Protein Alignment CG5355 and PREP

DIOPT Version :10

• Sequence 1: NP_609397.2
• Gene: CG5355 / 34421
• FlyBaseID: FBgn0032242
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_002717.3
• Gene: PREP / 5550
• HGNCID: 9358
• Length: 710
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 388/708 - (54%)
• Similarity: 502/708 - (70%)
• Gaps: 7/708 - (0%)

  Fly    48 LAYPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLENGEEWKKLNTKLT 112
            |.||...:||:..:|:||.:|.|.|.|||||||.:|:.||.|||.|:.||||..........::|
Human     4 LQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMT 68

  Fly   113 KLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLDPNTLSEDGTIALTQKA 177
            :|::||||.|..:.|..|:||.|||||||.|:|.|.||  |.|::||||||.||:|||:||...|
Human    69 ELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSL--EGEARVFLDPNILSDDGTVALRGYA 131

  Fly   178 FSEDGKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGK 242
            |||||:|.|||||.|||||:.|.....:..|:|.:|||:||||.::||.|.||.||..||.||||
Human   132 FSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGK 196

  Fly   243 TDGSETKQNENQKLYYHRVGESQDKDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRD-NIV 306
            :||:||..|.:||||||.:|..|.:|.|..|||:||.|...:.:||.|:|::|:|.:.|.. |.:
Human   197 SDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRL 261

  Fly   307 FYADL-TPGAEITSKLNVKKIVEKFEADYDYITNEGSKIFFRTNKNAPNYQVIAIDFNNSAEDKW 370
            :|.|| ...:.|...|...|:::.||.:|||:||||:...|:||:.:|||:||.|||.:..|.||
Human   262 WYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKW 326

  Fly   371 ETLIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGTLLREFDLDIGTIVGTSGEKKY 435
            :.|:.||:.|||:|:.||.::.|::||:.|||::||::.|..|.||:.|.||:|:|||.||:||.
Human   327 KVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKD 391

  Fly   436 SEIFYNFSSFLNPGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFI 500
            :||||.|:|||:||.||..|....:..|.||||:  .::|....||...||||.||||||:||||
Human   392 TEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREV--TVKGIDASDYQTVQIFYPSKDGTKIPMFI 454

  Fly   501 IRKKRDSVE-PRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYPNLRGGGEYGEKWHNGGR 564
            :.||...:: ..|..||||||||||:.|::.:|.|:|:....|:||..|:||||||||.||.||.
Human   455 VHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGI 519

  Fly   565 LLNKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDML 629
            |.||||.|||||.||||||:..||:..||.|.|||||||||.:|.||||||||..:|||||||||
Human   520 LANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDML 584

  Fly   630 RFHKFTIGHAWCSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHS 694
            :|||:||||||.:|||....|:||:.|.|:||||||..|:..:.:|||.|:|||||||||.||||
Human   585 KFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHS 649

  Fly   695 LKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNVD 752
            |||||.||..|..|..|.||:|:.|..||||||||||:|.|||.:|:..|:::.||||
Human   650 LKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVD 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	PreP	45..749	CDD:441114	384/703 (55%)
PREP	NP_002717.3	PreP	4..704	CDD:441114	384/703 (55%)