DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp31E and kif21a

DIOPT Version :9

Sequence 1:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster
Sequence 2:	NP_001182593.1	Gene:	kif21a / 100485713	XenbaseID:	XB-GENE-1010599	Length:	1662	Species:	Xenopus tropicalis

Alignment Length:	1197	Identity:	472/1197 - (39%)
Similarity:	674/1197 - (56%)	Gaps:	217/1197 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSSVRVAVRIRPQNSRELIDMCRICTTVTLGEPQIFLGSDKAFTFDYVFDTNSNQCDIYSDCVEK 75
            ||:||||:|||||.::|.|:.|.|||:||.||||:.||.|||||||||||.:|.|.:||..|.||
Frog     7 DSAVRVALRIRPQLAKEKIEGCHICTSVTPGEPQVVLGKDKAFTFDYVFDIDSRQEEIYMQCTEK 71

  Fly    76 LVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSGIEQLEGSST 140
            |::....||||||.||||||:|||||||||||......:.   |||||||.|:|..||:.:..:.
Frog    72 LIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNISEEEH---GIIPRAVTHLFRRIEEKKQFAL 133

  Fly   141 SEHPAAGG--SPQFSLAVQYIELYNEDIFDL------LDPFNKNSNFKIHEDASGQITISGASIK 197
            .:     |  .|.|.:..|::|||||::.||      :|..||.||.:||||:||.|...|.:.:
Frog   134 EQ-----GLPPPDFKVNAQFLELYNEEVLDLFDTTRDIDARNKKSNIRIHEDSSGGIYTVGVTTR 193

  Fly   198 PIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPD---------- 252
            .:....:.::.|:.|||:||||||:||.|||||||:|||.:.:.|:....||..|
Frog   194 NVSSETEMIQCLKIGALSRTTASTQMNVQSSRSHAIFTIHLCQNRVCPKIDNENDLDNRMASESN 258

  Fly   253 --NDLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPY 315
              |:.||||:||||||||||||||||.||||||:||||||||||||||.|||||||||:|.||||
Frog   259 QINEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKKATHVPY 323

  Fly   316 RDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQ 380
            |||||||||||||||||||:||||||||||||||||||||||||||||||||.:|||::|:.|:.
Frog   324 RDSKLTRLLQDSLGGNSQTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRTSQQINA 388

  Fly   381 LRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRN 445
            ||.|||.||:||:|||.||.|:|.||..:|:|.|:||.:|.:|...|:.|:|::|.||..|..|.
Frog   389 LRNEIARLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETIDALRSRI 453

  Fly   446 ADL---KTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQM--EIKATTSPRN 505
            ..|   :.|..|::  |.|.:: ||:.::..|:.|||:|:.||:|||...:.:  .:...:|..:
Frog   454 TQLMSDQANQVLSR--SGDGNE-EISNMIHNYIKEIEDLRAKLLESEAVNENLRKSLSRASSRSS 515

  Fly   506 AKPVY-------------DSDIITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVA------- 550
            ..|.:             .::||..||||||:.:::...:....::.:|..:|:.|..
Frog   516 YFPAHTPFPTSLIAAEQETNEIIDMAKKDLEKLKKIEKKKKKSIVKEENPDNEKLEEKDNTEKEC 580

  Fly   551 ---------------------------------SSDSEAEE---VVKDLEAIDNDIEMRTKLIEQ 579
                                             .||||.||   ...||..|..:|.::.|||::
Frog   581 HDLVIEERSDHEEDEEEEEEEEDEDVDAAESSDDSDSELEEKENYQADLANITCEIAIKQKLIDE 645

  Fly   580 LELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTDYESKISH 644
            ||.:..|...::..|||||..|..||::||.|||.||.|| .|:.|.:::..||:|.:||.|:..
Frog   646 LENSQRRLHTLKQQYEEKLMTLQNKIKDTQLERDRVLQNM-GSMETCTEEKAKKIKVEYEKKLQT 709

  Fly   645 MQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQQSNRHKQEESRKS 709
            |..|::|||.||:||.|..:....:|.::..|:.|:.|:|..||:|||:|.::..:.:..|:|::
Frog   710 MNKELQKLQAAQKEHARLLKNQSQYEKQMKKLQQEVVEMKKTKVRLMKQMKEEQEKARVTETRRN 774

  Fly   710 KEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQR-------GKSGQR------ 761
            :|||||.|:||::.:.:..|||:...:|.:|:||||||.|||:..|       |:.|::
Frog   775 REIAQLKKDQRKRDSQLRLLEAQKKQQEVVLRRKTEEVTALRRQVRPMSDRVAGRVGRKISLPEP 839

  Fly   762 ------------------------------APAHLTSKIAT--------LDGFSTRSARHRWENL 788
                                          .||..|:...|        :..:::::||.:|::|
Frog   840 IAEHISNMPEELDSTKHGLQQKPRIPVARVQPATSTALNGTRKKYQRKGVSSYTSKAARQKWQSL 904

  Fly   789 YRNILHAARNRQLITQLEKELERLILEREDLS---------RELNIMENGQTADRQTDEFN-EVD 843
            .|.|......|..|:.:|.::.||:.:||:|:         |:..:.|:|. ||:.....: |::
Frog   905 ERRITDIVMQRMTISNMEVDMNRLLKQREELTKRKEKVSKKRDRILKESGD-ADKNIHSLSEEME 968

  Fly   844 NLKTNISYIQENIEHVQQAIMEFEDTK---DTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAI 905
            :|..||.|:.::|...|.:||:.|:.|   ||:.     :.:::.. .|:.||:::|..|.:.|:
Frog   969 SLNANIDYLNDSISDCQASIMQMEEAKEEGDTLD-----VTAVISS-CTLTEARYLLDHFLNMAV 1027

  Fly   906 VMSCNLAIAESHLQEKESLLKEVKQESGIQQQILQHFLSQNSNV---------HIADIFDSLNLK 961
            ..|...|..|:.::..|..||:.:..|..|.|:|.|.|.:.:.:         |.....||:.|:
Frog  1028 SKSLQAAQREAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSIPLE 1092

  Fly   962 GSNIASSVNPGSQKSLISNATYDIPQDDKNSEFHQVEMRRTTSRSPSPLGNSDPFD--------- 1017
            .:..:|                    ||..|           .:|||..|.|...|
Frog  1093 NAENSS--------------------DDDGS-----------LQSPSTEGGSLTSDLMKLCGEVK 1126

  Fly  1018 -KSPKVRRRTAKRQDLLFGDTELSEQT 1043
             || |.||||..:.:||:.|:  ||.|
Frog  1127 PKS-KARRRTTTQLELLYADS--SEST 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	228/371 (61%)
		KISc	13..370	CDD:214526	232/376 (62%)
		KASH_CCD	409..589	CDD:291334	61/240 (25%)
		RasGAP	<685..750	CDD:295371	27/64 (42%)
kif21a	NP_001182593.1	KISc_KIF4	8..372	CDD:276823	228/371 (61%)
		KISc	9..378	CDD:214526	232/376 (62%)
		GBP_C	<640..784	CDD:303769	60/144 (42%)
		Rabaptin	666..1130	CDD:281520	138/503 (27%)
		coiled coil	759..769	CDD:293879	1/9 (11%)
		WD40	<1320..1645	CDD:225201
		WD40	1327..1640	CDD:238121
		WD40 repeat	1339..1373	CDD:293791
		WD40 repeat	1378..1415	CDD:293791
		WD40 repeat	1443..1478	CDD:293791
		WD40 repeat	1483..1527	CDD:293791
		WD40 repeat	1535..1568	CDD:293791
		WD40 repeat	1575..1611	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I623
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56761
Inparanoid	1	1.050	727	1.000	Inparanoid score	I617
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390391at2759
OrthoFinder	1	1.000	-	-		FOG0002395
OrthoInspector	1	1.000	-	-		otm49501
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5505
SonicParanoid	1	1.000	-	-		X2095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090