DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5355 and prep

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_989189.1	Gene:	prep / 394797	XenbaseID:	XB-GENE-954889	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	714	Identity:	384/714 - (53%)
Similarity:	503/714 - (70%)	Gaps:	8/714 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 MPSTLSAKLAYPVARKDESVAEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLENGEEW 104
            ||.  ..|:.||.|.:|:...:::||.::.|.|||||||||.:|:.||.|||.::.||||.....
Frog     1 MPQ--QQKIQYPAAARDDCAVDNYHGVKMCDPYRWLEDPDSEQTKAFVEAQNKLTMPFLEKCPVR 63

  Fly   105 KKLNTKLTKLWNYPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLDPNTLSEDG 169
            :....::|:|::||||.|..:.||.|:||.|:|||||.|:|.|.||.|  |.||||||||.||||
Frog    64 RLFKDRMTELYDYPKYSCNFKKGNRYFYFYNSGLQNQRVLYVQDSLKD--EPKVFLDPNTFSEDG 126

  Fly   170 TIALTQKAFSEDGKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYG 234
            |:||...||||||:|.|||||.|||||:.|........::|.:|||:||||.:|||.|..|.||.
Frog   127 TVALQGYAFSEDGEYFAYGLSASGSDWVTIKFMKVANQEELPDVLERVKFSCMSWTHDGVGIFYN 191

  Fly   235 RYPDQDGKTDGSETKQNENQKLYYHRVGESQDKDTLVVEFPEEPSWRIQSTVSDCGKYLILAIVK 299
            .||.|.||:||:||..|.||||:||.:|.||..|.|..||||||.|...:.|:|.|:|::|:|.:
Frog   192 CYPQQKGKSDGTETSTNLNQKLFYHVLGTSQSDDVLCAEFPEEPKWMGGAEVTDDGQYVLLSIRE 256

  Fly   300 DCRD-NIVFYADLTPGAEITSKLNVKKIVEKFEADYDYITNEGSKIFFRTNKNAPNYQVIAIDFN 363
            .|.. |.::|..|.....||..|...|:::.|:|:|:||||||:...|:||:|||||::|.||||
Frog   257 GCDPVNRLWYCKLDKNTGITGILPWVKLIDNFDAEYEYITNEGTVFTFKTNRNAPNYKLINIDFN 321

  Fly   364 NSAEDKWETLIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGTLLREFDLDIGTIVG 428
            |..|..|:.|:.||:.|||:||.||....|::|.:.|||:|||::.|..|:.|:.|.||:|::||
Frog   322 NPEESNWKVLVPEHEKDVLEWVSCVHKKYLVLCCLHDVKNVLQLHDLASGSHLKTFPLDVGSVVG 386

  Fly   429 TSGEKKYSEIFYNFSSFLNPGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDG 493
            .||:||.|||||.|:|||:||.|:..|....:..|:||||:  :::||...||...|:||.||||
Frog   387 YSGQKKDSEIFYQFTSFLSPGIIFHCDLTKEELKPTVFREV--SVKGFDPSDYQTVQVFYPSKDG 449

  Fly   494 TKVPMFIIRKKRDSVE-PRPCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYPNLRGGGEYGE 557
            |.:||||:.||..::: ..|..||||||||||:.||:.:|.|:|:....|:||..|:||||||||
Frog   450 TMIPMFIVHKKGITLDKSHPAFLYGYGGFNISITPSYSVSRLIFVRHLGGILAVANIRGGGEYGE 514

  Fly   558 KWHNGGRLLNKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSCINQRPDLFGAAVAQ 622
            .||..|.|.||||.|||||.|||||::..|.:.:::.|.|||||||||.:|.||||:|||.|:||
Frog   515 TWHKAGILGNKQNCFDDFQCAAEYLVKEGYASAEKITINGGSNGGLLVAACANQRPELFGCAIAQ 579

  Fly   623 VGVMDMLRFHKFTIGHAWCSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLILTADHDD 687
            |||||||:||||||||||.:|||....||||:.|.|:|||||:..|:....:|||.|:|||||||
Frog   580 VGVMDMLKFHKFTIGHAWTTDYGCSDNKEHFEWLIKYSPLHNIKVPEKDGIQYPSMLLLTADHDD 644

  Fly   688 RVSPLHSLKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKPTSKRIEEATDILTFLSKSLNV 751
            ||.|||||||||:||.....|..|.||:|:.|..||||||||||:|.|||.:|:..|:::.||:
Frog   645 RVVPLHSLKFIASLQHIAGQSPNQTNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIAQCLNL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	211/416 (51%)
		Aes	442..750	CDD:223730	177/308 (57%)
		Peptidase_S9	541..752	CDD:278741	132/211 (63%)
prep	NP_989189.1	PreP	29..706	CDD:224422	373/680 (55%)
prep	NP_989189.1	Peptidase_S9	484..709	CDD:278741	137/225 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I554
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2042
Inparanoid	1	1.050	795	1.000	Inparanoid score	I499
OMA	1	1.010	-	-		QHG63012
OrthoDB	1	1.010	-	-		D217404at33208
OrthoFinder	1	1.000	-	-		FOG0005219
OrthoInspector	1	1.000	-	-		otm48483
Panther	1	1.100	-	-	LDO	PTHR42881
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080