Protein Alignment Klp31E and sub

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_308782.4
• Gene: sub / 1270110
• VectorBaseID: AGAMI1_012903
• Length: 632
• Species: Anopheles gambiae
• Alignment Length: 677
• Identity: 173/677 - (25%)
• Similarity: 276/677 - (40%)
• Gaps: 190/677 - (28%)

  Fly     4 EVDSINKDS----SVRVAVRIRP-----------QNSRELIDMCRICTTVTLGEPQIFLGSDKAF 53
            |.|..|.:|    :|:|.:|:||           .....||..|.       ||.| ...|.|.:
Mosquito    66 EEDGANLESREEETVKVCLRLRPCTKTGGRMAFKIKDNVLIARCP-------GESQ-STASQKHY 122

  Fly    54 TFDYVFDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQL 118
            ||..||:.|.:|.::|..|:...:..||....||.|.||.:|||||||:         ..:....
Mosquito   123 TFSNVFEENVSQAEVYDCCIRPTIRPTLGEPGATFLTYGTSGSGKTYTL---------LGNETNP 178

  Fly   119 GIIPRAVRHIFSGI------------------------------------EQLEGSSTS------ 141
            ||:||::..|:..:                                    .:|:|...|
Mosquito   179 GIVPRSIEQIYEELYDNISTEPSLKMECMKPIPLSDESVLDELRKLRLIKSRLQGGEESRTVISD 243

  Fly   142 ----EH---PAAGGSPQFSLAVQYIELYNEDIFDLLD---PFNKNSNFKIHEDASGQITISGASI 196
                :|   |...|..:..:.:.::|:|||:::|||:   .:.|....|:..: .|...|.|.|.
Mosquito   244 TIQQQHQFEPLDMGDKRVFIWISFVEIYNENVYDLLNVEGDYGKRKAMKVLSN-DGNAYIKGLST 307

  Fly   197 KPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSK 261
            .......||...||.|..:.|..:|.:|..|||||::||:.|....:.|.         ....|.
Mosquito   308 LYAGTKEDAYALLQYGLQSATYGATDVNSNSSRSHSIFTVTVITHSMATQ---------RISQSV 363

  Fly   262 FHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSK-RALH--VPYRDSKLTRL 323
            :.|.|||||||||:|...|:|.:|...||..||.||.|:..:....| :.||  ||.||||||.:
Mosquito   364 YKFCDLAGSERLKKTGTVGDRLKEAQKINTSLLVLGRCLETVHKNQKTKKLHELVPVRDSKLTMI 428

  Fly   324 LQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNI---KNKVKINQDQSSRTISQLRREI 385
            :|.:|.|.....||..|.|::..:.|.||.|.:::.|:.|   |:...:....|:|....|.:.|
Mosquito   429 IQSALLGKEPMTMIVNVYPTEEFYDENLNVLNFSSIAKQIVISKHPKIMKAPHSTRYSFFLSQAI 493

  Fly   386 AALQLE------LLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQR 444
            ::...:      |:||:..||               ||..|::|.::....:..||..:|
Mosquito   494 SSPSAKVDTHRLLMEYESLKL---------------ENDRLVAEAEQKSAEIVCLQKKLA----- 538

  Fly   445 NADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIES-EEHRKQMEIKATTSPRNAKP 508
                                           ::..:|:.:|.:: ::|..:||....|..|:||
Mosquito   539 -------------------------------IQEFQLRNELTDNFQQHFAKMEESYETRIRSAK- 571

  Fly   509 VYDSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMR 573
                              ||::   ||  ....::|.|.::.|.    |:::.::|...:|.|.:
Mosquito   572 ------------------ELVV---LP--YKHQLASLENKLKSK----EQIIMEMEDEQDDYEKK 609

  Fly   574 TKLIEQLELTNSRYEQMRTHYEEKLSV 600
            .|..|: ||:..|.:|.|.   .:|||
Mosquito   610 LKAYEE-ELSKYRLQQSRV---RRLSV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	123/424 (29%)
		Mplasa_alph_rch	<372..>748	CDD:275316	46/236 (19%)
		SMC_prok_B	622..>899	CDD:274008
		Rcc_KIF21	798..870	CDD:410202
sub	XP_308782.4	Motor_domain	80..466	CDD:473979	120/412 (29%)
		SMC_N	<509..>623	CDD:481474	35/193 (18%)