Protein Alignment Klp31E and klp-19

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_499742.1
• Gene: klp-19 / 176750
• WormBaseID: WBGene00002229
• Length: 1083
• Species: Caenorhabditis elegans
• Alignment Length: 1115
• Identity: 318/1115 - (28%)
• Similarity: 496/1115 - (44%)
• Gaps: 178/1115 - (15%)

  Fly     8 INKDSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDC 72
            ::.|:|:||.||.||.|.||..:....|........||.:.....||||.||...|:|..:|...
 Worm     1 MSSDASLRVVVRARPMNGRETKEGASRCVQFYENTKQIVINESATFTFDAVFADTSDQESVYETT 65

  Fly    73 VEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEG 137
            ...|:|....|:||||||||||||||||||||   .::..:|.::.|||||.|..:|..|...|.
 Worm    66 ALPLLDRIFAGFNATVLAYGQTGSGKTYTMGT---EDNVGTDEMRRGIIPRLVSALFQRIMNTEA 127

  Fly   138 SSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASIKPIYQP 202
            ..:           |::.|...|:|.::::|||.|.....|  :|.|.. ..|:...:..|:...
 Worm   128 PES-----------FAVTVSMFEVYGDNVYDLLRPDKVKLN--VHGDEK-NCTVVNLTAVPVIDL 178

  Fly   203 HDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSKFHFVDL 267
            ..|||.|..|...||.|.|.||..||||||:||:||.:..       ..:.| ...::|...|||
 Worm   179 KGALKQLAVGCHYRTKAETAMNAMSSRSHAVFTVFVEKTA-------TAECD-SAFSAKLQLVDL 235

  Fly   268 AGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNS 332
            |||||||:|:|.|.|.:|||:||.|||.|...|:||..|.|   |:|||:|.:||:|||||||||
 Worm   236 AGSERLKKTEAEGNRMKEGININGGLLILSQVIAALATKQK---HIPYRNSVITRVLQDSLGGNS 297

  Fly   333 QTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQ 397
            .|:.:||:||:|.:..||||||:||:||:.||||..:|::..:..|:.|:.::..||.|..:.||
 Worm   298 FTVFLACISPADSNSQETLNTLRYADRAKQIKNKPIVNKNPKAEEIAILQAQLKRLQKENADLKQ 362

  Fly   398 GKLIVDCEGNTTISDTFNENKL--LLSEIKRLQQRLKS---LQS----TIATLTQRNADLKTN-L 452
            |  |...|  ...:|..|..::  |..|:.|..::||.   .||    .::.|||:|:.|:.: .
 Worm   363 G--IAPAE--VRFNDANNSAEILSLKEEVVRKTEQLKERAMKQSECIIRMSALTQKNSRLEEDKA 423

  Fly   453 DLNKWTSDDNSDV---------EIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKP 508
            .|....:|..:.|         |:.:.:.|.:.:.|| .|.|.:.:.....:..:..|
 Worm   424 KLQSMLTDVRNTVLNEEMLDAAEVVRSIQQVVGDTEE-STTLADDDNDETALGGQDDT------- 480

  Fly   509 VYDSDIITK------------AKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVK 561
            :||::.:.:            |.||..|::.|...|:......|. .||:|::....||.|..:.
 Worm   481 IYDTERLPELQAELDDLEKQIAMKDENRQKALDEQRAFIEAMQQR-ESEKTQLVVRISELETEMN 544

  Fly   562 DLEAIDNDIEMRTKLIEQLELTNSRYEQM----RTHYEEKLSVLYCKIENTQKERDDVLANMTTS 622
            .|......:....||.|:      |.:::    |.|.|:|      |:.|..|:..:....|..:
 Worm   545 KLRQEGKKVTTAAKLAEE------RRQKLKDLERQHAEDK------KVLNDMKKLQETRRRMEET 597

  Fly   623 VSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAK 687
            :. .::|.||.:||.....:...:.|..|.|..:::|.|...|:||      .|:...|:
 Worm   598 LK-KTEDELKNLKTQRLRLLREQRAEASKFQAFKQKHEREMAQMKS------KLQKREND----- 650

  Fly   688 VKLMKKMSQQS----NRHKQEESRKSKEIAQL-LKEQRRQKNAVLTLEAKVSAKEQILKRKTEEV 747
            |.:.|:|:.|.    .....|.:|.:|.:.:| ||...|:.:     ....||.:.:::.:.|..
 Worm   651 VAIQKRMTDQKLTVLQMRLTEANRANKTLRELNLKRANRKSS-----PTNASALQNMIEEELEHE 710

  Fly   748 IALRKSQRGKSGQRAPAH-LTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLEKE--- 808
            :..::|.......|...| |...|.|::.......:.|     |....|..|..::.:.|:|
 Worm   711 MCAQRSHWLCEDLRRQRHDLMQNINTVESMKFEGGKRR-----RISASADPNVSVVIEGEEEFEV 770

  Fly   809 ------------LERLILEREDLSRELNIMENGQTADRQTDEFNEVDNLKTNISYIQENIEHVQQ 861
                        ||.|..|.:|..|...|..|.:.|:.:.::............|.|. :.|:::
 Worm   771 KRQKELTFLRASLETLNEEIKDSLRNETIAGNEERANSRWEKVPAEMRPAFEAVYAQA-VAHIRK 834

  Fly   862 AI-MEFEDTKDTVQSHVNKIQSLLD-EVSTVAEAKFILQKFSDTAIVMSCNLAIAESHLQEKESL 924
            .| :||:..: |......||.|... |.....|.:.:..|:.:.|   .| |..|:|.|.||.:.
 Worm   835 EIELEFKLAR-TKSEFTAKIASKASHEEKRKKEDEEMRAKYRELA---QC-LEDAKSGLHEKIAF 894

  Fly   925 LKEVKQESGIQQQILQHFLSQNSNVHIADIFDSL----NLKGSNIASSVNPGSQKSLISNA---- 981
            |..:.:|:.:.:..:|.|.|..:  ...|:...:    ..|.:|....:.|..:......|
 Worm   895 LLCLIKENRVDENAIQQFESLKN--QFCDVEQKVKKASRRKTTNFMGGLTPKPELQRNERARRAV 957

  Fly   982 --------TYDIPQDD------KNSEFHQVEMRRTTSRSPSPLGNSDPFDKSPKVRRRTAKRQDL 1032
                    :.|:..||      |:.....|||.|||               ...|:||.|.....
 Worm   958 KYYGNVVNSEDVTMDDSRHQKRKDHSLLAVEMNRTT---------------DDNVKRRVAMSPIK 1007

  Fly  1033 LFGDTELSEQ 1042
            ...||.|:|:
 Worm  1008 CDDDTRLTEE 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	151/351 (43%)
		Mplasa_alph_rch	<372..>748	CDD:275316	91/415 (22%)
		SMC_prok_B	622..>899	CDD:274008	62/299 (21%)
		Rcc_KIF21	798..870	CDD:410202	18/87 (21%)
klp-19	NP_499742.1	KISc	6..326	CDD:276812	150/347 (43%)
		Smc	<339..>650	CDD:440809	76/342 (22%)
		YhaN	489..>919	CDD:443752	102/472 (22%)