Protein Alignment Klp31E and cos

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 246/1173 - (20%)
• Similarity: 440/1173 - (37%)
• Gaps: 359/1173 - (30%)

  Fly    40 LGEPQIFLGSD--------------KAFTFDYVFDTNSNQCDIYSDCVEKLVDSTLHGYNATVLA 90
            ||.|....|.|              ......:...::|:|..:|...|..|:...|.|::|:|:.
  Fly   109 LGLPSALPGGDPMDSIAAGLIQVGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVT 173

  Fly    91 YGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLA 155
            |||.|.||:||: .|...:...:||.: |::...||.|||.|        |.||    ...:::.
  Fly   174 YGQRGQGKSYTL-YGNVQDPTLTDSTE-GVVQLCVRDIFSHI--------SLHP----ERTYAIN 224

  Fly   156 VQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTAS 220
            |.::|:...|:.|||                |...|...::..::.      :||.|..||
  Fly   225 VGFVEICGGDVCDLL----------------GMGNIHCTNVDAVFH------WLQVGLSAR---- 263

  Fly   221 TKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFVDLAGSERLKRTQATGERARE 285
                 ||..:|.|||:.:.:|  ....:.:..:.|.|.:    |.||.|:||      .|::. .
  Fly   264 -----QSLPAHTLFTLTLEQQ--WVSKEGLLQHRLSTAS----FSDLCGTER------CGDQP-P 310

  Fly   286 GISINCGLLALGNCISALGDKSKRAL------HVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSD 344
            |..::.||..|...||.|.|.   .|      ::||..:.||.||:||.||.:|||:|.||||.:
  Fly   311 GRPLDAGLCMLEQVISTLTDP---GLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLE 372

  Fly   345 RDFMETLNTLKYANRARNIKNKVKINQDQSSRT--------ISQLRREIAALQ---------LEL 392
            ....|||..|::|.:.:.::|.|.:|......|        :.:.......|.         |:.
  Fly   373 EHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQF 437

  Fly   393 LEYKQGKLIVDCEG----------NTTISDTFNENKLLL----------SEIKRLQQRL------ 431
            ...:..||:.:.||          .|.:.....|..|.|          :|..|.|::|
  Fly   438 AASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQLVPILEA 502

  Fly   432 ---KSLQSTIATLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRK 493
               :.:.|..|.....|:|.:.:.|......|.:..:|      ..|.|..: :|..:..|:|.:
  Fly   503 EEPEDVNSEAANSESPNSDNENDTDNESHRPDLDDKIE------SLMEEFRD-KTDALILEKHAE 560

  Fly   494 QMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQ-NQNVSSEE----TEVASSD 553
            .:    :..|:......|.:|..:..::...:|::.:......:| ..::|:.|    ..|||..
  Fly   561 YL----SKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQ 621

  Fly   554 S----EAEEVVKDLEAIDND--------IEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIE 606
            .    :.|.||..||:...:        ....|..||||              ::||..|..:||
  Fly   622 PPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQL--------------QKKLRKLVAEIE 672

  Fly   607 NTQKE----------RDDVLANMTTSVSTPSK----------------DSLKK------VKTDYE 639
            ..|::          :.:::|.:..:..|.|.                |..||      |:...:
  Fly   673 GKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLGKALVQGRDQ 737

  Fly   640 SKISHMQTEI----RKLQN-AQREHI--RSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQ 697
            |:|....|.|    |:|:: :..:||  .|.|::|..:..:|..|.:.::|:       ||:.::
  Fly   738 SEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQ-------KKLRKE 795

  Fly   698 SNRHKQEES-----RKSKEIAQLL-------KEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIAL 750
            .....|.|:     |:|:|..:.|       ::|.||..||   :|:::....||:.|::.:
  Fly   796 CKLRCQMEAELAKLRESRETGKELVKAQGSPEQQGRQLKAV---QARITHLNHILREKSDNL--- 854

  Fly   751 RKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENL--YRNILHAARNRQLITQLEKELER-- 811
             :.|.|...|                  .:.||...||  .|::|...|     ..|:::|:|
  Fly   855 -EEQPGPEQQ------------------ETLRHEIRNLRGTRDLLLEER-----CHLDRKLKRDK 895

  Fly   812 LILEREDLSRELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFE--------- 867
            ::.::|    |..::|                        ..|.||.:..|| ||:
  Fly   896 VLTQKE----ERKLLE------------------------CDEAIEAIDAAI-EFKNEMITGHRS 931

  Fly   868 -DTKDTVQSHVNK--IQSLLDEVSTVAEAKFILQKF-------SDTAIVMSCNL----------- 911
             ||.|.:|....:  :.:.|:.:|| .|.:.:|.|:       .|::..:...|
  Fly   932 IDTSDRIQREKGEQMLMARLNRLST-EEMRTLLYKYFTKVIDLRDSSRKLELQLVQLERERDAWE 995

  Fly   912 --------AIAESHLQ-EKESLLKEVKQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNIAS 967
                    |:.::.|: |:.::|.:.:.|..: ..:|:|...:.|                  ||
  Fly   996 WKERVLSNAVRQARLEGERNAVLLQRQHEMKL-TLMLRHMAEETS------------------AS 1041

  Fly   968 SVNPGSQKSLISNATYDIPQDDKNSEFHQVEM-------RRTTSRSPSPLGNSDPFDKSPKVRRR 1025
            |.:.| :::|.....  .|....:|:|.....       .:...::|.|:......||.....:|
  Fly  1042 SASYG-ERALAPACV--APPVQASSDFDYDHFYKGGGNPSKALIKAPKPMPTGSALDKYKDKEQR 1103

  Fly  1026 TAK 1028
            :.:
  Fly  1104 SGR 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	96/343 (28%)
		Mplasa_alph_rch	<372..>748	CDD:275316	91/489 (19%)
		SMC_prok_B	622..>899	CDD:274008	69/333 (21%)
		Rcc_KIF21	798..870	CDD:410202	14/83 (17%)
cos	NP_477092.1	Kinesin	140..389	CDD:459720	91/309 (29%)
		SMC_N	660..>999	CDD:481474	80/419 (19%)