLESEVGALQKE 579

  Fly   612 RDDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTL 676
            ::|::..:.::....::..|.:.:.....::....||::|....|.:.::.::   |.|..:..|
 Frog   580 KEDLIMALHSAKKDTNQAKLSERRRKRLQELEGQMTELKKKLGEQSKLLKLRE---STEKTVTKL 641

  Fly   677 RNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILK 741
            .:|:..:|..:|:||::|.:.:.:.:..:.:|:||:.||.::.|:::..:|.||.....:..:|:
 Frog   642 NHEIQGMKVQRVQLMRQMKEDAEKFRTWKQQKTKEVIQLKEKDRKRQYELLKLERDFQKQANVLR 706

  Fly   742 RKTEEVIALRK-------------------SQRGKSG--QRAPAHLTSKIATLDGFSTRSARHRW 785
            |||||.....|                   ..||..|  .|..:.|.:::..|  .||..|:...
 Frog   707 RKTEEAATANKRLKEALLRQKEAMEKRKDSQNRGMEGAASRVKSWLANEVEVL--VSTEEAQRHL 769

  Fly   786 ENLY--RNILHAARNRQLITQLEKEL---ERL---ILEREDLSRELNIMENGQTADRQTDEFNEV 842
            .:|.  |.||     .|.|.||:::.   ||:   :..|.....||..||...:..:|      :
 Frog   770 NDLLEDRKIL-----AQDIAQLKQKKDAGERIPTKMRRRTYTVAELENMEEESSVTKQ------I 823

  Fly   843 DNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDE-------VSTVAEAKFILQKF 900
            ::|:|.:......|..:||.:::.:..::.|:.....|.::::.       ::.:..:|..:.|.
 Frog   824 ESLETEMELRSAQIADLQQKLLDADAEEEMVKRRWETITNIMEAKCALKYLITELVSSKVAVSKL 888

  Fly   901 SDTAIVMSCNLAIAESHLQEKESLLKEVKQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNI 965
            ..:......::|..:..:.|:.:.:.|::.|.  |.|::|  |.|.....|..:...|..|.:.:
 Frog   889 ESSVKQNRAHIADLQKTIFEERNQMAEMETEH--QSQLMQ--LEQQHQEKILYLLSQLQQKQAPV 949

  Fly   966 ASSVN--PGSQ-----KSLISNATYDIPQDDKNSE---------------------FHQVEMRRT 1002
            ...|.  |..|     |.|:....:...:.:|..|                     .|....::.
 Frog   950 PVQVEEPPAEQMTEREKQLMERLRFQDEEIEKMKELCEKNQQLLQENDMYKQKLALLHVASGKKL 1014

  Fly  1003 TSRSPSPLGNS--DPFD---KSPKVRRRT-AKRQDLLFGDTELSE 1041
            .:..|:.:.||  .|||   ..|:.:||| ||...::..|. |||
 Frog  1015 HNILPTAVLNSPDSPFDFVPPKPRGKRRTNAKAAAVILEDL-LSE 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	181/355 (51%)
		Mplasa_alph_rch	<372..>748	CDD:275316	80/417 (19%)
		SMC_prok_B	622..>899	CDD:274008	63/312 (20%)
		Rcc_KIF21	798..870	CDD:410202	17/77 (22%)
kif4a	NP_001006741.1	KISc_KIF4	7..338	CDD:276823	181/353 (51%)
		PTZ00121	<432..1003	CDD:173412	115/600 (19%)