Protein Alignment Klp31E and Kif4b

DIOPT Version :9

• Sequence 1: NP_001162935.1
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_017449986.2
• Gene: Kif4b / 299255
• RGDID: 1564044
• Length: 1224
• Species: Rattus norvegicus
• Alignment Length: 1187
• Identity: 336/1187 - (28%)
• Similarity: 534/1187 - (44%)
• Gaps: 268/1187 - (22%)

  Fly    10 KDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVE 74
            |:..||||:|.||...:|:.:.|::|.:...|:||:.:|:||:||:|:|||.::.|.::::..|.
  Rat     6 KEIPVRVALRCRPLVPKEIGEGCQVCLSFVPGKPQVVIGTDKSFTYDFVFDPSTEQEEVFNTAVA 70

  Fly    75 KLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSS 139
            .|:.....||||||||||||||||||:||..:  .:...|...:|:|||.::.:|..:|:...|
  Rat    71 PLIKGIFKGYNATVLAYGQTGSGKTYSMGGAY--RANQEDEPTIGVIPRVIQLLFKEMEEKRDS- 132

  Fly   140 TSEHPAAGGSPQFSLAVQYIELYNEDIFDLL-DPFNKNSNFKIHEDASGQITISGASIKPIYQPH 203
                       :|:|.|.|:|:|||:|.||| ....|.|...|.||....|...|.:.|.:....
  Rat   133 -----------EFTLRVSYLEIYNEEILDLLCSSCEKASQIHIREDPKAGIKTVGLTEKTVSVAS 186

  Fly   204 DALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFVDLA 268
            |.:..|:||..|||.|:|.||.|||||||:||:|:|:::....|        .:..||...||||
  Rat   187 DMVSCLEQGNNARTVAATAMNSQSSRSHAIFTVFIRQRKKTDKS--------SSFHSKLCLVDLA 243

  Fly   269 GSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQ 333
            ||||.|:|:|.|:|.||||:||.|||.|||.|||||| .|:...||||||||||||||||||||.
  Rat   244 GSERQKKTKAEGDRLREGININRGLLCLGNVISALGD-GKKGSFVPYRDSKLTRLLQDSLGGNSH 307

  Fly   334 TLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQG 398
            |||||||||:|....||||||:||:|||.|||:..||.|..:..::.|:.::..|::.||:...|
  Rat   308 TLMIACVSPADSSLEETLNTLRYADRARKIKNEPVINTDPQTAELTHLKHQVQQLRVLLLQAHGG 372

  Fly   399 KL--IVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQR-------NADLKTNL-- 452
            .|  .:..|.:.::.....:|:.|..|.::|...|.......|.:.:|       |..|.|.|
  Rat   373 SLPGSIIAEPSESLQSLMEKNQSLGEENEKLSHALSEAAGQTAQMLERIILTEQANEQLNTKLQE 437

  Fly   453 ---------DLNKWTS--DDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNA 506
                     ||.|.|.  :|...:|..:::......:..|..:.:.:.|...::|.:...||::.
  Rat   438 LSDHVACKVDLQKLTETLEDQELIEKIEIIRSLQQAVIHLSDENVVATESAMELETQVAISPKSR 502

  Fly   507 KPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIE 571
            :   .||.:|                              |:.|...:   ::.|:|..::..:.
  Rat   503 R---SSDALT------------------------------TQHALRQA---QMSKELTELNKALA 531

  Fly   572 MRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSL----K 632
            ::..|..::.....:.:.:...||..:..|..::.:.|||::.:|.::..:....::..|    :
  Rat   532 VKEALARKITFNGGQLQPIHCQYEVNIRSLESEVASLQKEKEQLLLDLQLAKKDANQAKLGEHRR 596

  Fly   633 KVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQ 697
            |...:.|::|:    :::|..:.|.:.::.|:   |.|..:..|..|:..:|..:|:||::|.:.
  Rat   597 KCLQELEAQIA----DLKKKLSEQSKLLKLKE---STENTVSKLTLEIQMMKTQRVQLMRQMKED 654

  Fly   698 SNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRK---------- 752
            :.:.:|.:.:|.||:.||.::.|:::..:|.||.....:..:|:|||||..|..|
  Rat   655 AEKSRQWKQQKDKEVIQLREQDRKRRYELLKLERDFQKQSNVLRRKTEEAAAANKRLKDALQKQR 719

  Fly   753 ---------SQRGKSGQRAPAH--LTSKIATLDGFSTRSARHRWENLY--RNIL----------- 793
                     ..||..|..|...  |:::|..:  .||...:|...:|.  |.||
  Rat   720 DAADKRKETQNRGLEGTEARVKNWLSNEIEVM--VSTEDVKHHLNDLLEERKILALDMAQLKENK 782

  Fly   794 ----------------------HAARNRQLITQ----LEKELERLILEREDLSRELNIMENGQTA 832
                                  |::.....||:    ||.|:|....:..||.::|...|:....
  Rat   783 EPGENPPLKLQKWTFASDEVCGHSSEPEDSITKQIRSLEAEMELRNAQIADLQQKLLDAESEDRP 847

  Fly   833 DRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFE-DTKDTVQSHVNKIQSLLDE----VSTVAE 892
            .|..:....|...|..:.|:...:...:..:.|.| :.|.:..||....:.||:|    |...||
  Rat   848 KRHWESIATVLEAKCALKYLVGEVVSSKLQVSELESNLKQSQASHSKTQKMLLEEQSHLVQVEAE 912

  Fly   893 AKFILQKFSDTAIVMSCNLAIAESHLQEKE-SLLKEVKQE-----------SGIQQQIL------ 939
            .|..|.|              ||...|||| .||.:::|.           ||.:||:|
  Rat   913 WKAELSK--------------AEQKHQEKELYLLSQLQQSQMAEQRLEVSVSGKEQQLLSTLQCQ 963

  Fly   940 --------------QHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLISNATYD----IP 986
                          |..|.:|..:.                       ||..:...|.|    :|
  Rat   964 EDQFRKMQELCEQNQQLLQENEAIR-----------------------QKLSLFQGTKDQKSHLP 1005

  Fly   987 QDD---KNSEFHQVEMRRTTSR---------------------SPSPLGNSDPFDKSPKVRRRTA 1027
            :||   .:|.|:.:......||                     |.|...:.|..||..|.|:.
  Rat  1006 RDDLQSPDSSFNYIPPPPKASRVRGKFLDQSMDIDDLNSYPEYSMSESEDGDGHDKEWKPRKL-- 1068

  Fly  1028 KRQDLLFGDTELSEQTF 1044
                     .::|.:||
  Rat  1069 ---------AKVSRKTF 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	171/352 (49%)
		KISc	13..370	CDD:214526	174/357 (49%)
		KASH_CCD	409..589	CDD:291334	30/199 (15%)
		RasGAP	<685..750	CDD:295371	20/64 (31%)
Kif4b	XP_017449986.2	KISc_KIF4	8..338	CDD:276823	171/352 (49%)
		Smc	<370..742	CDD:224117	78/414 (19%)
		SMC_prok_B	<594..923	CDD:274008	77/351 (22%)
		SET	1074..>1113	CDD:394802	2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010