DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5355 and prep

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001018589.1	Gene:	prep / 553791	ZFINID:	ZDB-GENE-050522-14	Length:	709	Species:	Danio rerio

Alignment Length:	705	Identity:	372/705 - (52%)
Similarity:	489/705 - (69%)	Gaps:	7/705 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 YPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLENGEEWKKLNTKLTKL 114
            ||...:||||.:|:||.:|.|.|.|||||||.:|:.||||||.::.||||..|.......::|:|
Zfish     5 YPNVYRDESVVDDYHGCKIPDPYSWLEDPDSEKTQAFVNAQNQLTLPFLEQCETRDLFKERMTEL 69

  Fly   115 WNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLDPNTLSEDGTIALTQKAFS 179
            ::||||.||.:.|:.|::|.|||||||||||.|.:|  ::|..|||||||.|||||:||...:||
Zfish    70 YDYPKYSCPFKRGDRYFHFYNTGLQNQSVMYVQDNL--DAEPTVFLDPNTFSEDGTVALRGYSFS 132

  Fly   180 EDGKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGKTD 244
            |||:::|||.|.|||||::|.....:....|.:.||:|||:.:|||.|.||.||..||:|:||:|
Zfish   133 EDGEFLAYGTSASGSDWVEIRFLRVDGAVLLEDRLERVKFTCMSWTHDGKGLFYNSYPEQEGKSD 197

  Fly   245 GSETKQNENQKLYYHRVGESQDKDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVKDCRD-NIVFY 308
            |:||..|.:||||||.:|..|.:|.|..|||:||.|.....|||.|:|::|:|.:.|.. |.::|
Zfish   198 GTETSTNLHQKLYYHVLGTPQSQDVLCAEFPDEPKWMSGVEVSDDGRYVLLSIREGCDPVNRLWY 262

  Fly   309 ADLTPGAE-ITSKLNVKKIVEKFEADYDYITNEGSKIFFRTNKNAPNYQVIAIDFNNSAEDKWET 372
            .||....: ||..|...|:::.|:|:|:|:||||:...|:||..||.|::|.|||...:..:|:.
Zfish   263 CDLNEEPQGITGLLPWVKLIDNFDAEYEYVTNEGTVFTFKTNLEAPQYRLINIDFTQPSVSQWKE 327

  Fly   373 LIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGTLLREFDLDIGTIVGTSGEKKYSE 437
            ||.:|..||:.:..|..:..|.||::.|||:||::..|..|..:|.|.||:|:|||.:|.||.||
Zfish   328 LIPQHDKDVIVFATCTFSSFLFVCFLHDVKNVLKMFHLSSGEEIRTFPLDVGSIVGFTGRKKDSE 392

  Fly   438 IFYNFSSFLNPGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFIIR 502
            |||:|:|||:|..||..|.......|.||||:  .::||...||...|:||.|||||::||||:.
Zfish   393 IFYSFTSFLSPAIIYHCDLTMEPLQPHVFREV--TVKGFNPADYQTTQVFYPSKDGTQIPMFIVH 455

  Fly   503 KKRDSVE-PRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYPNLRGGGEYGEKWHNGGRLL 566
            ||...:: ..|..||||||||||:.||:.:|.|:||....||||..|:||||||||.||.||.|.
Zfish   456 KKGIKMDGSHPAFLYGYGGFNISITPSYSVSRLIFIRHLGGVLAVANIRGGGEYGETWHKGGMLA 520

  Fly   567 NKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQVGVMDMLRF 631
            ||||.|.|||.||||||:..||:..:|.|.|||||||||.:|:||||||||.|||||||||||:|
Zfish   521 NKQNCFTDFQCAAEYLIKEGYTSPKKLTINGGSNGGLLVAACVNQRPDLFGCAVAQVGVMDMLKF 585

  Fly   632 HKFTIGHAWCSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDDRVSPLHSLK 696
            |||||||||.:|:|....||.||.|.|:|||||:..|:|...:||:.|:||.||||||.||||||
Zfish   586 HKFTIGHAWTTDFGCSEIKEQFDWLIKYSPLHNIQVPEGDGVQYPAVLLLTGDHDDRVVPLHSLK 650

  Fly   697 FIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNV 751
            :||.||..:.....||||:.:.:..|:||||||||||.|:|..|...|:::.||:
Zfish   651 YIATLQNVIGQCPGQKNPLFIYIDTKSGHGAGKPTSKVIQEVADTYAFIARCLNL 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	201/417 (48%)
		Aes	442..750	CDD:223730	178/308 (58%)
		Peptidase_S9	541..752	CDD:278741	132/211 (63%)
prep	NP_001018589.1	PreP	24..703	CDD:224422	360/682 (53%)
prep	NP_001018589.1	Peptidase_S9	481..706	CDD:278741	138/225 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594335
Domainoid	1	1.000	408	1.000	Domainoid score	I668
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2042
Inparanoid	1	1.050	762	1.000	Inparanoid score	I530
OMA	1	1.010	-	-		QHG63012
OrthoDB	1	1.010	-	-		D217404at33208
OrthoFinder	1	1.000	-	-		FOG0005219
OrthoInspector	1	1.000	-	-		otm25859
orthoMCL	1	0.900	-	-		OOG6_101804
Panther	1	1.100	-	-	LDO	PTHR42881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4346
SonicParanoid	1	1.000	-	-		X3731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940