DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5355 and PREP

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_002717.3	Gene:	PREP / 5550	HGNCID:	9358	Length:	710	Species:	Homo sapiens

Alignment Length:	708	Identity:	388/708 - (54%)
Similarity:	502/708 - (70%)	Gaps:	7/708 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LAYPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLENGEEWKKLNTKLT 112
            |.||...:||:..:|:||.:|.|.|.|||||||.:|:.||.|||.|:.||||..........::|
Human     4 LQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMT 68

  Fly   113 KLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLDPNTLSEDGTIALTQKA 177
            :|::||||.|..:.|..|:||.|||||||.|:|.|.||  |.|::||||||.||:|||:||...|
Human    69 ELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSL--EGEARVFLDPNILSDDGTVALRGYA 131

  Fly   178 FSEDGKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGK 242
            |||||:|.|||||.|||||:.|.....:..|:|.:|||:||||.::||.|.||.||..||.||||
Human   132 FSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGK 196

  Fly   243 TDGSETKQNENQKLYYHRVGESQDKDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRD-NIV 306
            :||:||..|.:||||||.:|..|.:|.|..|||:||.|...:.:||.|:|::|:|.:.|.. |.:
Human   197 SDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRL 261

  Fly   307 FYADL-TPGAEITSKLNVKKIVEKFEADYDYITNEGSKIFFRTNKNAPNYQVIAIDFNNSAEDKW 370
            :|.|| ...:.|...|...|:::.||.:|||:||||:...|:||:.:|||:||.|||.:..|.||
Human   262 WYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKW 326

  Fly   371 ETLIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGTLLREFDLDIGTIVGTSGEKKY 435
            :.|:.||:.|||:|:.||.::.|::||:.|||::||::.|..|.||:.|.||:|:|||.||:||.
Human   327 KVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKD 391

  Fly   436 SEIFYNFSSFLNPGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFI 500
            :||||.|:|||:||.||..|....:..|.||||:  .::|....||...||||.||||||:||||
Human   392 TEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREV--TVKGIDASDYQTVQIFYPSKDGTKIPMFI 454

  Fly   501 IRKKRDSVE-PRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYPNLRGGGEYGEKWHNGGR 564
            :.||...:: ..|..||||||||||:.|::.:|.|:|:....|:||..|:||||||||.||.||.
Human   455 VHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGI 519

  Fly   565 LLNKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDML 629
            |.||||.|||||.||||||:..||:..||.|.|||||||||.:|.||||||||..:|||||||||
Human   520 LANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDML 584

  Fly   630 RFHKFTIGHAWCSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHS 694
            :|||:||||||.:|||....|:||:.|.|:||||||..|:..:.:|||.|:|||||||||.||||
Human   585 KFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHS 649

  Fly   695 LKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNVD 752
            |||||.||..|..|..|.||:|:.|..||||||||||:|.|||.:|:..|:::.||||
Human   650 LKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVD 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	210/417 (50%)
		Aes	442..750	CDD:223730	183/308 (59%)
		Peptidase_S9	541..752	CDD:278741	137/210 (65%)
PREP	NP_002717.3	PreP	26..704	CDD:224422	375/681 (55%)
PREP	NP_002717.3	Peptidase_S9	482..707	CDD:278741	141/224 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158396
Domainoid	1	1.000	436	1.000	Domainoid score	I572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2042
Inparanoid	1	1.050	799	1.000	Inparanoid score	I513
Isobase	1	0.950	-	0	Normalized mean entropy	S5334
OMA	1	1.010	-	-		QHG63012
OrthoDB	1	1.010	-	-		D217404at33208
OrthoFinder	1	1.000	-	-		FOG0005219
OrthoInspector	1	1.000	-	-		otm41277
orthoMCL	1	0.900	-	-		OOG6_101804
Panther	1	1.100	-	-	LDO	PTHR42881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4346
SonicParanoid	1	1.000	-	-		X3731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890