DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and Kif27

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_932167.1	Gene:	Kif27 / 246209	RGDID:	621071	Length:	1394	Species:	Rattus norvegicus

Alignment Length:	1340	Identity:	353/1340 - (26%)
Similarity:	552/1340 - (41%)	Gaps:	404/1340 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEKLVD 78
            ::|||||||...:|::...::|........||.:|.|:.||||:||..||.|.::||.|::.||.
  Rat     6 IKVAVRIRPLLCKEVLHNHQVCVRDIPKTQQIIIGRDRVFTFDFVFGKNSTQDEVYSTCIKPLVL 70

  Fly    79 STLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEH 143
            |.:.||||||.||||||||||||:|.|  |.:...|. |.||||||::.||..|
  Rat    71 SLIEGYNATVFAYGQTGSGKTYTIGGG--HVASVVDG-QKGIIPRAIQEIFQSI----------- 121

  Fly   144 PAAGGSP--QFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQPHDAL 206
               .|:|  .|.:.|.|||:|.||:.|||:......:..|.||..|...|.||....:....|.:
  Rat   122 ---SGNPNIDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVDSVEDVM 183

  Fly   207 KYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDL---ETLTSKFHFVDLA 268
            ..||.|..||.|.:|:||:.||||||:|||.|  .::...::...|.:.   ..:.|||||||||
  Rat   184 GLLQVGNAARHTGTTQMNEHSSRSHAIFTISV--CQVGKSAEATEDGEWCSHRHIVSKFHFVDLA 246

  Fly   269 GSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQ 333
            ||||:.:|..||||.:|.|.||.|||||||.||||||..:::.||||||:|:||||:|||||:::
  Rat   247 GSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHVPYRDAKITRLLKDSLGGSAK 311

  Fly   334 TLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQG 398
            |:||.|||||..||.|:||:||||||||||:||..:|....:..:.::..||..|: |.|:..|.
  Rat   312 TVMITCVSPSSSDFDESLNSLKYANRARNIRNKPTLNFSPQADRMDEMEFEIKLLR-EALQSHQA 375

  Fly   399 KLIVDCEGNTTISDTF-NENKL--LLSEIKRLQQRLKSLQSTIATLTQRNADLKTNLDLN----- 455
            .:   .:.:.|.|:.. ::|::  |..:|.:||:.....|..|........|||..:.||
  Rat   376 SI---SQTSQTASENVPDQNRIHSLEEQIAQLQEECLGYQDCIEQAFAFLVDLKDAVRLNQKQQH 437

  Fly   456 ---KWTSDDNSDVEIAKVV------GQYMLEIEE-------LQTKL------------------- 485
               :|.|...   |:.|.|      .|.:..:||       ||.|.
  Rat   438 KLQQWFSRTQ---EVRKAVLTPLPGNQSIGNLEEGPQHVTVLQLKRELKKYQCALAADQVVFTQK 499

  Fly   486 -IESEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLM----------SRSLP---- 535
             :|.||.|:||::.|..|..:|..:.::..:.:.:.:...|::||:          |.|:|
  Rat   500 ELELEELRRQMQLMAQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELAKRSSSMPTSTK 564

  Fly   536 ------------------------------------------------------GIQ-------- 538
                                                                  |.:
  Rat   565 ESCGDGPDARAPEKRPHTAPFDSHWGHYVYIPSRQDFKKVCSSSPVYSLDQVFAGFRTRSQMLMG 629

  Fly   539 -------------NQNVSSEETE------------------------VASSDSEAE--------- 557
                         :.|...|::|                        |..||::||
  Rat   630 HLEDQDEVLHCQFSDNSDDEDSEGQEKPRVRSRSHSWVKKPGSVCSLVEMSDTQAECQRSYLGNG 694

  Fly   558 ---------------EVVKDLEAIDN-----------DIEMRTKLIEQLELTNSRYEQMRTHYEE 596
                           :.::..|.|.|           :|.|:..||::|..|....:.:...|..
  Rat   695 DLKMESLQESQELNLQKLRTSELILNKAKQKMRELTINIRMKEDLIKELIKTGDNAKSVSRQYSL 759

  Fly   597 KLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVK--TDYESKISHMQTEIRKLQNAQREH 659
            |::.|..:.|..:.|..:....:.........|...|||  .::..|:...:..::.||..|::.
  Rat   760 KVTKLEHEAEQAKVELTETRKQLQELEGKDLSDVALKVKLQKEFRKKMDAAKLRVQVLQKKQQDS 824

  Fly   660 IRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQ------EESRKSKEI------ 712
            .:.......:|.|...|...::.||:.||:|.:::.::|.:.||      .:.:|.||:
  Rat   825 KKLASLSIQNEKRASELEQNVDHLKYQKVQLQRRLREESEKKKQLDAEVKRDQQKLKELQLNAGQ 889

  Fly   713 ----------------------------AQLLKEQRR-----------QKNAVLTLEAKVSAKEQ 738
                                        .|.|.|||:           |:..:..||.::..:|.
  Rat   890 GEGLHPKAEDTDAFNLNRRKGPFRSVDQLQKLDEQRKWLDEEVEKVLSQRQELEMLEEELKKREA 954

  Fly   739 ILKRKTEEVIALRKSQRGKSGQRAPAHL-TSKIATLDGFSTRSARHRWENLYRNILHAARNRQLI 802
            |:.:|  |.:...||           || ..|:.:....||.|.:           .:||    :
  Rat   955 IVSKK--EALLQEKS-----------HLENKKLRSSQALSTDSLK-----------ISAR----L 991

  Fly   803 TQLEKEL--ERLILEREDLSRELNIMENGQTADRQTDEF----NEVDNLKTN-----------IS 850
            ..|::||  :.|:||......::.|.|..|...|:.::.    |.||....:           :.
  Rat   992 NLLDQELSEKSLLLENSPTEEKVKISEQVQALQREREQLQRQRNSVDEKLRHGRVLSPKEEHLLF 1056

  Fly   851 YIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVS-------------TVAEAKFILQKFSD 902
            .::|.||.::.|| ||::  :::|:..:.::|....:|             .:||.:.||.|:.:
  Rat  1057 QLEEGIEALEAAI-EFKN--ESIQNRQSSLKSSFQNLSQSESNVLEKLVCLNIAEIRAILFKYFN 1118

  Fly   903 TAIVMSCNLAIAE--SHLQEKESLLKEVKQ-------ESGIQ---------------------QQ 937
            ..|    ||..||  ..||.||..:|.:::       ||.::                     |.
  Rat  1119 KVI----NLREAERKQQLQNKEMKMKVLERDNMVHELESALEYLRLQCDRRLTLQQKEHEQKMQL 1179

  Fly   938 ILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLISNATYDIPQDDKNSEFHQVEMRRT 1002
            :|.||..|:               |..|..::|....|         |.|.:|:..|::...|..
  Rat  1180 LLHHFKDQD---------------GEGIIETLNKYEDK---------IQQLEKDLYFYKKTSRDL 1220

  Fly  1003 TSRSPSPLGNSDPFDKSPKVRRRTAKRQDLLFGDTELSEQ 1042
            ..|.      .||...:.:.:|...:..|.  ||..|:.:
  Rat  1221 KKRL------KDPVQGAVQWQRTLTEHHDA--GDGVLNPE 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	174/354 (49%)
		KISc	13..370	CDD:214526	177/360 (49%)
		KASH_CCD	409..589	CDD:291334	58/371 (16%)
		RasGAP	<685..750	CDD:295371	21/115 (18%)
Kif27	NP_932167.1	KISc_KIF4	4..342	CDD:276823	174/354 (49%)
		KISc	5..348	CDD:214526	177/360 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..583		3/31 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..664		3/21 (14%)
		SbcC	<702..1222	CDD:223496	112/578 (19%)
		DUF4200	789..>884	CDD:290574	22/94 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1340
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1375..1394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820