DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and Klp59C

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	152/547 - (27%)
Similarity:	227/547 - (41%)	Gaps:	129/547 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VRVAVRIRPQNSRELIDMCRICT------TVTLGEPQIFLG-----SDKAFTFDYVFDTNSNQCD 67
            :.|.||.||...:||.|..:...      |:.:.||:..:.     .:.:|.||||||...:...
  Fly   188 IMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNAT 252

  Fly    68 IYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGI 132
            :|......|:.....|..||..||||||||||||||..|....:||..   ||...|.:.:||.:
  Fly   253 VYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMD---GIYAMAAKDVFSTL 314

  Fly   133 EQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIK 197
            :.:..:..:          ..:...:.|:|...:||||.|  .....::.||.:.|:.:.|.:..
  Fly   315 KTVPYNKLN----------LKVYCSFFEIYGTRVFDLLMP--GKPQLRVLEDRNQQVQVVGLTQN 367

  Fly   198 PIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKF 262
            |:....:.|..|:.|...||:..|..|.:||||||:|.|.:|...            .|.|..||
  Fly   368 PVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAA------------GEKLHGKF 420

  Fly   263 HFVDLAGSERLKRTQATGERAR-EGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQD 326
            ..:||||:||.....:...:.| ||..||..||.|..||.|||.:|.   |:|:|.||||::|:|
  Fly   421 SLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSS---HLPFRGSKLTQVLRD 482

  Fly   327 S-LGGNS-QTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQ 389
            | :||.. :|.|||.:||.......|||||:||:|.:.:          |..:|...|...|.|
  Fly   483 SFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKEL----------SVESIPSKRMPDANL- 536

  Fly   390 LELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRN-ADLKTNL- 452
                            |:|::||...::.         .|||....|:.:.....| |...||.
  Fly   537 ----------------GSTSMSDIVCQSS---------TQRLFPCASSTSMPGGGNQAQQHTNTA 576

  Fly   453 -DLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPVY--DSDI 514
             |||:                                            :....:||.|  ....
  Fly   577 NDLNR--------------------------------------------SQKPTSKPTYPTSGQQ 597

  Fly   515 ITKAKKDLERERELLMSRSLPGIQNQN 541
            :.:.|...:||..:::::||...:.:|
  Fly   598 LVQRKGSSQREASMMLTKSLAQFRGRN 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	123/363 (34%)
		KISc	13..370	CDD:214526	123/369 (33%)
		KASH_CCD	409..589	CDD:291334	22/138 (16%)
		RasGAP	<685..750	CDD:295371
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	123/360 (34%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	121/356 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940