Protein Alignment Klp31E and Klp98A

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1231
• Identity: 319/1231 - (25%)
• Similarity: 498/1231 - (40%)
• Gaps: 403/1231 - (32%)

  Fly    12 SSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFL--------------------GSDK--AFT 54
            ||::||||:||.|||| |||          :.|:.:                    |.|.  .||
  Fly     2 SSLKVAVRVRPFNSRE-IDM----------DAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFT 55

  Fly    55 FDY---VFDTN----SNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYT-MGTGFDHESE 111
            |||   .||..    :.|..:|||....:||....||||.|.||||||||||:| |||..:.
  Fly    56 FDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNP--- 117

  Fly   112 SSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKN 176
                   |:|||....:|:.:...:.|.|.          :.....|:|:|||.:.|||...:..
  Fly   118 -------GLIPRICEELFARMRVGQESGTG----------YRTHASYLEIYNERVKDLLAAQSTG 165

  Fly   177 SNFKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTI-FVRR 240
            ...::.|..|....:...|...:....:..:.:.:|...||||||.|||.||||||:||| ||:.
  Fly   166 HGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA 230

  Fly   241 QRLLTPSDNVPDNDLETLT-SKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALG 304
                     |..||:.:.| ||.|.||||||||...|.|||:|.:||..||..|:.||:.||||.
  Fly   231 ---------VFMNDMPSETVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALA 286

  Fly   305 DK-------------------SKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMET 350
            ::                   |||.|::|||||.||.||:|||||||:|:|||.:||:|.::.||
  Fly   287 EQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSET 351

  Fly   351 LNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFN 415
            |:||:|||||:||.||..:|:|.:.:.|.:||.||..|:
  Fly   352 LSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLK-------------------------- 390

  Fly   416 ENKLLLSEIKRLQQRLKSLQSTIATLTQRNADLKTNLDLNKWT----------SDDNS------- 463
              .:|..:|..||..||    .:|.|.::.|..|...:  :||          .:..|
  Fly   391 --SMLAGDIHSLQPSLK----VLADLQKKEAQEKVLTE--EWTEKWKVAQSILQEQKSLGLRKSG 447

  Fly   464 -----DVEIAKVVGQY--------MLEIEELQTKLIESEEHRKQMEIK----------------- 498
                 |.|:..::|.:        :..::|.:|: |.||:.....:|:
  Fly   448 VGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETR-IGSEDADVAQDIELAGDGIRAQHCSIFLKG 511

  Fly   499 --ATTSP-------RNA------KPVYDSDII----------------TKAKKDLERERELLMSR 532
              .|..|       .||      |.:...|||                .|.:|||.|. :|.|||
  Fly   512 GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRS-QLDMSR 575

  Fly   533 -SLPGIQNQNV------SSE---------------ETEVASSDSE-AEEVVKDLEAIDNDIEMRT 574
             ||.....:|:      |.|               :..::..|.| .:|..|.|:.|:|.::...
  Fly   576 LSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLN 640

  Fly   575 KLIEQLELTNSRY---------EQMRTHYEEK--LSVLYCKIE-------------NTQKERDDV 615
              :|:::: :.:|         |.:|...||.  |.:|.|:.:             |.:|.:.|:
  Fly   641 --VERVQM-HDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDI 702

  Fly   616 LANMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNEL 680
            :....::..| ..||.|:..::|.:|      |:::||:.      .|......::..||..|:
  Fly   703 VCRQISAFQT-QLDSKKRDFSEYVAK------ELQELQDC------GKLDEMGMKIEEGTPLND- 753

  Fly   681 NELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQ-RRQKNAVLTLEAKVSAKEQILKRKT 744
                    :|:.::|...:..          .||.:|:. ||....:..|:.:::.||:||...
  Fly   754 --------ELLLQVSDSLDLF----------AAQFIKDTVRRNNEEIRKLDEQIAEKERILNAS- 799

  Fly   745 EEVIALRKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKEL 809
                                  |:|||.:|                         :.:.:::.:|
  Fly   800 ----------------------TTKIAKVD-------------------------ETMLEIQAQL 817

  Fly   810 ERLILEREDLSRELNIM---------ENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQAIME 865
            |||.|||.:...|...|         :.|..:...:...||.|::..:.:|             |
  Fly   818 ERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTY-------------E 869

  Fly   866 FEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHLQE--KESLLKEV 928
            ..||..|.||:::.:.|     .|:.|.:      .......||:   ||...::  |:.|
  Fly   870 TCDTFHTAQSNLSLVSS-----PTITEGQ------QSPLSNCSCD---AEDEAEDTRKDDL---- 916

  Fly   929 KQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLISNATYDIPQDDKNSE 993
               ||..::..:...:..|:   .....|:.:.||..|.|..|.|| :::|::  .:..|.:|..
  Fly   917 ---SGSSEETSRTCTAGPSS---GSGSGSVGIGGSGSAPSCTPSSQ-AIMSDS--GVCLDSRNQA 972

  Fly   994 FHQ------------VEMRRTTSRSPSPLG-NSD---PFDKSPKVRRRTAKRQDLLFGDTE 1038
            ..|            .....|.|.|...|| :||   |:.....:||:.|.::.|:..:.|
  Fly   973 ILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMKNLE 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	158/402 (39%)
		Mplasa_alph_rch	<372..>748	CDD:275316	95/501 (19%)
		SMC_prok_B	622..>899	CDD:274008	53/286 (19%)
		Rcc_KIF21	798..870	CDD:410202	16/80 (20%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	161/408 (39%)
		Kinesin_assoc	370..478	CDD:465047	24/141 (17%)
		FHA_KIF16	449..556	CDD:438760	17/107 (16%)
		SMC_N	624..>864	CDD:481474	60/322 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784