DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and Kif3C

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	224/731 - (30%)
Similarity:	334/731 - (45%)	Gaps:	182/731 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SVRVAVRIRPQNSRE-------LIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYS 70
            :::|.||.||.|..|       ::::.....:||  .|...:...|.|.||.|::..::...||.
  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVT--NPSARISQQKKFIFDSVYNMKTDTEVIYD 66

  Fly    71 DCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQL 135
            :....||:||:.|||.|:.||||||.|||:||      :.:.:.|...||||:...|||..|
  Fly    67 EMCYSLVESTIEGYNGTIFAYGQTGCGKTHTM------QGDENFSNSTGIIPKCFDHIFERI--- 122

  Fly   136 EGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASI---- 196
              |.|:       :.::...|.|:|:|||.|.|||   |||.|..:......::...|.|:
  Fly   123 --SMTT-------NVRYLALVTYLEIYNERIRDLL---NKNENTNVINHFLKELPGIGVSVPTLT 175

  Fly   197 -KPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDL--ETL 258
             :|:...:....:|..|...|.||:|.||..|||||.:|||.:.:    :|..|...:|.  ...
  Fly   176 TQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQ----SPFLNSIGSDAFGGIC 236

  Fly   259 TSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRL 323
            ..|...||||||||.::|.|.|:|.:|...||..|.||||.||:|.|  .:|.|||:||||||||
  Fly   237 RGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKAKHVPFRDSKLTRL 299

  Fly   324 LQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAAL 388
            ||||||||::||||:|:||:|..:.||::||:||:||:||.||.|||:|.....:.|.:.||..|
  Fly   300 LQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYL 364

  Fly   389 QLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQ-RLKSLQSTIATLTQRN--ADLKT 450
            :..|.|.:|           .|:...:.||::.|.:|.:|. .:.|.::.......||  |..||
  Fly   365 KRMLQESQQ-----------IINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKT 418

  Fly   451 NLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTK----LIESEEHRKQMEIKATTSPRNAKPVYD 511
            |          ||                 :.||    ||:|:|   :::::|
  Fly   419 N----------NS-----------------ILTKPNFPLIQSKE---EVQLQA------------ 441

  Fly   512 SDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMRTKL 576
                        |.|..|:.|||.|                   .|.:        :|.|::.|.
  Fly   442 ------------RSRIDLIKRSLIG-------------------GERI--------HDFELKEKH 467

  Fly   577 IEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVL----ANMTTSVSTPSKDSLKKVKTD 637
            :.:      :|...|     .||.:...:...:.|..|:|    |.:|..:.         :|.|
  Fly   468 MAR------KYAAQR-----HLSAIAIALSRVKCEDRDLLQGHYATITQEID---------IKND 512

  Fly   638 Y----ESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQS 698
            |    :.||..::.|:..|        .|:.|| ..|..:..:||...::||.: :|..|.|  |
  Fly   513 YIRKCKEKIKMLEMEVSDL--------NSEFQL-DREDYLDEIRNLGRQVKFHQ-QLFLKFS--S 565

  Fly   699 NRHKQEESRKSKEIAQ 714
            |..|.:.:.....|.|
  Fly   566 NPGKFDRNWTPDTILQ 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	145/364 (40%)
		KISc	13..370	CDD:214526	149/370 (40%)
		KASH_CCD	409..589	CDD:291334	34/186 (18%)
		RasGAP	<685..750	CDD:295371	9/30 (30%)
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	144/363 (40%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	142/357 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940