Protein Alignment Klp31E and kif4

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_957117.1
• Gene: kif4 / 393796
• ZFINID: ZDB-GENE-040426-1545
• Length: 1248
• Species: Danio rerio
• Alignment Length: 1095
• Identity: 329/1095 - (30%)
• Similarity: 538/1095 - (49%)
• Gaps: 163/1095 - (14%)

  Fly    14 VRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEKLVD 78
            ||||:|.||...:|:.:.|:.|......|||:.:|:|||||||||||..:.|.::::..|..|:.
Zfish    11 VRVALRCRPLVPKEINEGCQCCLNFVPSEPQVIVGNDKAFTFDYVFDPTTEQEEVFNTAVSPLLS 75

  Fly    79 STLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEH 143
            ....||:||||||||||||||::||..:..|.|:..:|  |:|||.:|.||            :.
Zfish    76 GLFKGYHATVLAYGQTGSGKTFSMGGTYTSEQENEPTV--GVIPRVIRRIF------------QE 126

  Fly   144 PAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQPHDALKY 208
            .|.....:|.|||.|:|:|||:|.|||..........|.||....|.|.|.:.:.:...|:.:..
Zfish   127 KAKRTDCEFVLAVSYLEIYNEEILDLLCTSKDKPVISIREDPKDGIKIVGLTERDVLNAHEMVCC 191

  Fly   209 LQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFVDLAGSERL 273
            |:.|..|||..||.||..||||||:|||.:.::|      |....|:  :.||.|.||||||||.
Zfish   192 LEMGNSARTVGSTAMNAASSRSHAIFTISLEQRR------NGDKTDV--MVSKLHLVDLAGSERQ 248

  Fly   274 KRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIA 338
            |:|:|.|:|.:||||||.|||:|||.||||||:||:...||||||||||||||||||||.|||||
Zfish   249 KKTKAEGDRLKEGISINRGLLSLGNVISALGDESKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIA 313

  Fly   339 CVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQG--KLI 401
            ||||:|.:..||:|||:||:|||.||||..:|.|..:..:.:|::::..||:.||..:.|  .::
Zfish   314 CVSPADSNIEETINTLRYADRARKIKNKPVLNVDPRAAEMKRLKQQVQELQVMLLHARGGVAPVL 378

  Fly   402 VDCEGNTTISDTFNENKLLLSEIKRLQQRL-KSLQSTIA------TLTQRNADLKTNLD-LNKWT 458
            ...|....:|....:|:.|..:..:|.:.| :|:..|.|      .:.|.|..|::.|| |.:..
Zfish   379 SGSEPAENVSKVLEQNRSLQDQNSKLSRELSESVGQTAAMFERMLMMEQTNEKLQSKLDELRQHA 443

  Fly   459 SDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLE 523
            :   ..|::.::|            :.:|.:|.|:.:|:     .:|.:.:.           ||
Zfish   444 A---CKVDLQRLV------------ETLEDQELRENVEV-----IQNLQQII-----------LE 477

  Fly   524 RERELL-MSRSLPGIQNQNVSSEETEVASSDSEA------------------------------- 556
            .:||.. ::.::..|.:.|.||.|.....|.|.|
Zfish   478 LQRESAGIAATIDAITSGNASSLEAAAHCSPSTAGAQAEICPGQDGAVPEAKDSPEAYTAQHALR 542

  Fly   557 -EEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMT 620
             .::.|:|..::..:.::...::::...:|..|.|:|.|:|.:..|...:.:.|||::|::..:.
Zfish   543 QAQMSKELIELNKVLALKEAFVKKMCQNDSHLEPMQTQYQESIQSLQAAVGSLQKEKEDLVQTLQ 607

  Fly   621 TSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVR-IGTLRNELNELK 684
            ::....::..|.:.:.....::....||::|....|.:.::    ||...|| :..|..|:..:|
Zfish   608 SAKKDTNQAKLSEQRRKRLQELEGQMTELKKKLQDQSKLLK----LKESSVRNVAKLNQEIQAMK 668

  Fly   685 FAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIA 749
            ..:|:||::|...|.:.:..:.:|.||:.||.::.|:::..:|.||.....:..:|:|||||..|
Zfish   669 SQRVQLMRQMKDDSEKFRLWKQKKDKEVLQLKEKDRKRQYEMLKLERDFQKQASVLRRKTEEAAA 733

  Fly   750 LRKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKELERLIL 814
            ..|  |.|...:..:.:..|...:......|..:|.:|...|.:....:.:   :..:.|:.|:.
Zfish   734 ANK--RLKDALQKRSEVAEKRKDVQNRGAESVTNRVKNWLLNEIEVLVSTE---EARRHLQDLLE 793

  Fly   815 EREDLSRELN----IMENGQ----TADRQTDEFNE--------------VDNLKTNISYIQENIE 857
            :|:.|:.|::    .||.|:    ...|:|...:|              |::|.|.::.....|.
Zfish   794 DRKMLAEEISQLRQQMEAGEKPVSKVRRRTLTISELEGKCELEASISKQVESLDTEMALRSAQIA 858

  Fly   858 HVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNL-AIAESHL-QE 920
            .:||.:::.::.        .:::...|.::|:.|||..| |.....:|.|..| |..||.| ||
Zfish   859 DLQQKVLDADNE--------GRMKQRWDSITTIIEAKSAL-KILMAEVVASKTLNAKQESELQQE 914

  Fly   921 KESLL-------KEVKQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLI 978
            |.:||       .|.|..|.:..:...|.:..... |...:   |.|.|......|....|:.|:
Zfish   915 KANLLDMQKVLCDERKLMSAMDMEHQSHLVEMEQR-HQEKV---LYLLGQLQNKPVALEEQQELV 975

  Fly   979 SNATYDIPQDDKNSEFHQVEMRRTTSRSPSPLGNSDPFDKSPKVRRRTAKRQDLL 1033
            |....::.|   ..:|.:.|:.:....|          |::.|::....:.:..|
Zfish   976 SKREQELLQ---RLQFQEEEIEKLRELS----------DQNQKLKEENEQYKQKL 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	174/349 (50%)
		Mplasa_alph_rch	<372..>748	CDD:275316	86/419 (21%)
		SMC_prok_B	622..>899	CDD:274008	64/299 (21%)
		Rcc_KIF21	798..870	CDD:410202	17/93 (18%)
kif4	NP_957117.1	KISc_KIF4	9..339	CDD:276823	174/349 (50%)
		SMC_prok_B	<420..794	CDD:274008	81/413 (20%)
		SMC_prok_B	<621..998	CDD:274008	91/401 (23%)
		DUF3435	<938..1082	CDD:371796	16/97 (16%)