Protein Alignment CG5355 and FAP

DIOPT Version :9

• Sequence 1: NP_609397.2
• Gene: CG5355 / 34421
• FlyBaseID: FBgn0032242
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_004451.2
• Gene: FAP / 2191
• HGNCID: 3590
• Length: 760
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 164/797 - (20%)
• Similarity: 279/797 - (35%)
• Gaps: 269/797 - (33%)

  Fly    80 STETEEFVNAQN---SISRPFLENGEEWKKLNTKLTKLWNYPKYGCPMRYGNYYYYFMNTG---- 137
            |..|.:.|||.|   |..|.|:       .|.:..:|||.| .|     ...||.|.::.|
Human    91 SNRTMKSVNASNYGLSPDRQFV-------YLESDYSKLWRY-SY-----TATYYIYDLSNGEFVR 142

  Fly   138 -------LQ--------------NQSVMYQQKSLGDESESKVFLDPNTLSEDGTIALTQKAFSED 181
                   :|              .|:.:|.::..||        .|..::.:|.   ..|.|:
Human   143 GNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGD--------PPFQITFNGR---ENKIFN-- 194

  Fly   182 GKYMAYGLSESGSDWIKILIRDAETGKDLSEVLEKVKFSEISWTKDNKGFFYGRYPDQDGKTDGS 246
                  |:    .||:            ..|.:...|:: :.|:.:.|...|..:.|.|...
Human   195 ------GI----PDWV------------YEEEMLATKYA-LWWSPNGKFLAYAEFNDTDIPV--- 233

  Fly   247 ETKQNENQKLYYHRVGESQDKDTLVVEFP----EEPSWRIQSTVSDCGKYLILAIVKDCRDNIVF 307
                     :.|...|:.|...|:.:.:|    :.|..||                        |
Human   234 ---------IAYSYYGDEQYPRTINIPYPKAGAKNPVVRI------------------------F 265

  Fly   308 YADLTPGAEI-TSKLNVKKIVEKFEADY-----DYITNEGSKIFFRTNKNAPNYQVIAI-DFNNS 365
            ..|.|..|.: ..::.|..::.  .:||     .::|:|  ::..:..|...|..|::| ||.
Human   266 IIDTTYPAYVGPQEVPVPAMIA--SSDYYFSWLTWVTDE--RVCLQWLKRVQNVSVLSICDFR-- 324

  Fly   366 AEDKWETL--------IAEHKS---------------DVLDWVKCVDNDK---LLVCYIRD-VKS 403
             || |:|.        |.|.::               |.:.:.| :.:||   ..:.||:| |::
Human   325 -ED-WQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYK-IFSDKDGYKHIHYIKDTVEN 386

  Fly   404 VLQVNSLKDGTLLREFDLDIGTIVGTSGEKKYSEIFYNFSSFLN-PG--SIYRYDFKT--PDK-- 461
            .:|:.|.|...      ::|..:...|       :||:.:.|.. ||  :|||....:  |.|
Human   387 AIQITSGKWEA------INIFRVTQDS-------LFYSSNEFEEYPGRRNIYRISIGSYPPSKKC 438

  Fly   462 -----------------------------SPSV----------FREIKLNLEGFRREDYAVEQIF 487
                                         .|.:          .:|||: ||..:..:.|::.|.
Human   439 VTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKI-LEENKELENALKNIQ 502

  Fly   488 YKSKDGTKVPM--------FIIRKKRDSVEPRPCLLYGYGG-FNISMLPSFGLSGLMFIDTFDG- 542
            ...::..|:.:        .|:..:.|..:..|.|:..||| .:.|:...|.::.:.::.:.:|
Human   503 LPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGM 567

  Fly   543 VLAYPNLRGGGEYGEK-WHNGGRLLNKQNVFDDFQAAAEYLIENKYTTKDRLAIQGGSNGGLLVG 606
            |:|..:.||....|:| .:...|.|....|.|...|..:: ||..:..:.|:||.|.|.||.:..
Human   568 VIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKF-IEMGFIDEKRIAIWGWSYGGYVSS 631

  Fly   607 SCINQRPDLF--GAAVAQVGVMDMLRFHKFTIGHAWCSDY-----GNPSEKEHFDNLYKFSPLHN 664
            ..:.....||  |.|||.|...:.           :.|.|     |.|::.::.:: ||.|.:.
Human   632 LALASGTGLFKCGIAVAPVSSWEY-----------YASVYTERFMGLPTKDDNLEH-YKNSTVM- 683

  Fly   665 VHTPKGAETEY---PSTLILTADHDDRVSPLHSLKFIAALQEAVRDSEFQKNPVLLRVYQKAGHG 726
                  |..||   ...|::....||.|...:|.:...||..|..|  ||     ...|....||
Human   684 ------ARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVD--FQ-----AMWYSDQNHG 735

  Fly   727 -AGKPTSKRIEEATDIL 742
             :|..|:......|..|
Human   736 LSGLSTNHLYTHMTHFL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5355	NP_609397.2	Peptidase_S9_N	51..467	CDD:280970	91/498 (18%)
		Aes	442..750	CDD:223730	82/369 (22%)
		Peptidase_S9	541..752	CDD:278741	56/215 (26%)
FAP	NP_004451.2	DPPIV_N	106..472	CDD:366374	85/472 (18%)
		Peptidase_S9	553..756	CDD:366030	57/227 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000