DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp31E and Kif21a

DIOPT Version :9

Sequence 1:NP_001162935.1 Gene:Klp31E / 34422 FlyBaseID:FBgn0032243 Length:1048 Species:Drosophila melanogaster
Sequence 2:XP_017171930.1 Gene:Kif21a / 16564 MGIID:109188 Length:1685 Species:Mus musculus


Alignment Length:1202 Identity:468/1202 - (38%)
Similarity:662/1202 - (55%) Gaps:216/1202 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 RIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEKLVDSTLHG 83
            |||||.::|.|:.|.|||:||.||||:|||.|||||||||||.:|.|..||:.|:|||::....|
Mouse    23 RIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYTQCIEKLIEGCFEG 87

  Fly    84 YNATVLAYGQTGSGKTYTMGTGFD---HESESSDSVQLGIIPRAVRHIFSGIEQLEGSSTSEHPA 145
            |||||.||||||:|||||||||||   .|.|.      |||.|||||:|..|::   ..||....
Mouse    88 YNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQ------GIISRAVRHLFKSIDE---KKTSAIKN 143

  Fly   146 AGGSPQFSLAVQYIELYNEDIFDL------LDPFNKNSNFKIHEDASGQITISGASIKPIYQPHD 204
            ....|:|.:..|::|||||::.||      :|..||.||.:||||::|.|...|.:.:.:....:
Mouse   144 GLPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPE 208

  Fly   205 ALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLL--TPSDNVPDNDL----------ET 257
            .::.|:.|||:||||||:||.|||||||:|||.|.:.|:.  |.::|..||.|          ||
Mouse   209 MMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLISESSPMNEFET 273

  Fly   258 LTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTR 322
            ||:||||||||||||||||.||||||:||||||||||||||.|||||||||||.|||||||||||
Mouse   274 LTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTR 338

  Fly   323 LLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAA 387
            ||||||||||||:||||||||||||||||||||||||||||||||.:|||::|:.|:.||.||..
Mouse   339 LLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITR 403

  Fly   388 LQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRNADLKTNL 452
            ||:||:|||.||.|:|.||..:|:|.|:||.:|.:|...|:.|:|::|.|:..|..|...|.:..
Mouse   404 LQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRARITQLVSEQ 468

  Fly   453 DLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESE---EHRKQMEIKAT-------TSPRNAK 507
            ...........:.||:.::..|:.|||:|:.||:|||   |:.::...:||       .|...:.
Mouse   469 ANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARSPYFSASSAFSP 533

  Fly   508 PVYDSD-----IITKAKKDLER---------------ERELLMSRSLPG---------------- 536
            .:..||     ||..||||||:               |......||:.|                
Mouse   534 TILSSDKETIEIIDLAKKDLEKLKRKEKKKKKRLQKLEESGREERSVAGKDDNADTDQEKKEEKG 598

  Fly   537 -----------IQNQNVSSEETEVA------------------SSDSEAEEVVK---DLEAIDND 569
                       .:||.||..|.|..                  .||||::|...   ||..|..:
Mouse   599 VSEKENNELDVEENQEVSDHEDEEEEEEDEEEEDDIEGEESSDESDSESDEKANYQADLANITCE 663

  Fly   570 IEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKV 634
            |.::.|||::||.:..|.:.::..|||||.:|..||.:||.|||.||.|: .||.:.|::..|||
Mouse   664 IAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNL-GSVESYSEEKAKKV 727

  Fly   635 KTDYESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSN 699
            |.:||.|:..|..|:::||.||:||.|..:....:|.::..|:.::.|:|..||:|||:|.::..
Mouse   728 KCEYEKKLHAMNKELQRLQTAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQE 792

  Fly   700 RHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQR-------GK 757
            :.:..|||:::|||||.|:||::.:.:..|||:...:|.:|:||||||.|||:..|       ||
Mouse   793 KARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGK 857

  Fly   758 -----SGQRAPAHLTSKIA-----------------------------TLDG------------- 775
                 |...:||..|...|                             |.:|             
Mouse   858 VTRKLSSSESPAPDTGSSAASGEADTSRPGTQQKMRIPVARVQALPTPTTNGTRKKYQRKGFTGR 922

  Fly   776 -FSTRSARHRWENLYRNILHAARNRQLITQLEKELERLILEREDLS---------RELNIMENGQ 830
             |::::||.:|:.|.|.:......:..|:.:|.::.||:.:||:|:         ||..:.|:|:
Mouse   923 VFTSKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLRQREELTKRREKLSKRREKIVKESGE 987

  Fly   831 TADRQTDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKF 895
            ......:...|:::|..||.||.::|...|..||:.|:.|:  :.....:.:::: ..|:.||::
Mouse   988 GDKSVANIIEEMESLTANIDYINDSIADCQANIMQMEEAKE--EGETLDVTAVIN-ACTLTEARY 1049

  Fly   896 ILQKFSDTAIVMSCNLAIAESHLQEKESLLKEVKQESGIQQQILQHFLSQNSNVHIADIFDSLNL 960
            :|..|....|......|..|:.::..|..||:.:..|..|.|:|.|.|.:.              
Mouse  1050 LLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEK-------------- 1100

  Fly   961 KGSNIASSVNPGSQKSLISNATYDI----PQDDKNSEFHQVEMRRTTSRSPSPLGNSDPFD---- 1017
                  :.:|| ...:|:.:|..|:    |:::::|......:     .||...|::...|    
Mouse  1101 ------AELNP-ELDALLGHALQDLDGAPPENEEDSSEEDGPL-----HSPGSEGSTLSSDLMKL 1153

  Fly  1018 -----KSPKVRRRTAKRQDLLFGD-TELSEQT 1043
                 ...|.||||..:.:||:.| :|::..|
Mouse  1154 CGEVKPKNKARRRTTTQMELLYADSSEVASDT 1185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp31ENP_001162935.1 KISc_KIF4 12..364 CDD:276823 228/365 (62%)
KISc 13..370 CDD:214526 233/371 (63%)
KASH_CCD 409..589 CDD:291334 66/257 (26%)
RasGAP <685..750 CDD:295371 28/64 (44%)
Kif21aXP_017171930.1 KISc_KIF4 23..380 CDD:276823 228/365 (62%)
Smc <389..787 CDD:224117 129/398 (32%)
SbcC <650..>1110 CDD:223496 138/484 (29%)
WD40 1350..1663 CDD:238121
WD40 repeat 1401..1460 CDD:293791
WD40 repeat 1466..1501 CDD:293791
WD40 repeat 1506..1550 CDD:293791
WD40 repeat 1558..1591 CDD:293791
WD40 repeat 1598..1634 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 425 1.000 Domainoid score I614
eggNOG 1 0.900 - - E2759_KOG0244
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56761
Inparanoid 1 1.050 697 1.000 Inparanoid score I674
Isobase 1 0.950 - 0 Normalized mean entropy S3133
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D390391at2759
OrthoFinder 1 1.000 - - FOG0002395
OrthoInspector 1 1.000 - - otm44325
orthoMCL 1 0.900 - - OOG6_100464
Panther 1 1.100 - - LDO PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5505
SonicParanoid 1 1.000 - - X2095
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.810

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