Protein Alignment Klp31E and kif1b

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_068072796.1
• Gene: kif1b / 369190
• ZFINID: ZDB-GENE-030820-1
• Length: 1927
• Species: Danio rerio
• Alignment Length: 1308
• Identity: 308/1308 - (23%)
• Similarity: 497/1308 - (37%)
• Gaps: 414/1308 - (31%)

  Fly    12 SSVRVAVRIRPQNSRE-------LIDMCRICTTV----TLGEPQIFLGSDKAFTFDYVFDTN--- 62
            :||:||||:||.||||       :|.|....||:    ...||       |.|:|||.:.::
Zfish     4 ASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPKNPKEP-------KTFSFDYSYWSHTSP 61

  Fly    63 -----SNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIP 122
                 ::|..:|:|..::::.....|||..:.||||||:||:||| .|...|.      |.||||
Zfish    62 DDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTM-MGKQEEG------QEGIIP 119

  Fly   123 RAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASG 187
            :....:|..|........|          :|:.|.|:|:|.|.:.|||:|.|| .|.::.|
Zfish   120 QLCEELFEKINDNNNEEIS----------YSVEVAYMEIYCERVRDLLNPKNK-GNLRVRE---- 169

  Fly   188 QITISGASIKPIYQPH-------------DALKYLQQGALARTTASTKMNDQSSRSHALFTI-FV 238
                     .|:..|:             |....:..|..|||.|:|.||:.||||||:||| |.
Zfish   170 ---------HPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFT 225

  Fly   239 RRQRLLTPSDNVPDNDLET-LTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISA 302
            :|:     .|:  :.||.| ..||...||||||||...|.|.|.|.:||.:||..|..||..|||
Zfish   226 QRK-----YDS--ETDLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISA 283

  Fly   303 LGD---------KSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYAN 358
            |.:         |.|:...:|||||.||.||:::|||||:|.|:|.:||:|.:|.|||:||:||:
Zfish   284 LAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYAD 348

  Fly   359 RARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCE---------GNTTISDTF 414
            ||:.||....||:|.:::.:.:|:.|::.|: |||..:....|:|.|         |:..:.|..
Zfish   349 RAKQIKCNAVINEDPNAKLVRELKDEVSRLK-ELLRAQGLGDILDIEPMGDDCLGSGSKYLKDIH 412

  Fly   415 NENK---LLLSEIKR--------------------------------LQQRLKS----------- 433
            | ||   ||.||.:|                                :|:|:.|
Zfish   413 N-NKHRYLLASENQRPGHFSTAPMGCLTASPSSGSLCSQAGLQSVSSIQERIMSTPGGEEAIERL 476

  Fly   434 -----------------LQSTIATLTQRNA--------------------------DLKTNL--- 452
                             |:.|.|...:|.|                          |..|:|
Zfish   477 KESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKFGPDRPTSLSIE 541

  Fly   453 DLNKWTSDD----------------------------NSDVEIAKVVGQYMLEIEELQTKLIESE 489
            |.:.::|:.                            |.|..:::.:..|   |::..|::.:::
Zfish   542 DFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDPLMSECLLYY---IKDGITRVGQAD 603

  Fly   490 EHRKQ------MEIKAT----TSPRNA--------KPVYDSDIITKAKK-----DLERERELLMS 531
            ..|:|      ..||..    .|.|||        :|...|:.....|:     .|.....::|.
Zfish   604 AERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETYVNGKRVNSAVQLRSGNRIIMG 668

  Fly   532 RS---------LPGIQNQNVSSEETEVASSD-SEAEEVVKDLEAIDNDIEMRTKLIE-------Q 579
            ::         ....:.:...|.||.|...| :.|:..:.:.:.||...||..:|.|       :
Zfish   669 KNHVFRFNHPEQARAEREKTPSAETPVEPVDWTFAQRELLEKQGIDMKQEMEKRLTEMEILYKKE 733

  Fly   580 LELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTDY---ESK 641
            .|..:...||.|..||.||..|..::|           ..:.:..||.::..::.:.:.   :.|
Zfish   734 KEEADQLLEQQRLVYESKLQELQKQVE-----------TRSLAAETPDEEEEEEEEDEVPWTQHK 787

  Fly   642 ISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQ--------- 697
            ....|...||.:..|...:|  .||..:.|       .|.|.....|:|.||:..|
Zfish   788 YELAQWAFRKWRYHQFTSLR--DQLWGNAV-------YLKEANAISVELKKKVQFQFVLLTDTLY 843

  Fly   698 ---------SNRHKQEESRKSKEIAQLLKEQRRQKNAV--LTLEAKVSAKEQILKRKTEEVIALR 751
                     ....|:.::|........::.|..:..|.  .:|| |:..:...::...:....:.
Zfish   844 SPLPPELLPPEPEKERDARPFPRTVVAVEVQDLKNGATHYWSLE-KLKQRLDQMREMYDRAGEMA 907

  Fly   752 KSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRN--ILHAARNRQL------------- 801
            .|.:|..|:.|          |.|......|..|..|..:  |.|...|.:|
Zfish   908 SSNQGDDGEGA----------LTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTTD 962

  Fly   802 --ITQLEKELERLILEREDLSRELNIMENGQTADRQTDEFNEVDN-------------------- 844
              ||:|..|.:.   |.||...:...::: .::|..|:|.:::.:
Zfish   963 SEITELADERQS---EMEDFMDDEAFVDD-TSSDAGTEEGSDIFSDGQDPFYDRSPWFILVGRAF 1023

  Fly   845 -LKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDE----------VSTVAEAKF--- 895
             ..:|:.| ...:.|....:.|..|.:..::..|..|.:  ||          .|..|:..|
Zfish  1024 VYLSNLLY-PVPLVHRVAVVTEKGDVRGFLRVGVQAIAA--DEEAPDYGSGVRQSGTAKISFDNE 1085

  Fly   896 ILQKFSDTAIVMS-CNLAIAESHLQEKESLLKEVKQESGIQQQILQHFLSQNSNVHIADIFDSLN 959
            ..:|...|::.|: ..|::.|..:.|.:....||...|....:|                 :.::
Zfish  1086 YFKKNDFTSVAMTRSGLSLEELRIVEGQGQSSEVITPSEEMNRI-----------------NEMD 1133

  Fly   960 LKGSNIASSVNPGSQKSLISNATY----------DIPQD-----------DKNSEFHQVEMRRTT 1003
            ||..|:.:.:..|..:.|...:.:          .||.:           .::.|....|..:.|
Zfish  1134 LKLGNVDTKLGDGLAEHLEVGSIFTFRVTVLQASGIPAEYADIFCQFNFLHRHDEAFSTEPLKNT 1198

  Fly  1004 SRSPSPLG 1011
            .|. :|||
Zfish  1199 GRG-APLG 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	147/394 (37%)
		Mplasa_alph_rch	<372..>748	CDD:275316	98/567 (17%)
		SMC_prok_B	622..>899	CDD:274008	60/350 (17%)
		Rcc_KIF21	798..870	CDD:410202	17/107 (16%)
kif1b	XP_068072796.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	149/400 (37%)
		Kinesin_assoc	357..596	CDD:465047	39/243 (16%)
		FHA_KIF1B	571..680	CDD:438779	18/111 (16%)
		GBP_C	<680..754	CDD:293879	20/73 (27%)
		KIF1B	889..937	CDD:463574	9/57 (16%)
		KIF1B	<999..1021	CDD:463574	0/21 (0%)
		DUF3694	1373..1529	CDD:463599
		PH_KIFIA_KIFIB	1808..1910	CDD:269939