Protein Alignment Klp31E and Kif7

DIOPT Version :9

• Sequence 1: NP_001162935.1
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_218828.5
• Gene: Kif7 / 293047
• RGDID: 1310310
• Length: 1341
• Species: Rattus norvegicus
• Alignment Length: 1249
• Identity: 312/1249 - (24%)
• Similarity: 515/1249 - (41%)
• Gaps: 347/1249 - (27%)

  Fly    10 KDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVE 74
            :::.||||:|:||...:||:...:.|..|.....:|.||.|:.|.|..|...::.|..:|..||:
  Rat    12 EEAPVRVALRVRPLLPKELLHGHQSCLQVEPERGRITLGRDRHFGFHVVLGEDAGQEAVYQACVQ 76

  Fly    75 KLVDSTLHGYNATVLAYGQTGSGKTYTMG---TGFDHESESSDSVQLGIIPRAVRHIFSGIEQLE 136
            .|:::...|:||||.||||||||||||||   ....||.|.      ||||||:...|..|::.:
  Rat    77 PLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLHEDEQ------GIIPRAMAEAFKLIDEND 135

  Fly   137 GSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQ 201
            ......|            |.|:|||.|:..|||:....:.:.::.||..|.:.:.|.....:..
  Rat   136 LLDCLVH------------VSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLCGVKEVDVEG 188

  Fly   202 PHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQ-----RLLTPSDNVPDNDLETLTSK 261
            ..:.|..|:.|..||.|.:|..|..|||||.:||:.:.::     ||..|...      ..|.||
  Rat   189 LDEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRAPTRLPRPGAG------HLLVSK 247

  Fly   262 FHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQD 326
            |||||||||||:.:|.:||||.:|.|.||..||||||.||||||..:|..|:||||||:||:|:|
  Rat   248 FHFVDLAGSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKD 312

  Fly   327 SLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKIN---------QDQS-------- 374
            |||||::|:||||||||..||.||||||.||:||:||:|:..:|         ::|:
  Rat   313 SLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERVPEEQAAGARGPPR 377

  Fly   375 ----SRTISQLRREI------AALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQ- 428
                :|.|.:.||.:      ||:...|     |.....|...|:.:         .|.::.||
  Rat   378 HRSETRIIHRGRRVLCPGVGSAAVAPGL-----GTECARCRARTSAA---------YSLLRELQA 428

  Fly   429 ----------------------------------------------------------QRLKSLQ 435
                                                                      |:|..||
  Rat   429 EPGLPGAAARKVRDWLCAVEGERSALSSASGPDSGIESAPADDQAAQGTSGRKGDEGAQQLLILQ 493

  Fly   436 STIATLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEI--- 497
            |.:|.|.:.|.|....|:               ..:.||.|:.:.|:.:..|..|.|.::|:
  Rat   494 SQVARLEEENRDFLAALE---------------DAMEQYKLQSDRLREQQEEMVELRLRLELAQP 543

  Fly   498 -------------------------------KATTSPRNAKPVYDSDIITKAKKDLERERELLMS 531
                                           ...|.||...|..:.....:.....|.:.|||..
  Rat   544 GWGAPGLLQGLSPGSFVPRPHTAPLGGAHTHMTGTMPRTCLPGEEVSSEQQVANGKEAKAELLAQ 608

  Fly   532 RSLPGIQNQNVSSEETE------------------------------------------------ 548
            ....|..:...|.||.|
  Rat   609 VDKLGSASSTTSEEEEEEEEEPPRRTLHLRRNGISNWSQRAGVRPGSPPDRKGPEVCPEEPAAAI 673

  Fly   549 -----VASSD------------------SEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQM 590
                 |..|.                  ::|::.:::| ||  :|.|:.:||.:|..|....:.:
  Rat   674 PAPQAVGGSKAPGQTRQAPAAMASEWRLAQAQQKIREL-AI--NIRMKEELIGELVRTGKAAQAL 735

  Fly   591 RTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVK-TDYESKISHMQTEIRKLQN 654
            ...:.:::..|..:.|..:.|..:....:........:|:.::.: .::..:::..|::::.|
  Rat   736 NRQHSQRIRELEQEAERVRGELCEGQRQLRELEGREPQDASERSRLQEFRKRVAAAQSQVQVL-- 798

  Fly   655 AQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLLKEQ 719
              ||..::.::|.|...:..|...||..    .|:||::...|..|..:||:.:.:   :|..|.
  Rat   799 --REKKQATERLVSLSAQSETRLQELER----NVQLMRRQQGQLQRRLREETEQKR---RLETEM 854

  Fly   720 RRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQR-GKSGQRAPAHLTSKIATLDGFSTRSARH 783
            .::::.|..||.|...:::|||.||||:.|.::::| |.:|         .:.:|:.......:.
  Rat   855 NKRQHRVKELELKHEQQQKILKIKTEEIAAFQRNRRSGSNG---------SVVSLEQQQKIEEQK 910

  Fly   784 RWENLYRNILHAARNRQLITQLEKEL---ERLILEREDLSRELNIMENGQTADRQTDEFNEVDNL 845
            :|  |.:.:....:.|:.:.:|.:||   |.::.::|.|.:|...:|:.:.  |.:...||
  Rat   911 KW--LDQEMEKVLQQRRALEELGEELRKREVILAKKEALMQEKTGLESKRM--RSSQALNE---- 967

  Fly   846 KTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCN 910
              :|..:...:||:::.:.  |.:....|......|.:..|:.|:.
  Rat   968 --DIVRVSSRLEHLEKELS--EKSGQLRQGSALNQQQIRGEIDTLR------------------- 1009

  Fly   911 LAIAESHLQEKESLLKE-VKQESGIQQQILQHFLSQNSNVHIADIFDSLN--LKGSNIASSVNPG 972
                    |||:||||: ::.:|.::|..|.....:.:...:.:..::|:  ::..|.|.:..
  Rat  1010 --------QEKDSLLKQRLEIDSKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCR-- 1064

  Fly   973 SQKSLISNATYDIPQDDKNSEFHQVEMRRTTSRSPSPLGNSDP-------FDKSPKVRRRTAKRQ 1030
             |:.|.::|          |...|.||......  |.|.:|:.       |||...:|.. ..:|
  Rat  1065 -QRVLRASA----------SLLSQCEMNLMAKL--SYLSSSETRALLCKYFDKVVTLREE-QHQQ 1115

  Fly  1031 DLLFGDTE--LSEQ 1042
            .:.|.:.|  |.||
  Rat  1116 QIAFSELEMQLEEQ 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	159/359 (44%)
		KISc	13..370	CDD:214526	161/364 (44%)
		KASH_CCD	409..589	CDD:291334	46/343 (13%)
		RasGAP	<685..750	CDD:295371	20/64 (31%)
Kif7	XP_218828.5	KISc	15..356	CDD:214526	161/364 (44%)
		KISc_KIF4	15..350	CDD:276823	159/358 (44%)
		COG1340	701..1040	CDD:224259	80/400 (20%)
		Utp11	848..1028	CDD:295201	48/230 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820