Protein Alignment CG5355 and PREPL

DIOPT Version :10

• Sequence 1: NP_609397.2
• Gene: CG5355 / 34421
• FlyBaseID: FBgn0032242
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_006027.2
• Gene: PREPL / 9581
• HGNCID: 30228
• Length: 727
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 172/778 - (22%)
• Similarity: 304/778 - (39%)
• Gaps: 174/778 - (22%)

  Fly    34 SNLTRAMPS-TLSAKLAYPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPF 97
            |.|.|.:|| :.|.|...||.:::|                                     :|.
Human    59 SELARNIPSRSFSCKDLQPVKQENE-------------------------------------KPL 86

  Fly    98 LENGEEWKKLNTKL--TKLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQK-SLGDESESKVF 159
            .||.:.::|:.|||  .....|......:::|.:.||      |....:.:.| ...|....:|.
Human    87 PENMDAFEKVRTKLETQPQEEYEIINVEVKHGGFVYY------QEGCCLVRSKDEEADNDNYEVL 145

  Fly   160 LDPNTLSEDGTIALTQKAF------SEDGKYMAYGLSESGSDWIKILIRDAETG-----KDLSEV 213
            .:...|..|       :.|      :.|.||:|          .||...|:|..     |...:.
Human   146 FNLEELKLD-------QPFIDCIRVAPDEKYVA----------AKIRTEDSEASTCVIIKLSDQP 193

  Fly   214 LEKVKFSEIS---WTKDNKG---FFYG-----RYPDQDGKTDGSETKQNENQKLYYHRVGESQDK 267
            :.:..|..:|   |.||.:.   .||.     |..|....|.| :.|:||.   :|      .:|
Human   194 VMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFG-DNKRNER---FY------TEK 248

  Fly   268 DTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRDNIVFYADLTPGAEITSKLNVKKIVEK-FE 331
            |         ||:.:...::...::|.:.|:......:.....|:|       .:...:::| ..
Human   249 D---------PSYFVFLYLTKDSRFLTINIMNKTTSEVWLIDGLSP-------WDPPVLIQKRIH 297

  Fly   332 ADYDYITNEGSKIFFRTNKNAP-NYQVIAIDFNNSAEDKWETLIAEHKSDVLDWVKCVDNDKL-- 393
            ....|:.:...:::..||...| .::::....:..|...|:......::     .|.:|.|..
Human   298 GVLYYVEHRDDELYILTNVGEPTEFKLMRTAADTPAIMNWDLFFTMKRN-----TKVIDLDMFKD 357

  Fly   394 -LVCYIRDVKSVLQVN--SLKDGTLLREFDLD---IGTIVGTSGEKKYSEIFYNFSSFLNPGSIY 452
             .|.:::. .::|.||  .|.|.: :|...|.   .|.|:.|:.:.|...  :...|.:.|...|
Human   358 HCVLFLKH-SNLLYVNVIGLADDS-VRSLKLPPWACGFIMDTNSDPKNCP--FQLCSPIRPPKYY 418

  Fly   453 RYDF-------KTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFIIRK-KRDSVE 509
            .|.|       :|..:.|.......|.||.             |||||..|||.:..| ..:.::
Human   419 TYKFAEGKLFEETGHEDPITKTSRVLRLEA-------------KSKDGKLVPMTVFHKTDSEDLQ 470

  Fly   510 PRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDG-VLAYPNLRGGGEYGEKWHNGGRLLNKQNVFD 573
            .:|.|::.||.:.:.:..:|.....:.:|  || :|||.::|||||.|.:||..|||..|.|...
Human   471 KKPLLVHVYGAYGMDLKMNFRPERRVLVD--DGWILAYCHVRGGGELGLQWHADGRLTKKLNGLA 533

  Fly   574 DFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDMLRFHKFT--- 635
            |.:|..:.|....::......:...|.||:|.|:..|..|:|..|...:...:|:|.....|
Human   534 DLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLP 598

  Fly   636 IGHAWCSDYGNP-SEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHSL-KFI 698
            :......::||| |:::|.:.:.::.|..|: .|:    .|||..|...::|:|| ||..: .:.
Human   599 LTLEELEEWGNPSSDEKHKNYIKRYCPYQNI-KPQ----HYPSIHITAYENDERV-PLKGIVSYT 657

  Fly   699 AALQEAVRD-----SEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNVDIVNV 756
            ..|:||:.:     .|..:.|.::...|..|:...:.:.|:|   |..:.||.:.|.:|..:|
Human   658 EKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKI---TAQIKFLYEELGLDSTSV 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	PreP	45..749	CDD:441114	164/757 (22%)
PREPL	NP_006027.2	PtrB	113..649	CDD:441376	137/614 (22%)