DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5355 and SPBC1711.12

DIOPT Version :9

Sequence 1:	NP_609397.2	Gene:	CG5355 / 34421	FlyBaseID:	FBgn0032242	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_595885.1	Gene:	SPBC1711.12 / 2539662	PomBaseID:	SPBC1711.12	Length:	683	Species:	Schizosaccharomyces pombe

Alignment Length:	700	Identity:	126/700 - (18%)
Similarity:	231/700 - (33%)	Gaps:	218/700 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 NTLSEDGTIALTQKAFSEDGKYMA--YGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWT 225
            |.|...|....:..:|: |.||.:  |.|:||..:..::|:.    ||         ....::|.
pombe    41 NPLGNLGIFIESNYSFA-DHKYNSGIYLLNESTRNHQELLVH----GK---------SNKALTWI 91

  Fly   226 KDNKGFFYGRYPDQDGKTDGS----ETKQNENQKLYYH-------RVGESQDK--------DTLV 271
            .|: .|.|.|   :|..:..|    :......:.:|.|       |:||..:.        |..:
pombe    92 TDS-AFLYAR---EDNSSSSSILLFDVNNRSERIIYNHNSSISDIRIGEKNNHYRIVFSSVDNSL 152

  Fly   272 VEFPEE---------PSWRIQSTVSDCGKYLILAIVKDCRDNIVFYADLTPGAEITSKLNVKKIV 327
            |:.|..         ..|...:|.|....|.| .:.|...::..|........::..:..::..|
pombe   153 VKGPSNVHVYDHLFVRHWDRWNTGSRNTLYFI-ELDKKTENSNYFEISSEKAIDLLKETGLESPV 216

  Fly   328 EKFEADYDYITNEGSKIF-----------------FRTNKNAPNYQV------------IAIDFN 363
            |.|....|:.:|....:|                 :..|.|..|.:.            :|.|.|
pombe   217 EPFGGLSDFDSNYDKLVFVAKDPKLNPATQTKTVVYEINLNTRNLKSLSTAKGACSSPRLAKDGN 281

  Fly   364 NSAEDKW-ETLIAEHKSDVLDWVKCVDNDKLLVCYIRDVKSVLQVNSLKDGT---LLREFDLDIG 424
            :.|   | |....:::||                     ::.:.|...:.|.   :.|.:|....
pombe   282 HIA---WLEMQTPQYESD---------------------QNQIMVYESESGAKKHIARHWDRSPS 322

  Fly   425 TI---VGTSGE---------------------------------------KKYSEIFYNFSSFLN 447
            :|   |...||                                       .|.|.::...||.:|
pombe   323 SIEWGVFKGGEPGLFAIAENYGKQILFFVSIFHHQVIPMTEEHSVSSISVPKSSSLWLTKSSLIN 387

  Fly   448 PGSIYRYDFKTPDKSPSVFREIKLNLEGFRREDYAVEQIFYKSKDGTKVPMFIIRKKR-DSVEPR 511
            |....:.:.:|.::|..:...:.|:...:       |:|::....|.::..:|::.:. |..:..
pombe   388 PPYYAKINVETLNESVLLENNVGLSPTSY-------EEIWFPGTHGHRIHAWIVKPESFDKSKKY 445

  Fly   512 PCLLYGYGGFNISMLPSFGLSGLMFIDTFDGVLAYP-NLRGGGEYGEKWHN------GGRLLNKQ 569
            |..:..:||...|...|:.......:....|.:.:. :..|...||:::.:      ||:
pombe   446 PVAVLIHGGPQGSWTDSWSTRWNPAVFANAGFIVFALDPTGSTGYGQRFTDSIALDWGGK----- 505

  Fly   570 NVFDDFQAAAEYLIEN--KYTTKDRLAIQGGSNGGLLVGSCINQRP--DLFGAAVAQVGVMDMLR 630
             .:.|.:...|| |:|  .|...:::...|.|.||.:: :.|...|  ..|.|.|...||.:.|.
pombe   506 -PYKDIELGVEY-IKNHLSYADSEKMVALGASYGGYMI-NWIQGHPLGRQFRALVCHDGVFNTLN 567

  Fly   631 -----------FHKFTIGHAW----CSDYGNPSEKEHFDNLYKFSPLHNVHTPKGAETEYPSTLI 680
                       .|.|. |..|    ..:..|||   :|.|.:.        ||:         |:
pombe   568 TFYNTEELYFSIHDFG-GTPWENRVIYERWNPS---NFVNYWA--------TPE---------LV 611

  Fly   681 LTADHDDRVSPLHSLKFIAALQEAVRDSEFQKNPVLLRVYQKAGHGAGKP 730
            :.:..|.|::....:.....||       ::..|..|.|::...|...||
pombe   612 IHSSKDYRLTESEGIAAFNVLQ-------YKGIPSRLLVFEDENHWVIKP 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	69/408 (17%)
		Aes	442..750	CDD:223730	62/315 (20%)
		Peptidase_S9	541..752	CDD:278741	45/215 (21%)
SPBC1711.12	NP_595885.1	DAP2	21..675	CDD:224423	125/699 (18%)
SPBC1711.12	NP_595885.1	Peptidase_S9	463..675	CDD:278741	45/227 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4346
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030