DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5355 and APEH

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	XP_024309267.1	Gene:	APEH / 327	HGNCID:	586	Length:	804	Species:	Homo sapiens

Alignment Length:	801	Identity:	165/801 - (20%)
Similarity:	285/801 - (35%)	Gaps:	209/801 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AMPSTLSAKLAYPVARKDESV----AEDFHGTQIKDVYRWLEDPDSTETEEFVNAQNSISRPFLE 99
            ::|...:.:||....|:..:|    .|...|| :|.|.|........|.::|:
Human   115 SLPGASTPRLAPAAERRLWNVRLLSRESPSGT-MKAVLRKAGGTGPGEEKQFL------------ 166

  Fly   100 NGEEWKKLNTKLTKLWN---YPKYGCPMRYGNYYYYFMNTGLQNQSVMYQQKSLGDESESKVFLD 161
              |.|:| |.|| |.:|   ..|:| |: |.:..:..::.......::|..:....::||  |..
Human   167 --EVWEK-NRKL-KSFNLSALEKHG-PV-YEDDCFGCLSWSHSETHLLYVAEKKRPKAES--FFQ 223

  Fly   162 PNTL---SEDGTIALTQK----------AFSED-GKYMAYGLSESGSDWIKIL-IRDAETG--KD 209
            ...|   :.|..||..:|          .|.|| |:.|   :|:|    |.:| :.|.|:|  ..
Human   224 TKALDVSASDDEIARLKKPDQAIKGDQFVFYEDWGENM---VSKS----IPVLCVLDVESGNISV 281

  Fly   210 LSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGKTDGSETKQNENQKLYY-HRVG---ESQDKDTL 270
            |..|.|.|...:..|...:.|..:..:..:..:. |.....|....||| ..:|   |....|:|
Human   282 LEGVPENVSPGQAFWAPGDAGVVFVGWWHEPFRL-GIRFCTNRRSALYYVDLIGGKCELLSDDSL 345

  Fly   271 VVEFPE-EPSWRIQSTVSDCGKYLILAIVKDCRDNIVFYADLTPGAEITSKLNVKKIVEKFEADY 334
            .|..|. .|.                    .||...:.|..|.|..: .|:|.:          |
Human   346 AVSSPRLSPD--------------------QCRIVYLQYPSLIPHHQ-CSQLCL----------Y 379

  Fly   335 DYITNEGSKIFFRTNKNAPNYQVIAIDFNNSAEDKWETLIAEHKSDVLDWVKCVDNDKLLV--CY 397
            |:.|...|               :.:|           ::.....:....:.|    .||.  |:
Human   380 DWYTKVTS---------------VVVD-----------VVPRQLGENFSGIYC----SLLPLGCW 414

  Fly   398 IRDVKSVLQVNSLKDGTLLREFDLDIGTIV-----GTSGEKKYSEIFYNF--SSFLNPG------ 449
            ..|.:.|:..::.:....|...|..:||:.     |:.|..|...|..:.  :.|..|.
Human   415 SADSQRVVFDSAQRSRQDLFAVDTQVGTVTSLTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLK 479

  Fly   450 -----------SIYRYDFKTPDKSPSVFREIKLNLEGFRRED--YA---VEQIFYK---SKDGTK 495
                       |:.....:..:..|.:...|::......:|:  ||   .|.|..:   ..|.|:
Human   480 VGFLPSAGKEQSVLWVSLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQ 544

  Fly   496 VPMFIIRKKRDSVEPRPCL--LYGYGGFNISML------PSFGLSGLMF---IDTFDGVLAYPNL 549
            |||.::...|........|  |:..|.|.:..|      .||..:.::|   :......:...|.
Human   545 VPMVVMPHGRHLALRALALPALFLAGPFTLRSLSAGGPHSSFVTAWMLFPAMLCKMGFAVLLVNY 609

  Fly   550 RGGGEYGEKWHNGGRLLN------KQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVGSC 608
            ||...:|:     ..:|:      .|:| .|.|.|.|.:::.::.....:|:.|||:||.:....
Human   610 RGSTGFGQ-----DSILSLPGNVGHQDV-KDVQFAVEQVLQEEHFDASHVALMGGSHGGFISCHL 668

  Fly   609 INQRPDLFGAAVAQVGVMDMLRFHKFTIGHAWC-SDYGNPSEKEHFDNLYKF------SPLH--- 663
            |.|.|:.:.|.||:..|:::......|....|| .:.|.|...:...:|..:      ||:.
Human   669 IGQYPETYRACVARNPVINIASMLGSTDIPDWCVVEAGFPFSSDCLPDLSVWAEMLDKSPIRYIP 733

  Fly   664 NVHTPKGAETEYPSTLILTADHDDRVSPLHSLKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAG 728
            .|.||         .|::....|.||.....:::..||:.       :..||.|.:|.|:.|...
Human   734 QVKTP---------LLLMLGQEDRRVPFKQGMEYYRALKT-------RNVPVRLLLYPKSTHALS 782

  Fly   729 KPTSKRIEEATDILTFLSKSL 749
            :     :|..:|  :|::..|
Human   783 E-----VEVESD--SFMNAVL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	91/470 (19%)
		Aes	442..750	CDD:223730	75/362 (21%)
		Peptidase_S9	541..752	CDD:278741	51/225 (23%)
APEH	XP_024309267.1	EBV-NA3	<24..>128	CDD:332796	3/12 (25%)
APEH	XP_024309267.1	DAP2	202..804	CDD:224423	140/695 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4346
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030