Protein Alignment Klp31E and Klp3A

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Alignment Length: 1192
• Identity: 324/1192 - (27%)
• Similarity: 540/1192 - (45%)
• Gaps: 260/1192 - (21%)

  Fly    12 SSVRVAVRIRPQNSRELIDMCRICTTVTL-GEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEK 75
            |.|.||:|:||....||...|||....:. |.||:.:..::::|::||||.:.:|.|::..||:.
  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQA 71

  Fly    76 LVDSTLHGYNATVLAYGQTGSGKTYTMGTGF-----DHESESSDSVQLGIIPRAVRHIFSGIEQL 135
            .|...|:|||.|:||||||||||||||||.|     ||         :|:|||||..||:.|.::
  Fly    72 KVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH---------VGVIPRAVHDIFTAIAEM 127

  Fly   136 EGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIY 200
            :    ||.       :|::...::|||.|..:||.....::.......:...:|.:.|.:...:.
  Fly   128 Q----SEF-------RFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVT 181

  Fly   201 QPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFV 265
            .......:|.:|:..|..|:|.||:.||||||:||:.:...:|        |......||:|:.|
  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL--------DGKQSVTTSRFNLV 238

  Fly   266 DLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGG 330
            |||||||..:|.|:|:|.:||::||.|||||||.|:||| ..:.|.::|||.|||||||||||||
  Fly   239 DLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYRQSKLTRLLQDSLGG 302

  Fly   331 NSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLE- 394
            ||.|||||||||:|.:..|||:||:||:||..||||..:|.|..:..::.|:..|..|::|||.
  Fly   303 NSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSG 367

  Fly   395 YKQGKLIVDCEGNTTISDTFNENKLL-----LSEIKRLQQRLKSLQ-----------STIATLTQ 443
            .|....::...|...:.....|..|.     .:||:||::::::||           .::..||:
  Fly   368 GKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTE 432

  Fly   444 RN-----------------ADLKTNLDL-------NKWTSDDNSDVEIAKVVGQYMLEIEELQTK 484
            :.                 ::||..||.       |:.|:.||...:.:.:|.:..:|::..|.:
  Fly   433 KEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEE 497

  Fly   485 LIESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEV 549
            | ||:.|..:..:.:.:.....:...|            ...|:|.|.|      :..::::...
  Fly   498 L-ESQGHESRQRLSSRSHTEGGESGGD------------EVHEMLHSHS------EEYTNKQMNF 543

  Fly   550 ASSDSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYC--KIENTQKER 612
            |.          :|..|:..::::.:|.|::....||.:.    .:|.:.:..|  ||::.:.||
  Fly   544 AG----------ELRNINRQLDLKQELHERIMRNFSRLDS----DDEDVKLRLCNQKIDDLEAER 594

  Fly   613 DDVLANMTTSVSTPSKDSLKKVKTDYESKISHMQTEI----RKL-QNAQREHIRSKQQLKSHEVR 672
            .|::..:.   :..|||...|:..:...::..::.||    ||| ..|....||.|::.|
  Fly   595 RDLMDQLR---NIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREK----- 651

  Fly   673 IGTLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKE 737
            |..|..|:..:|.:||||::.|..:|.:.:|.:..:.||:.||..:.|:.::.::..:...|.:.
  Fly   652 IQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQR 716

  Fly   738 QILKRKTEEVIALRK-------SQRGKSGQR--------APAHLTSKIATLDGFSTR-------- 779
            |:||||.||.:|..|       .|.....||        :.|..::..|..|.:..|
  Fly   717 QVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSL 781

  Fly   780 -SARHRWENL------YRNILH------------AARNRQLITQLEKELERLILEREDLSRELNI 825
             .|.|..|.|      ..|..|            ||...:::..||:|||
  Fly   782 IDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELE--------------- 831

  Fly   826 MENGQTADRQ-----TDEFNEVDNLKTNISYIQEN----------------------------IE 857
            |.|.|.:|.|     ||..:.:.:|...:..:.|:                            ::
  Fly   832 MRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLD 896

  Fly   858 HVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHL---- 918
            .::..:::.:..:|.....:..:||..:| ..:|:.:...:|.|  .::.:.|...||:..
  Fly   897 ELRAQLLDAQQQEDAASKRLRLLQSQHEE-QMLAQQRAYEEKVS--VLIRTANQRWAEARSPAED 958

  Fly   919 QEKESLLKEVKQESGIQQQILQHFLSQNSNVHIA------DIFDSLNLKGSNIASSVNPGSQKSL 977
            |::..:|:|:.......||.|....::|.:...|      |:.||.         .:..|::..:
  Fly   959 QQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSF---------QIVDGNETVV 1014

  Fly   978 ISNATYD---IPQDDKNSEFHQVEMRRTTS------RSPSPLGNSDPFD-------------KSP 1020
            :|:.:.|   :|...|:... |.:.|...|      .:.:.||||....             |..
  Fly  1015 LSDVSDDPDWVPSTSKSKRI-QSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGC 1078

  Fly  1021 KVRRR-TAKRQDLLFGDTELSE 1041
            |.|.: |.||...|.|:...||
  Fly  1079 KCRTKCTTKRCGCLSGNNACSE 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	154/357 (43%)
		Mplasa_alph_rch	<372..>748	CDD:275316	91/423 (22%)
		SMC_prok_B	622..>899	CDD:274008	74/356 (21%)
		Rcc_KIF21	798..870	CDD:410202	14/104 (13%)
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	154/357 (43%)
		Smc	<453..>985	CDD:440809	119/590 (20%)
		Metallothio	<1071..1115	CDD:395080	10/30 (33%)