Protein Alignment Klp31E and Kif3c

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: NP_032471.2
• Gene: Kif3c / 16570
• MGIID: 107979
• Length: 796
• Species: Mus musculus
• Alignment Length: 872
• Identity: 243/872 - (27%)
• Similarity: 386/872 - (44%)
• Gaps: 178/872 - (20%)

  Fly    13 SVRVAVRIRPQNSRE-------LIDMCRICTTVTLGEPQIFLGS-DKAFTFDYVFDTNSNQCDIY 69
            :::|..|.||.:.:|       ::.|......|||..|:...|. .|.||||.|:|.:|.|.|:|
Mouse    10 ALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLY 74

  Fly    70 SDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTM-GTGFDHESESSDSVQLGIIPRAVRHIFSGIE 133
            .:.|..|:||.|.|:|.||.||||||:|||||| ||..:.|..       |:||.|..|||:
Mouse    75 DETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELR-------GVIPNAFEHIFT--- 129

  Fly   134 QLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLL--DP-----FNKNSNFKIH-EDASGQIT 190
                     |.:...:.|:.:...|:|:|.|:|.|||  :|     ..:|....:: :|.|..:|
Mouse   130 ---------HISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVT 185

  Fly   191 ISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDL 255
            .:...|:.:         :..|..||...||.||:.||||||:|.|.|.      .|:...|...
Mouse   186 KNVKEIEHV---------MNLGNQARAVGSTHMNEVSSRSHAIFVITVE------CSERGSDGQD 235

  Fly   256 ETLTSKFHFVDLAGSERLKR----------TQAT----------------GERAREGISINCGLL 294
            .....|.:.||||||||..:          ||.|                |||.:|...||..|.
Mouse   236 HIRVGKLNLVDLAGSERQNKAGPNAAGGPATQPTAGGGSGSGSASGSASSGERPKEASKINLSLS 300

  Fly   295 ALGNCISALGDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANR 359
            ||||.|:||.  ..|:.|:||||||||||||||||||::|:|:|.:.|:...:.|:|:||::|||
Mouse   301 ALGNVIAALA--GNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANR 363

  Fly   360 ARNIKNKVKINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEI 424
            |:|||||.::|:|.....:.:.:.|||.|:.:|  .|:|                    :|....
Mouse   364 AKNIKNKPRVNEDPKDTLLREFQEEIARLKAQL--EKKG--------------------MLGKRP 406

  Fly   425 KRLQQRLKSLQSTIATLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLE--IEELQTKLIE 487
            :|...|.|...|..|...:.:.       :..|.:::..|........|.:||  :|:.....::
Mouse   407 RRKSSRRKKAVSAPAGYPEGSV-------IEAWVAEEEDDNNNNHHPPQPILEAALEKNMENYLQ 464

  Fly   488 SEEHRKQMEIKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASS 552
            .::.|.:.|..|...        |..::::.|:.|..|:|    :.|..::.:..::|.......
Mouse   465 DQKERLEEEKAAIQD--------DRSLVSEEKQKLLEEKE----KMLEDLRREQQATELLAAKYK 517

  Fly   553 DSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLA 617
            ..|::.::.....:|:..|.:    :.|||......:.:....|....:..:.|.|.:     |.
Mouse   518 AMESKLLIGGRNIMDHTNEQQ----KMLELKRQEIAEQKRREREMQQEMLLRDEETME-----LR 573

  Fly   618 NMTTSVSTPSKDSLKKVKTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNE 682
            ...:|:....:...||:|..| :|:..::.||   |:...|:||.:|.|:..:      ..:..|
Mouse   574 GTYSSLQQEVEVKTKKLKKLY-AKLQAVKAEI---QDQHEEYIRVRQDLEEAQ------NEQTRE 628

  Fly   683 LKFAKVKLMKKMSQQSNRHKQEESRKSKEIAQLL----KEQRRQKNAVLTLEAKVSAKEQILKRK 743
            ||...:.:       .|....||  |:|.:.:|.    :||.|.:..|   .|.|: ..|:.||.
Mouse   629 LKLKYLII-------ENFIPPEE--KNKIMNRLFLDCEEEQWRFQPLV---PAGVN-NSQMKKRP 680

  Fly   744 TEEVIALRKSQRGKSGQRAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLITQLE-- 806
            |..|           |.:.|....:::|...|   ...|:|.||:.  .|....:...|.::|
Mouse   681 TSAV-----------GYKRPISQYARVAMAMG---SHPRYRAENIM--FLELDVSPPAIFEMEFS 729

  Fly   807 --KELERLILEREDLSRELNIMENGQT 831
              :|.:..:|..|.|.|..:.:|...|
Mouse   730 HDQEQDPRVLHMERLMRLDSFLERPST 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	146/393 (37%)
		Mplasa_alph_rch	<372..>748	CDD:275316	73/381 (19%)
		SMC_prok_B	622..>899	CDD:274008	52/218 (24%)
		Rcc_KIF21	798..870	CDD:410202	9/38 (24%)
Kif3c	NP_032471.2	KISc_KIF3	9..367	CDD:276822	145/392 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..292		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..422		7/44 (16%)
		Smc	<452..>637	CDD:440809	39/222 (18%)
		Globular. /evidence=ECO:0000255	633..793		35/153 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	758..796