Protein Alignment Klp31E and kif20bb

DIOPT Version :10

• Sequence 1: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Sequence 2: XP_073774416.1
• Gene: kif20bb / 100007502
• ZFINID: ZDB-GENE-030131-9684
• Length: 1547
• Species: Danio rerio
• Alignment Length: 1454
• Identity: 311/1454 - (21%)
• Similarity: 555/1454 - (38%)
• Gaps: 472/1454 - (32%)

  Fly     1 MISEVDSINKDS------SVRVAVRIRPQNSRELID-MCRICTTVTLGEP--QIFLGSDKA---- 52
            :.||...:::||      .::|.:|:||..|.|..: ..:.|.::   ||  .:.|.:.||
Zfish    25 LFSEFSKLSRDSVSLEKEHLQVYLRVRPFTSTERAEGESQDCISI---EPPDTVILKAPKASLTA 86

  Fly    53 -------------FTFDYVFDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGT 104
                         |.|..|:...:.|.:|:....:.||...|.|.|:.:..||.|.:|||:|.
Zfish    87 RHSERFGPQLAQRFQFSQVYGPETTQKEIFDGTTKSLVKEVLDGGNSLIFTYGVTNAGKTFTF-- 149

  Fly   105 GFDHESESSDSVQLGIIPRAVRHIFSGIE------------------------------------ 133
             ...||:.      ||:||::..||:.||
Zfish   150 -LGPESDG------GILPRSLNVIFNSIEGRIYLQNNIKPHRCVDFTRLTKEQQDEEATNKRNLL 207

  Fly   134 -------------QLEGSSTSEHPAAGGSP--------------QFSLAVQYIELYNEDIFDLLD 171
                         .:..||.|...::..|.              :||:.|.:.|:|||.|.||||
Zfish   208 RRFKDNDSQKTLSSMSSSSCSSFDSSTSSDMNGDSVYLDEDSHVKFSVWVSFCEIYNESIHDLLD 272

  Fly   172 PFNKNSN-----FKIHEDASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSH 231
             |..|.:     .::.:|......:.......:....:|||.::.|...::.:|||:|:.|||||
Zfish   273 -FVPNGSHRRNALRLAQDVKSNSFVKDLKWVQVNSADEALKVVKIGRKNQSFSSTKLNNISSRSH 336

  Fly   232 ALFTIFVRRQRLLTPSD-NVPDNDLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLA 295
            ::|:|     |:|...| .||  .::|: |:....|||||||..|||..|||.:|..:||..||.
Zfish   337 SIFSI-----RMLRIEDVGVP--RVQTI-SELSLCDLAGSERCARTQNRGERLKEAGNINTSLLT 393

  Fly   296 LGNCISAL---GDKSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYA 357
            ||.||:||   ..:||...|:|:|:||||..||....|..:..||..::.....:.||||.||::
Zfish   394 LGKCINALRLNQTQSKFHQHIPFRESKLTHYLQGYFCGRGKACMIININQCASVYDETLNVLKFS 458

  Fly   358 --------------------NRARNIK------------------------------------NK 366
                                ..||::.                                    ::
Zfish   459 AVAQKVVVLNPKPAPSIALKRSARDVSMIINNADKKDWTRRSSIMGWEMSLEDVQEDENDEDMDE 523

  Fly   367 VKINQDQSS---RTI---------SQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKL 419
            .::..|..|   ||:         .:|:.:|..||.:|::.:..||.::......::..|.|
Zfish   524 EEVESDDESIVDRTVLETVENQELCELQVKIEELQEKLIKEESEKLTLEARIREEVTTEFME--- 585

  Fly   420 LLSEI-KRLQQRLKSLQSTIATLTQRNADLKTNL---DLNKWTSDDNSDVE-------------- 466
            |.|.: |...:||:..:..:....:|..::..||   .:.:.|:|:|:..|
Zfish   586 LFSNMEKDYSERLQREKEIVEERAERRLEILKNLVNRTIEEMTTDENAAKEAKMELLDTMIEAMR 650

  Fly   467 --IAKVVG-----QYML---------------EIEELQTKLIESEEHRKQMEIKATTSPRNAKPV 509
              :.|:.|     |..|               |:||::.:|::|::   |:.:|:.....:...:
Zfish   651 SDLTKIKGDAESVQLCLANVPESPGKLSHLRTELEEIKAELLKSQQ---QLSLKSKEFEESCIQM 712

  Fly   510 YD-SDIITKAKKDLERER----ELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDND 569
            .| :|.:.:|.::.|.::    ||:   |:...::..||..:|.:..:|..|.   ||...|:|.
Zfish   713 QDLNDQLLQATRNYENQKVRCQELM---SICQEKDDMVSKLQTALEQNDEAAS---KDRALINNI 771

  Fly   570 IE--------MRTKLIEQL-ELTNSRYEQMRTHYEEK------LSVLYCKIENTQKERDDVLANM 619
            .|        .:.||.|:. |:|:.:.:|::...:.|      |.:.:..:|...::..|.|:.:
Zfish   772 REEILHFKNSCKCKLNEEHDEMTSQKNQQLQQELKMKDDQLNQLKLEHASLEKAMRDISDRLSEL 836

  Fly   620 T--------------TSVSTPSK------DSLKKVKTDYESKISHMQTEI-----------RKLQ 653
            |              ..|:..:|      |.|::...:..||:..:|||:           .:|.
Zfish   837 TQTHEATVAMERAEVNKVTNENKALANELDELQQRANEMSSKVETIQTELGNQSKKANELSEELH 901

  Fly   654 NAQ---REH----IRSKQQLKSHEVRIGTLRNELN------ELKFAKVKLMKKMSQQSNRH---- 701
            .|:   |||    ....|.::|..:....||.||:      :.|.|:.:.|..:||:.||.
Zfish   902 TARALIREHQEESCSHSQTIESLMIEAAHLRLELSTCQLSRDRKEAECERMVALSQEKNRQISDL 966

  Fly   702 KQE--ESRKS----KEIAQLLKEQR--------------RQKNAVLTLEAKVSAKEQILKRKTEE 746
            :||  ::|:|    :|:...||.:|              ..:|.|:|   ::.:...:|    ||
Zfish   967 EQELKQTRESVCQLEELCSRLKSERDAQAQEYQSLLNRYEAQNLVVT---QIRSNSDLL----EE 1024

  Fly   747 VIALRKSQRGKSGQRAPAHLTSKIATLDG---------FSTRSARHRWE-------NLYRNILHA 795
            :.||:             |...||...|.         ..|.|..::.|       .:..|.:..
Zfish  1025 LTALK-------------HQHKKIEKQDDCWKTVQDNLIQTVSKLNQQEEILSIVQTIVTNEISK 1076

  Fly   796 ARN--RQLITQLEKELERLILEREDLSRELNIM-----------------------ENGQTADRQ 835
            ||:  ...||::||:|.....|.|..::||..:                       |.....|:.
Zfish  1077 ARDEANMKITEMEKDLSNKNTELETKAQELMKVREHVNDGHNQIERMRCDLQQVEQERSDVRDQL 1141

  Fly   836 TDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQK- 899
            .:...:.::|:..|..:.|..:..||.:.|.|..||..:..::.|:..:|.:. :.::..:|:|
Zfish  1142 CEANTQKEHLEKQILILSEESKMFQQRLCEAEKMKDQPRPCLSCIEQTIDPLQ-IEQSNHVLEKE 1205

  Fly   900 --------------FSDTAIVMSCNLAIAESHLQEKESLLK----EV------------------ 928
                          ..:|.:.::     .|....::|.|||    |:
Zfish  1206 DIQLFQTPCQESKLIEETPVTLN-----TEFKRTDEEELLKPRLTEIEFITEDLATLQEKNQNPR 1265

  Fly   929 -------KQESGIQQQILQH-------------------FLSQNSNVHIAD-IFDSLNLKGSNIA 966
                   :||.|..|:..:|                   .:|.||:...|| :..:.|:|..|..
Zfish  1266 VGVSDHSQQEDGRAQRPEEHTRQQLVKKQDTILKLQKDSVVSPNSDTQEADKLKQTSNMKTKNEG 1330

  Fly   967 SSVNPGSQK------SLISNATY---DIPQDDKNSEFHQVEMRRTTSRSPSPLGNSDPFDKSPKV 1022
            .||:|..::      |::|..:.   ..|:.:....|..::..|...|.|   |..:  ..:.|:
Zfish  1331 DSVSPTQEQVAEQDSSVLSTKSLREERFPKPELEISFTPLKPHRMNVRKP---GEEE--SVTIKL 1390

  Fly  1023 RRRTAKRQDLLFGDTELSEQTFNK 1046
            ||...||:.....::..||...|:
Zfish  1391 RRTARKRKSTEIENSVESENCKNR 1414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	127/469 (27%)
		Mplasa_alph_rch	<372..>748	CDD:275316	106/515 (21%)
		SMC_prok_B	622..>899	CDD:274008	76/371 (20%)
		Rcc_KIF21	798..870	CDD:410202	18/96 (19%)
kif20bb	XP_073774416.1	None